PRAF2 as a novel biomarker for breast cancer with machine learning and experimentation validation.

Background: Breast cancer (BC) is the most prevalent malignancy in women. Potential therapeutic targets for BC are of great significance. In our previous study, we found that prenylated rab acceptor 1 domain family member 2 (PRAF2) is an oncogene in BC.

Enhanced Ocular Bioavailability and Prolonged Duration via Hydrophilic Surface Nanocomposite Vesicles for Topical Drug Administration.

Background: Internal ocular diseases, such as macular edema, uveitis, and diabetic macular edema require precise delivery of therapeutic agents to specific regions within the eye. However, the eye's complex anatomical structure and physiological barriers present significant challenges to drug penetration and distribution. Traditional eye drops suffer from low bioavailability primarily due to rapid clearance mechanisms.

Effect of Music Intervention on Improving the Early Prognosis of the Preterm Infant in Chongqing, China: A Randomized Controlled Trial.

Objectives: To investigate the effects of music intervention on the vital signs, weight gain, feeding, hospital stays, and cost of premature infants.

Methods: 100 premature infants were randomized into two groups: the experimental group (given music for 30 min at a time, once every day until discharge) and the control group (without music). To compare the vital signs (RR, HR, SPO) before, during, and after the music intervention, as well as the weight gain and feeding, follow up to 3 months after discharge.

Integrating network pharmacology to investigate the mechanism of quercetin's action through AKT inhibition in co-expressed genes associated with polycystic ovary syndrome and endometrial cancer.

Endometrial cancer (EC) is a common gynecological malignancy for which polycystic ovarian syndrome (PCOS) has been identified as a significant risk factor. Quercetin, a widely distributed natural flavonoid, has demonstrated potential therapeutic effects in managing both PCOS and EC. However, the specific molecular targets of quercetin in the context of PCOS comorbid with EC (PCOS-EC) remain poorly defined.

Electrolyte Decoupling Strategy for Metal Oxide-Based Zinc-ion Batteries Free of Crosstalk Effect.

The crosstalk of transition metal ions between the metal oxide cathode and Zn anode restricts the practical applications of aqueous zinc-ion batteries (ZIBs). Herein, we propose a decoupled electrolyte (DCE) consisting of a nonaqueous-phase (N-phase) anolyte and an aqueous-phase (A-phase) catholyte to prevent the crosstalk of Mn2+, thus extending the lifespan of MnO2-based ZIBs. Experimental measurements and theoretical modelling verify that trimethyl phosphate (TMP) not only synergistically works with NH4Cl in the N-phase anolyte to enable fast Zn2+ conduction while block Mn2+ diffusion toward anode, but also modifies the Zn2+ solvation structure to suppress the dendrite formation and corrosion on Zn anode.

Unveiling airborne threats: Vertical profiles of multiple emerging pollutants in PM across the urban atmosphere of Southern China.

PM has a detrimental impact on human health and has become a focus of widespread concern. The tempo-spatial distribution of emerging pollutants has been extensively studied, while there is a scarcity of understanding their vertical distribution in atmospheric environment. Here we investigated the vertical profiles of phthalate esters (PAEs), organophosphate esters (OPEs), neonicotinoids (NEOs), and per-and polyfluorinated substances (PFASs) in PM at ground level (4.

Prevalence of metal implants among US adults aged 40 years and older.

Metal implants are commonly used in clinical practice. However, little is known regarding the prevalence of metal implants. Therefore, this study aimed to evaluate the prevalence of metal implants in the United States (US) among individuals aged ≥ 40 years.

Early Identification of Myocardial Microstructural Alterations in Hypertrophic Cardiomyopathy with in Vivo Cardiac Diffusion-Tensor Imaging.

