A large-scale retrospective study in China explores risk factors for disease severity in plaque psoriasis.

Severe psoriasis has a long course and poor outcome, and it has long been a problem for patients. Understanding the independent risk factors that contribute to patients with severe psoriasis is critical for the development of effective treatment strategies. This large, multicenter study recruited 2,109 plaque psoriasis patients from 12 hospitals across China (October 31, 2019 - May 31, 2022).

Environmental contamination and risks of organic UV filters: Source, discharge, analytical methods and implications for ecological and human health.

Organic Ultraviolet Filters (OUVFs), commonly used in sunscreens, cosmetics and industrial products to prevent ultraviolet radiation damage, are increasingly detected in the environment due to their widespread use and persistence. This has raised concerns over their toxicity and environmental impact, leading to the classification of OUVF 2-(2H-Benzotriazol-2-yl)-4,6-ditertpentylphenol (UV-328) as a persistent organic pollutant under the Stockholm Convention in 2023. In this review, current knowledge on the usage, discharge and environmental contamination of OUVFs is briefly discussed.

A novel colorimetric and fluorometric dual-signal identification of crude baijiu based on La-CDs.

The correct classification of strong-flavored crude baijiu affects its quality and overall standard and is crucial for the intelligent development of the baijiu industry. In this work, we developed a novel optical sensing array using lanthanum-doped carbon dots (La-CDs). Using La-CDs with three metal complex dyes-chromium black T, alizarin red, and dimethylphenol orange-we were able to detect organic acids and tannic acid (TA) in crude baijiu in a way that was both colorimetric and fluorescent for the first time.

GLE-net: global-local information enhancement for semantic segmentation of remote sensing images.

Remote sensing (RS) images contain a wealth of information with expansive potential for applications in image segmentation. However, Convolutional Neural Networks (CNN) face challenges in fully harnessing the global contextual information. Leveraging the formidable capabilities of global information modeling with Swin-Transformer, a novel RS images segmentation model with CNN (GLE-Net) was introduced.

Depicting Primate-Like Granular Dorsolateral Prefrontal Cortex in the Chinese Tree Shrew.

It remains unknown whether the Chinese tree shrew, regarded as the closest sister of primate, has evolved a dorsolateral prefrontal cortex (dlPFC) comparable with primates that is characterized by a fourth layer (L4) enriched with granular cells and reciprocal connections with the mediodorsal nucleus (MD). Here, we reported that following AAV-hSyn-EGFP expression in the MD neurons, the fluorescence micro-optical sectioning tomography revealed their projection trajectories and targeted brain areas, such as the hippocampus, the corpus striatum, and the dlPFC. Cre-dependent transsynaptic viral tracing identified the MD projection terminals that targeted the L4 of the dlPFC, in which the presence of granular cells was confirmed via cytoarchitectural studies by using the Nissl, Golgi, and vGlut2 stainings.

Dynamic meta-graph convolutional recurrent network for heterogeneous spatiotemporal graph forecasting.

Spatiotemporal Graph (STG) forecasting is an essential task within the realm of spatiotemporal data mining and urban computing. Over the past few years, Spatiotemporal Graph Neural Networks (STGNNs) have gained significant attention as promising solutions for STG forecasting. However, existing methods often overlook two issues: the dynamic spatial dependencies of urban networks and the heterogeneity of urban spatiotemporal data.

On the Exploration of Quantum Polar Stabilizer Codes and Quantum Stabilizer Codes with High Coding Rate.

Inspired by classical polar codes, whose coding rate can asymptotically achieve the Shannon capacity, researchers are trying to find their analogs in the quantum information field, which are called quantum polar codes. However, no one has designed a quantum polar coding scheme that applies to quantum computing yet. There are two intuitions in previous research.

Autonomous Robot Task Execution in Flexible Manufacturing: Integrating PDDL and Behavior Trees in ARIAC 2023.

The Agile Robotics for Industrial Automation Competition (ARIAC) was established to advance flexible manufacturing, aiming to increase the agility of robotic assembly systems in unstructured and dynamic industrial environments. ARIAC 2023 introduced eight agility challenges involving faulty parts, flipped parts, faulty grippers, robot malfunctions, sensor blackouts, high-priority orders, insufficient parts, and human safety. Given the unpredictability of these scenarios, it is impractical to develop a specific strategy for each possible situation.

