2 results match your criteria: "Universityof California San Diego[Affiliation]"
The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma.
Mol Cancer Res
June 2011
Department of Pediatrics, Universityof California San Diego, La Jolla, CA 92093, USA.
Article Synopsis
- Pancreatic ductal adenocarcinoma (PDA) has a very low 5-year survival rate, and understanding cell-cycle control in the pancreas is key for improving treatment.
- The study found that the Id3 protein, which inhibits bHLH transcription factors, is significantly upregulated in diseased pancreatic cells, suggesting an imbalance between Id3 and bHLH proteins affects cell growth.
- By expressing Id3 in normal pancreatic duct cells, researchers observed that it triggered cell-cycle entry, highlighting the Id/bHLH axis as a promising target for therapeutic intervention in pancreatitis and PDA.
Actin polymerization: riding the wave.
Curr Biol
February 2004
Section of Cell and Developmental Biology, Universityof California San Diego, La Jolla, 92093, USA.
WAVE/SCAR has long been known to activate the actin-nucleating Arp2/3 complex in a Rac-dependent manner. Recent biochemical and genetic studies have revealed important roles for four WAVE-associated proteins in regulating WAVE function.
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