Comparing patellofemoral kinematics assessed with a novel Muscle Actuator System and an Oxford Rig using non-cadaveric knees.

Total knee replacement (TKR) failure, low patient satisfaction and high revision surgery rates may stem from insufficient pre-clinical testing. Conventional joint motion simulators for pre-clinical testing of TKR implants manipulate a knee joint in force, displacement, or simulated muscle control. However, a rig capable of using all three control modes has yet to be described in literature.

Non-lytic spread of poliovirus requires the nonstructural protein 3CD.

Unlabelled: Non-enveloped viruses like poliovirus (PV) have evolved the capacity to spread by non-lytic mechanisms. For PV, this mechanism exploits the host secretory autophagy pathway. Virions are selectively incorporated into autophagosomes, double-membrane vesicles that travel to the plasma membrane, fuse, and release single-membrane vesicles containing virions.

Positive well-being and dampened emotional reactivity to daily family conflict and family cohesion.

Conflict and a lack of cohesive daily family relationships can negatively affect adolescent adjustment, although adolescents differ in how they respond (i.e., their emotional reactivity) to these daily experiences.

Unravelling Orthopaedic Surgeons' Perceptions and Adoption of Generative AI Technologies.

This mixed-methods study investigates the adoption of generative AI among orthopaedic surgeons, employing a Unified Theory of Acceptance and Use of Technology (UTAUT) based survey ( = 177) and follow-up interviews ( = 7). The research reveals varying levels of AI familiarity and usage patterns, with higher adoption in research and professional development compared to direct patient care. A significant generational divide in perceived ease of use highlights the need for tailored training approaches.

Strong electron-phonon coupling in magic-angle twisted bilayer graphene.

The unusual properties of superconductivity in magic-angle twisted bilayer graphene (MATBG) have sparked considerable research interest. However, despite the dedication of intensive experimental efforts and the proposal of several possible pairing mechanisms, the origin of its superconductivity remains elusive. Here, by utilizing angle-resolved photoemission spectroscopy with micrometre spatial resolution, we reveal flat-band replicas in superconducting MATBG, where MATBG is unaligned with its hexagonal boron nitride substrate.

CHiTA: A scarless high-throughput pipeline for characterization of ribozymes.

Small self-cleaving ribozymes are catalytic RNAs that cleave their phosphodiester backbone rapidly and site-specifically, without the assistance of proteins. Their catalytic properties make them ideal targets for applications in RNA pharmaceuticals and bioengineering. Consequently, computational pipelines that predict or design thousands of self-cleaving ribozyme candidates have been developed.

Selenoproteome depletion enhances oxidative stress and alters neutrophil functions in Citrobacter rodentium infection leading to gastrointestinal inflammation.

Reactive oxygen species (ROS) play a critical role in modulating a range of proinflammatory functions in neutrophils, as well as regulating neutrophil apoptosis and facilitating the resolution of an inflammatory response. Selenoproteins with the 21st amino acid, selenocysteine (Sec), regulate immune mechanisms through the modulation of redox homeostasis aiding in the efficient resolution of inflammation, while their role in neutrophil functions during diseases remains unclear. To study the role of selenoproteins in neutrophils during infection, we challenged the granulocyte-specific tRNA (Trsp) knockout mice (Trsp) with Citrobacter rodentium (C.

Daily reciprocal relationships between affect, physical activity, and sleep in middle and later life.

Background: The daily dynamics among affect, physical activity, and sleep are often explored by taking a unidirectional approach. Yet, obtaining a comprehensive understanding of the reciprocal dynamics among affect and health behaviors is crucial for promoting daily well-being.

Purpose: This study examined the reciprocal associations among affect, physical activity, and sleep in daily life in a U.

Age is associated with altered locomotor and hypothermic response to acute nicotine.

Cigarette smoking is at an all-time low. However, nicotine consumption has diversified with the introduction of commercial tobacco products that include Electronic Nicotine Delivery Systems. Nicotine is the main psychoactive component of tobacco and contributes to the addictive properties of tobacco products.

TRICHINELLA INFECTIONS IN WILDLIFE FROM PENNSYLVANIA: VARIATION IN EXPOSURE AMONG COYOTE (CANIS LATRANS), GRAY FOX (UROCYON CINEREOARGENTEUS), AND RED FOX (VULPES VULPES).