Purpose To explore the diffusion characteristics of hypertrophic cardiomyopathy (HCM) using in vivo cardiac diffusion-tensor imaging (cDTI) and to determine whether cDTI could help identify abnormal myocardium beyond cardiac MRI findings of fibrosis and hypertrophy. Materials and Methods In this prospective study conducted from April to August 2023, participants with HCM and healthy volunteers were enrolled for cardiac MRI evaluation, including cine, late gadolinium enhancement (LGE), T1 mapping, and cDT imaging, using a 3.0-T scanner.

Antitussive drug dextromethorphan induces developmental impairment in zebrafish.

Dextromethorphan (DXM) is a common ingredient in cough and cold remedies. Despite its widespread presence in aquatic environments, the impact of DXM on fish remains largely unknown. This study evaluated the developmental impairment of zebrafish embryos exposed to DXM from 2 hours post-fertilization (hpf) to 14 days post-fertilization (dpf) at five different exposure concentrations: 0.

Molecular epidemiological analysis of Influenza viruses in Influenza-like illness cases: a retrospective study in Chongqing Hi-Tech Zone, China (2021-2024).

Objectives: To analyze the molecular epidemiological characteristics of influenza viruses in influenza-like cases in Chongqing Hi-Tech Zone, China, to provide data support and a scientific basis for optimizing influenza prevention and control strategies in the region.

Materials And Methods: A retrospective analysis was conducted on the molecular epidemiological characteristics of influenza viruses in influenza-like cases at a hospital in Chongqing Hi-Tech Zone from 2021 to 2024. Colloidal gold detection of viral antibodies, fluorescent PCR detection of nucleic acids, and gene sequencing were used to identify the different subtypes.

Association of RFC G80A Polymorphism with Lung Cancer Susceptibility in a Hypertensive Population: A Nested Case-Control Study.

Background: Polymorphisms of the folate-associated one-carbon metabolism (OCM) pathway genes may regulate certain susceptibilities to cancer. G80A, a polymorphism in the reduced folate carrier (RFC) gene, may be associated with cancer risk, although the results obtained from previous studies have been inconsistent.

Objectives: The present study aimed to evaluate the association of G80A with lung cancer among a Chinese population, and to examine the potential effect modifiers.

Association of platelet-to-lymphocyte ratio with 1-year all-cause mortality in ICU patients with heart failure.

The Platelet-to-Lymphocyte Ratio (PLR) has emerged as a cost-effective biomarker for systemic inflammation and adverse cardiovascular outcomes, yet its prognostic value in critically ill patients with heart failure (HF) remains unclear. Leveraging the MIMIC-IV database, this study investigates the association between PLR and 1-year all-cause mortality in 7,217 ICU patients with HF. Patients were stratified into tertiles (0-126.

The specific medications for pulmonary arterial hypertension at functional class III to IV: a systematic review and meta-analysis.

Purpose: To systematically evaluate the clinical efficacy and safety of targeted drugs in patients with pulmonary arterial hypertension (PAH) with cardiac function grades III-IV, and conduct a meta-analysis.

Methods: Two researchers independently searched the PubMed, EMBASE, and Cochrane Library databases for relevant studies, with the search period extending from the establishment of the databases to March 2024. Meta-analysis was performed using statistical software Review Manager 5.

Sappanone A alleviates metabolic dysfunction-associated steatohepatitis by decreasing hepatocyte lipotoxicity via targeting Mup3 in mice.

Background And Purpose: Metabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory lipotoxic disorder marked by hepatic steatosis, hepatocyte damage, inflammation, and varying stages of fibrosis. Sappanone A (SA), a flavonoid, exhibits anti-inflammatory and hepatoprotection activities. Nevertheless, the effects of SA on MASH remain ambiguous.

Impact of physicochemical and microbial drivers on the formation of disinfection by-products in drinking water distribution systems: A multivariate Bayesian network modeling approach.