CircTIAM1 overexpression promotes the progression of papillary thyroid cancer by regulating the miR-338-3p/LASP1 axis.

Background: Papillary thyroid cancer (PTC) is the most prevalent histological type of differentiated thyroid malignancy. Circular RNAs (circRNAs) have been implicated in the pathogenesis and progression of various cancers. circTIAM1 (hsa_circ_0061406) is a novel circRNA with aberrant expression in PTC.

Nuciferine Alleviates High-Fat Diet- and ApoE-Induced Hepatic Steatosis and Ferroptosis in NAFLD Mice via the PPARα Signaling Pathway.

Nonalcoholic fatty liver disease (NAFLD) causes significant global mortality and healthcare costs with no recommended pharmacological intervention for clinical management. Nuciferine (Nuc) is an alkaloid with aromatic rings, abundantly found in . In this study, we explored the protective mechanisms of Nuc against hepatic steatosis and ferroptosis in NAFLD.

 (Araceae, Potheae, Pothoideae), a new species from Bukidnon, Mindanao, Philippines.

A new species of is described and illustrated. This species is very similar to (sheathing and leaf morphology) but differs by the inflorescence and flowers. It is closely related also to by the deep purple inflorescence, but differs in having longer peduncle, broadly ovate-concave to cucullate spathe (which is deep wine-red when fresh to purplish-black when senescing), and the spadix that is 7/10 the entire length of the spathe.

Long-Term Survival Outcomes in Locally Advanced Breast Cancer after Mastectomy with or without Breast Reconstruction.

Introduction: There is ongoing debate about the safety of breast reconstruction for patients with locally advanced breast cancer (LABC) who have undergone total mastectomy (TM). More and more LABC patients are undergoing breast reconstruction after TM, but its long-term survival outcomes remain unclear. This study aimed to compare the survival outcomes of LABC patients who underwent breast reconstruction after TM with those who did not, based on a large sample.

Uric acid-to-high-density lipoprotein cholesterol ratio and osteoporosis: Evidence from the national health and nutrition examination survey.

The uric acid-to-high-density lipoprotein cholesterol ratio (UHR) has emerged as a novel indicator of inflammatory and metabolic status. This study aims to examine the association between UHR and bone mineral density (BMD), as well as the risk of osteoporosis, in individuals aged ≥50 years. This cross-sectional study used data from the National Health and Nutrition Examination Survey, focusing on participants aged ≥50 years.

Splitting and separation mechanism of tenofovir alafenamide fumarate chiral isomers based on indirect chiral ligand exchange chromatography.

The isolation and analysis of chiral isomers are critical parts of the drug development process to ensure effective and safe drug administration to patients. Indirect chiral ligand exchange chromatography (ICLEC) was developed to separate and determine tenofovir alafenamide fumarate (TAF) and its diastereoisomer GS-7339, with a hypothesized separation mechanism. The effect of using a chiral column a standard C18 column on the separation of the TAF chiral isomer mixture was investigated.

Study on porous coral scaffolds containing a hydroxyapatite layer doped with selenium and their properties.

The repair of bone defects caused by osteosarcoma is still a significant clinical issue, and new scaffolds need to be developed to solve this problem. The ocean is a treasure trove for developing new biomedical materials, and coral is widely thought to be suitable as a scaffold for bone implant materials due to its porous structure and mechanical properties. Selenium is known for its antioxidant and antitumor effects, inducing tumor cell cycle arrest.

Corticosteroids for hospitalized patients with severe/critical COVID-19: a retrospective study in Chongqing, China.

Corticosteroids have always been recommended for severe cases of COVID-19. However, the efficacy of treatment with corticosteroids for COVID-19 during the SARS-CoV-2 omicron outbreak in China has not been reported. Clinical data from 406 patients hospitalized for severe/critical COVID-19 from December 2022 to January 2023 at six hospitals in Chongqing were retrospectively analyzed.

Evaluating pulmonary toxicity of PFOS and its alternative OBS using spheroids of A549 cells.

Sodium p-perfluorous nonenoxybenzene sulfonate (OBS) is a prominent alternative to perfluorooctanesulfonic acid (PFOS). Numerous studies have demonstrated hepatotoxicity and neurotoxicity of OBS and PFOS in mammals. The lungs, as a sensitive organ, are among the potential target organs for OBS and PFOS exposure.