During a survey for Sarcocystis infections in Pennsylvania in wild canids, muscles from the tongue and limb were examined microscopically for sarcocysts. Between 9 February 2024 and 11 February 2024, muscle samples were collected from 76 coyotes, 46 gray foxes, and 21 red foxes from Pennsylvania hunter harvested animals. Around 5 g of muscle was examined microscopically by compression between a glass slide and coverslip.

More Positive Attitudes to Aging are Associated with Lower Subjective Cognitive Decline: Moderating Roles of Affective Well-Being.

This study cross-sectionally examined associations between older adults' aging attitudes and subjective cognitive decline as well as moderating effects of current positive affect and depressive symptoms. Data were collected via an online survey among U.S.

Iterative One-Carbon Homologation of Unmodified Carboxylic Acids.

The one-carbon homologation of carboxylic acids is a valuable route to construct families of homologues, which play fundamental roles in chemistry and biology. However, known procedures are based on multistep sequences, use harsh conditions or are limited in scope. Thus, almost a century after the discovery of the original Arndt-Eistert homologation sequence, a general method to directly convert carboxylic acids into their corresponding homologues remains elusive.

With a little help from my friends: Social support, hope and climate change engagement.

Hope is a future-oriented emotion that attunes people to the possibility of positive change, and thus could potentially catalyse societal engagement with climate change. A recent meta-analysis suggests that the relationship between hope and climate action is most robust when the target of hope is climate engagement (i.e.

Recently Delisted Songbird Harbors Extensive Genomic Evidence of Inbreeding, Potentially Complicating Future Recovery.

The Kirtland's warbler () is a rare migratory passerine species and habitat specialist of the North American Jack Pine Forests. Their near extinction in the 1970s classified them as endangered and protected under the Endangered Species Act of 1973. After decades of intense conservation management, their population size recovered, and they were delisted from federal protection in 2019.

Aspergillus ullungdoensis sp. nov., Penicillium jeongsukae sp. nov., and other fungi from Korea.

Eurotiales fungi are thought to be distributed worldwide but there is a paucity of information about their occurrence on diverse substrates or hosts and at specific localities. Some of the Eurotiales, including Aspergillus and Penicillium species, produce an array of secondary metabolites of use for agricultural, medicinal, and pharmaceutical applications. Here, we carried out a survey of the Eurotiales in South Korea, focusing on soil, freshwater, and plants (dried persimmon fruits and seeds of Perilla frutescens, known commonly as shiso).

Nanoparticles with "" Metals Bring "Color" in Multiscale Spectral Photon Counting X-ray Imaging.

Preclinical and clinical diagnostics depend greatly on medical imaging, which enables the identification of physiological and pathological processes in living subjects. It is often necessary to use contrast agents to complement anatomical data with functional information or to describe the disease phenotypically. Nanomaterials are used as contrast agents in many advanced bioimaging techniques and applications because of their high payload, physicochemical properties, improved sensitivity, and multimodality.

Pesticide use in integrated pest and pollinator management framework to protect pollinator health.

Agricultural pesticides have historically been a critical tool in controlling pests and diseases, preventing widespread suffering and crop losses that led to catastrophes such as the Great Irish Famine (1845-1852) and the Cotton Boll Weevil Infestation (1915-1916). However, their usage has brought challenges, including resistance development, secondary pest outbreaks, harm to non-target organisms like pollinators, and environmental contamination. In response to these concerns, integrated pest management (IPM) has emerged as a comprehensive approach, emphasizing non-chemical pest control methods such as cultural practices, biological control, and crop rotation, with pesticides as the last resort.

Nonlinear memristor model with exact solution allows for reservoir computing training and inference.

Memristive physical reservoir computing is a promising approach for solving data classification and temporal processing tasks. This method exploits the nonlinear dynamics of physical, low-power devices to achieve high-dimensional mapping of input signals. Ion-channel-based memristors, which operate with similar voltages, currents, and timescales as biological synapses, are promising due to their rich dynamics, especially for use in biological edge settings.

The power of lived experience in optimizing US policymakers' engagement with substance use research: A series of rapid-cycle randomized controlled trials.

Background: Research can inform policies on substance use/substance use disorders (SU/SUDs), yet there is limited experimental investigation into strategies for optimizing policymakers' engagement with SU/SUD research. This study tested the use of narratives to boost policymakers' research engagement.

Methods: In five rapid-cycle randomized controlled trials, SU/SUD research fact sheets were emailed to US legislative policymakers.