The formation of disinfection byproducts (DBPs) in drinking water distribution systems (DWDS) is significantly affected by numerous factors, including physicochemical water properties, microbial community composition and structure, and the characteristics of organic DBP precursors. However, the codependence of various factors remains unclear, particularly the contribution of microbial-derived organics to DBP formation, which has been inadequately explored. Herein, we present a Bayesian network modeling framework incorporating a Bayesian-based microbial source tracking method and excitation-emission fluorescence spectroscopy-parallel factor analysis to capture the critical drivers influencing DBP formation and explore their interactions.

Discovery of novel xanthohumol C derivatives regulating XRCC2 transcription and expression for the treatment of colorectal cancer.

X-ray repair cross-complementing 2 (XRCC2), a critical protein in homologous recombination (HR), plays a significant role in the occurrence, progression, and drug resistance of colorectal cancer (CRC). In this study, a series of xanthohumol C derivatives were synthesized, and their anticancer activity was evaluated. The results revealed that A33 demonstrated the potent anticancer activity and effectively inhibited the proliferation of CRC cells in vitro.

Co-metabolism of Norfloxacin by Chlorella pyrenoidosa: Carbon source effects, biotransformation mechanisms, and key driving genes.

Co-metabolism with appropriate carbon sources has been demonstrated to effectively enhance the removal of ubiquitous recalcitrant micropollutant by microalgae. However, the specific impacts of carbon sources on the co-metabolism of antibiotics by microalgae remain insufficiently explored. In this study, transcriptomics, gene network analysis, extracellular polymeric substances (EPS), and enzymatic activity involved in co-metabolic pathways of norfloxacin (NFX), were systematically evaluated to investigate the underlying biological mechanisms involved in NFX co-metabolism by Chlorella pyrenoidosa.

Contaminant-degrading bacteria are super carriers of antibiotic resistance genes in municipal landfills: A metagenomics-based study.

Municipal landfills are hotspot sources of antimicrobial resistance (AMR) and are also important habitats of contaminant-degrading bacteria. However, high diversity of antibiotic resistance genes (ARGs) in landfills hinders assessing AMR risks in the affected environment. More concerned, whether there is co-selection or enrichment of antibiotic-resistant bacteria and contaminant-degrading bacteria in these extremely polluted environments is far less understood.

Wearable Fabric System for Sarcopenia Detection.

Sarcopenia has been a serious concern in the context of an increasingly aging global population. Existing detection methods for sarcopenia are severely constrained by cumbersome devices, the necessity for specialized personnel, and controlled experimental environments. In this study, we developed an innovative wearable fabric system based on conductive fabric and flexible sensor array.

An MSRE-Assisted Glycerol-Enhanced RPA-CRISPR/Cas12a Method for Methylation Detection.

Background: Nasopharyngeal carcinoma (NPC) is a malignant tumor with high prevalence in southern China. Aberrant DNA methylation, as a hallmark of cancer, is extensively present in NPC, the detection of which facilitates early diagnosis and prognostic improvement of NPC. Conventional methylation detection methods relying on bisulfite conversion have limitations such as time-consuming, complex processes and sample degradation; thus, a more rapid and efficient method is needed.

Relationship between cyberbullying victimization and depression in middle school students: the mediating role of coping strategies and the moderating role of face consciousness.

Background: The more rapid adoption of the Internet in education settings has raised concerns about its impact on adolescents who may suffer from cyberbullying victimization. As a negative life experience, cyberbullying victimization can adversely affect adolescents' mental health. Particularly, it can lead to more adolescents developing depression.

Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for hyperemesis gravidarum.

Background: Hyperemesis gravidarum (HG), excessive vomiting in pregnancy, occurs in 0.3-10.8% of pregnancies and is associated with maternal and fetal morbidity.

Association between ambient temperatures and cardiovascular disease: A time series analysis using emergency ambulance dispatches in Chongqing, China, 2019-2021.

Background: Cardiovascular disease (CVD) is one of the leading causes of death globally. Yet, further research is required into the relationship between CVD and extreme environmental temperatures. This study aims to explore the association between the incidence of CVD and extreme temperatures, and also to identify susceptible subgroups within the population.