Stability analysis in COVID-19 within-host model with immune response.

The 2019 coronavirus disease (COVID-19) is now a global pandemic. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative pathogen of COVID-19. Here, we study an in-host model that highlights the effector T cell response to SARS-CoV-2.

Disaster preparedness of local governments in Panay Island, Philippines.

Disaster preparedness plans reduce future damages, but may lack testing to assess their effectiveness in operation. This study used the state-designed Local Government Unit Disaster Preparedness Journal: Checklist of Minimum Actions for Mayors in assessing the readiness to natural hazards of 92 profiled municipalities in central Philippines inhabited by 2.4 million people.

Comparative Genomic and Transcriptomic Analyses Revealed Twenty-Six Candidate Genes Involved in the Air-Breathing Development and Function of the Bighead Catfish Clarias macrocephalus.

The bighead catfish (Clarias macrocephalus) and channel catfish (Ictalurus punctatus) are freshwater species in the Siluriformes order. C. macrocephalus has both gills and modified gill structures serving as an air-breathing organ (ABO), while I.

Geochemical speciation of metals (Cu, Pb, Cd) in fishpond sediments in Batan Bay, Aklan, Philippines.

Batan Bay in Aklan, Philippines supports a population largely dependent on coastal fisheries. The development of aquaculture technologies coupled with over-crowded fish pens has negatively affected its natural dynamics and environmental quality. Land-use activities including ports and shipyard further aggravate the problem by contributing to chemical pollution.

Cathelicidins enhance protection of channel catfish, Ictalurus punctatus, and channel catfish ♀ × blue catfish, Ictalurus furcatus ♂ hybrid catfish against Edwarsiella ictaluri infection.

Cathelicidins are a class of antimicrobial peptides (AMPs) known to possess rapid and direct antimicrobial activities against a variety of microorganisms. Recently identified cathelicidins derived from alligator and sea snake were found to be more effective in inhibiting microbial growth than other AMPs previously characterized. The ability of these two cathelicidins along with the peptides, cecropin and pleurocidin, to protect channel catfish (Ictalurus punctatus, Rafinesque) and hybrid catfish (I.

Reusable Chemically-Micropatterned Substrates via Sequential Photoinitiated Thiol-Ene Reactions as Template for Perovskite Thin-Film Microarrays.

Patterning semiconducting materials are important for many applications such as microelectronics, displays, and photodetectors. Lead halide perovskites are an emerging class of semiconducting materials that can be patterned via solution-based methods. Here we report an all-benchtop patterning strategy by first generating a patterned surface with contrasting wettabilities to organic solvents that have been used in the perovskite precursor solution then spin-coating the solution onto the patterned surface.

aBravo Is a Novel Antiviral Protein that Interacts with, but Acts Independently of, the Exogenous siRNA Pathway Effector Dicer 2.

Mosquitoes, such as , can transmit arboviruses to humans. The exogenous short interfering RNA (exo-siRNA) pathway plays a major antiviral role in controlling virus infection in mosquito cells. The Dicer 2 (Dcr2) nuclease is a key effector protein in this pathway, which cleaves viral double-stranded RNA into virus-derived siRNAs that are further loaded onto an effector called Argonaute 2 (Ago2), which as part of the multiprotein RNA-induced silencing complex (RISC) targets and cleaves viral RNA.

Oncomelania hupensis quadrasi: Snail intermediate host of Schistosoma japonicum in the Philippines.

Oncomelania hupensis quadrasi is the snail intermediate host of Schistosoma japonicum in the Philippines. It was discovered by Dr. Marcos Tubangui in 1932 more than two decades after the discovery of the disease in the country in 1906.

Toward Sustainable Environmental Quality: Priority Research Questions for Asia.

Environmental and human health challenges are pronounced in Asia, an exceptionally diverse and complex region where influences of global megatrends are extensive and numerous stresses to environmental quality exist. Identifying priorities necessary to engage grand challenges can be facilitated through horizon scanning exercises, and to this end we identified and examined 23 priority research questions needed to advance toward more sustainable environmental quality in Asia, as part of the Global Horizon Scanning Project. Advances in environmental toxicology, environmental chemistry, biological monitoring, and risk-assessment methodologies are necessary to address the adverse impacts of environmental stressors on ecosystem services and biodiversity, with Asia being home to numerous biodiversity hotspots.

Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive Subtype/Presentation: Research Progress and Translational Studies.

Research on the predominantly inattentive attention-deficit/hyperactivity disorder (ADHD-PI) subtype/presentation is important given its high prevalence, but paradoxically it is under-recognized and undertreated. The temporal stability of the inattention symptom could impact the high worldwide prevalence of ADHD-PI. Some evidence suggests differences in the nature of attentional deficit in ADHD-PI vs.

Glucose-Regulated Protein 78 Interacts with Zika Virus Envelope Protein and Contributes to a Productive Infection.

Zika virus (ZIKV; Flaviviridae) is a mosquito-borne flavivirus shown to cause fetal abnormalities collectively known as congenital Zika syndrome and Guillain-Barré syndrome in recent outbreaks. Currently, there is no specific treatment or vaccine available, and more effort is needed to identify cellular factors in the viral life cycle. Here, we investigated interactors of ZIKV envelope (E) protein by combining protein pull-down with mass spectrometry.

The Aedes aegypti Domino Ortholog p400 Regulates Antiviral Exogenous Small Interfering RNA Pathway Activity and Expression.

Arboviruses are pathogens of humans and animals. A better understanding of the interactions between these pathogens and the arthropod vectors, such as mosquitoes, that transmit them is necessary to develop novel control measures. A major antiviral pathway in the mosquito vector is the exogenous small interfering RNA (exo-siRNA) pathway, which is induced by arbovirus-derived double-stranded RNA in infected cells.

Alexithymia, Prior Trauma, Alcohol Use, and Sexual Aggression Perpetration: A Cross-Cultural Comparison of a Moderated Mediation Model.

In this study, we examined the relationships between prior trauma, alexithymia, and sexual aggression perpetration among 610 U.S. college students and 107 college students from the Philippines utilizing a cross-sectional retrospective design.

Long-term displacement associated with health and stress among survivors of Typhoon Haiyan.

Unlabelled: Displacement from one's home after a natural disaster results not only in physical separation from significant others but also in profound disruptions of psychological and social resources such as community support and sense of belonging. Frequent displacement can exacerbate health and mental health problems brought by the disaster, especially among lower-income families in resource-scarce regions.

Objective: The present study examined the association among frequency of displacement after the disaster, health status, and psychological adjustments among survivors four years after the 2013 Super Typhoon Haiyan in the Philippines.

Phase Segregation and Photothermal Remixing of Mixed-Halide Lead Perovskites.

Mixed-halide lead perovskites (MHPs) are promising materials for photovoltaics and optoelectronics due to their highly tunable band gaps. However, they phase segregate under continuous illumination or an electric field, the mechanism of which is still under debate. Herein we systematically measure the phase segregation behavior of polymer-encapsulated CHNHPb(BrI) MHPs as a function of excitation intensity and the nominal halide ratio by in situ photoluminescence microspectroscopy and observe surprising phase dynamics at the beginning of the illumination.

Morphological descriptions and morphometric discriminant function analysis reveal an additional four groups of spp.

There are four species of mud crabs within the genus , and most of them live sympatrically in the equatorial region. Apart from a report in Japan about the finding of a natural hybrid more than a decade ago after the division of genus into four species by Keenan, Davie & Mann (1998), no subsequent sighting was found. Thus, this study investigates the possible natural occurrence of potential hybridization among species in the wild.

Cercarial Fauna of Freshwater Snails in Selected Agricultural Areas in Laguna, Philippines.

Freshwater snails serve as one of trematodes' intermediate hosts. Previous studies on trematode larval stages in the Philippines have largely focused on species with public health importance. This study sought to investigate the prevalence of cercarial morphotypes in several freshwater snail species found in different habitat types (rice field, irrigation canals, and residential area) in selected agricultural areas in Los Baños and Bay in Laguna.

In Silico and In Vitro Assessment of Portuguese Oyster () Proteins as Precursor of Bioactive Peptides.

In this study, the potential bioactivities of Portuguese oyster () proteins were predicted through in silico analyses and confirmed by in vitro tests. proteins were characterized by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and identified by proteomics techniques. Hydrolysis simulation by BIOPEP-UWM database revealed that pepsin (pH > 2) can theoretically release greatest amount of bioactive peptides from proteins, predominantly angiotensin I-converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) inhibitory peptides, followed by stem bromelain and papain.

The Desire to Dissociate Scale: factor analysis, cross-cultural findings, and links to substance-induced dissociation.

Background: Past research identified that a desire for dissociative experiences, rather than dissociative tendencies, mediate the relationship between early sexual abuse and problem drinking in college students. Desire to dissociate was conceptualized as a mechanism facilitating substance-induced dissociation or the use of substances to achieve dissociative-like experiences and was measured using a modified version of the Dissociative Experiences Scale-II. The validity and cross-cultural generalizability of the modified scale are not yet known.

Optimization, isotherm, and kinetic studies of diclofenac removal from aqueous solutions by Fe-Mn binary oxide adsorbents.

Diclofenac (DCF), a widely used non-steroidal anti-inflammatory drug, has been detected in effluents of conventional wastewater treatment plants worldwide. The presence of this compound in various water resources even at very low concentrations poses a big threat both to human health and aquatic ecosystems. In this study, the removal of diclofenac from aqueous solution using Fe-Mn binary oxide (FMBO) adsorbents was investigated.

Baseline study on the levels of heavy metals in seawater and macroalgae near an abandoned mine in Manicani, Guiuan, Eastern Samar, Philippines.

Lateritic nickel ore stockpiles are still present in Manicani Island after mining activities were suspended in 2001. This study aimed to assess the water quality in the island by measuring the levels of Pb, Ni and Cu in seawater and Sargassum polycystum samples collected quarterly in 2018. The levels of the three heavy metals in seawater samples were 0.

Putting the "where" in HIV care: Unpacking narratives of antiretroviral therapy adherence among HIV-Positive men who have sex with men.

This study explores the spatial constitution of adherence to antiretroviral therapy (ART) by recasting therapeutic landscapes (Gesler, 1992) and how it structures the exercise of expressive agency (Bowden, 2014). Engagement in antiretroviral therapy among HIV-positive men who have sex with men (MSM) is contextualized within the discursive-materiality of emplaced assemblages for HIV Care in the Philippines. Combining qualitative data from field visits and semi-structured interviews, three key spatial narratives were derived illustrating how adherence to ART unfolds in place: (a) an unwelcoming treatment hub, (b) an unsafe and safe home, and (c) a constraining workplace.

Evaluation of the bioremediation potential of mud polychaete Marphysa sp. in aquaculture pond sediments.

Organic enrichment from aquaculture could alter the chemical composition of the fishpond bottom by increasing the levels of organic matter (OM), sulfur (S), iron (Fe), and lower pH of the sediment. Polychaetes can contribute to the nutrient cycling and remediation of polluted sediment. A laboratory experiment was conducted to test the remediation potential of small and large mud polychaete Marphysa sp.

In Situ Sensing of Reactive Oxygen Species on Dye-Stained Single DNA Molecules under Illumination.

Reactive oxygen species (ROS) are a necessary evil in many biological systems and have been measured with fluorescent probes at the ensemble levels both in vitro and in vivo. Measuring ROS generated from a single molecule is important for mechanistic studies, yet measuring ROS near a dye-labeled single-molecule under illumination has been challenging. Here, we use CellROX, a group of ROS probes, to sense ROS near dye-stained DNA that has been flow-stretched and immobilized on a surface.

Bioactivities of enzymatic protein hydrolysates derived from .

protein isolates were enzymatically hydrolyzed using pepsin, bromelain, and thermolysin, with their molecular characteristics and bioactivities determined. Thermolysin hydrolysates exhibited the highest degree of hydrolysis (18.08% ± 1.