Nebivolol, an FDA-Approved Drug, Has General Antibacterial and Antibiofilm Effects and Increases Tolerance to Ciprofloxacin.

Background: The repurposing of approved drugs for new activities is gaining widespread attention, including drugs that have antibacterial properties. Nevertheless, besides the benefits of repurposing drugs, the discovery of new antibiotic activity in commonly used medicines raises concerns about inducing antibiotic tolerance and resistance due to the stress produced by the drugs. We found that nebivolol, which is used to treat hypertension, also has antibacterial activity.

Safety and Effectiveness of a Novel Liposomal Intra-Articular Lubricant in Symptomatic Knee Osteoarthritis: A First-in-Human Study.

Osteoarthritis (OA) is a common disease that affects almost half the population at some point in their lives, causing pain and decreased functional capacity. New conservative treatment modalities are being proposed to provide symptomatic relief and delay surgical intervention. This study aimed at evaluating the safety of the novel liposomal boundary lubricant, injected intra-articularly in patients with moderate knee OA.

Pain-Associated Diagnoses in Childhood Before the Diagnosis of Attention-Deficit/Hyperactivity Disorder: A Population-Based Study.

Pediatric pain significantly affects children's lives, leading to school absenteeism, impaired social interactions, and psychological distress. The perception of sensory signals as pain is influenced by the brain's noradrenergic system, and recent evidence suggests that chronic pain may impact cognitive functioning and emotional regulation. Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with alterations in the dopaminergic/noradrenergic systems, which could affect pain perception.

Melanoma Cells from Different Patients Differ in Their Sensitivity to Alpha Radiation-Mediated Killing, Sensitivity Which Correlates with Cell Nuclei Area and Double Strand Breaks.

: In this study, for the first time, we examined and compared the sensitivity of four patient-derived cutaneous melanoma cell lines to alpha radiation in vitro and analyzed it in view of cell nucleus area and the formation of double-strand breaks (DSB). Melanoma cells sensitivity to alpha radiation was compared to photon radiation effects. Furthermore, we compared the sensitivity of the melanoma cells to squamous cell carcinoma.

Disability and Patient-Reported Satisfaction in Women with Idiopathic Intracranial Hypertension: A Comparative Study of Venous Sinus Stenting and Medical Management.

Objective: Patients with chronic idiopathic intracranial hypertension (IIH) commonly experience a high level of disability and low satisfaction with medical treatment. We aim to evaluate long-term functional improvement and patient satisfaction in IIH patients with similar symptoms by comparing venous sinus stenting (VSS) to standard medical therapy.

Methods: We conducted a cross-sectional questionnaire study of 111 IIH patients, comparing 37 adult female patients who underwent venous sinus stenting with 74 patients treated medically.

On the Scaling of Transport Phenomena at a Monotonously Changing Hydraulic Conductivity Field.

Monotonously stratified porous medium, where the layered medium changes its hydraulic conductivity with depth, is present in various systems like tilled soil and peat formation. In this study, the flow pattern within a monotonously stratified porous medium is explored by deriving a non-dimensional number, Fhp, from the macroscopic Darcian-based flow equation. The derived Fhp theoretically classifies the flow equation to be hyperbolic or parabolic, according to the hydraulic head gradient length scale, and the hydraulic conductivity slope and mean.

Effect of pelvic floor fascial mobilization on pelvic floor dysfunction in multiparous pregnant women - A randomized pilot study.

Background: Pelvic floor fascial mobilization (PFFM) is an innovative intravaginal and/or intrarectal manual therapy technique developed to treat pelvic distress by improving fascial gliding and muscle function.

Aim: The effect of PFFM on pelvic floor distress during pregnancy was compared to conventional pelvic floor muscle training.

Methods: A pilot prospective randomized clinical trial.

Ultrasound evaluation of deep fascia thickness: Reliability and association with clinically evaluated changes.

Background: There is growing evidence of fascial involvement in musculoskeletal pathologies; thus, measuring the fascia's properties is clinically essential.

Objectives: 1) to evaluate intra- and inter-tester reliability of sonographic measurements of deep fascia thickness in healthy individuals; 2) to assess whether fascial thickness in areas of fascial movement restriction (fascial densification in Stecco's Fascial Manipulation method), differs from contralateral areas with normal fascia.

Methods: Part 1 (reliability study): Fascial thickness was sonographically measured in 10 sites (5 on each side), twice by a single examiner to assess intra-rater reliability and once by a second examiner to evaluate inter-rater reliability.

Pilates exercises during pregnancy: A narrative review.

Background: The Pilates method has various health benefits, including reducing kinesiophobia, alleviating pain intensity, and improving disability among individuals with low back pain. Additionally, it has been shown to positively impact mental health outcomes such as depression, anxiety, and fatigue. However, the safety and efficacy of practicing Pilates during pregnancy have not been clearly established.

What really makes residents tick or burn out? Insights from a National survey.

Background: To examine the satisfaction rates and burnout feelings amongst residents physicians in different specialties and to examine associated affecting factors.

Method: Clalit Health Services (CHS) is the largest health maintenance provider in Israel. A survey was designed by an interdisciplinary team with questions addressing residency and the balance between residency and personal life, as well as the balance between residency and personal life, and was sent to all residents of CHS via personal email from March to May 2022.

Can Information About Stiffness Perception be Inferred from Action Signals Using Models?

We use sensory feedback to form our perception, and control our movements and forces (actions). There is an ongoing debate about the relation between perception and action, with evidence in both directions. For example, there are cases in which perceptual illusions affect action signals and cases where they do not.

The Impact of Palivizumab for Respiratory Syncytial Virus Prophylaxis on Preschool Childhood Asthma.

Background: The respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants and is associated with an increased risk of asthma development. Palivizumab, an RSV prophylactic, reduces RSV-related hospitalizations in high-risk infants, but its impact on long-term asthma outcomes remains unclear. This study compares asthma-related healthcare utilization in preschool children born prematurely between those who received Palivizumab (the Prophylaxis (+) group) and those who did not (the Prophylaxis (-) group).

PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity.

Adenocarcinomas from multiple tissues can converge to treatment-resistant small cell neuroendocrine (SCN) cancers composed of ASCL1, POU2F3, NEUROD1, and YAP1 subtypes. We investigated how mitochondrial metabolism influences SCN cancer (SCNC) progression. Extensive bioinformatics analyses encompassing thousands of patient tumors and human cancer cell lines uncovered enhanced expression of proliferator-activatedreceptor gamma coactivator 1-alpha (PGC-1α), a potent regulator of mitochondrial oxidative phosphorylation (OXPHOS), across several SCNCs.

Parasite traits, host traits, and environment as determinants of dark diversity affinity in flea and gamasid mite assemblages from the Palearctic.

A species set in a site comprises species that are present (realized diversity) and species that could inhabit this site but are absent (dark diversity; DD). DD can be both species-driven (a species' traits preclude its presence, independently of site features) and site-driven (site features preclude the species' presence, independently of its traits). DD affinity (DDA) is a measure of species' tendencies to be absent from sites that they could inhabit or of sites' tendencies to lack species that could be present.

Shorter vs. standard-duration antibiotic therapy for nocardiosis: a multi-center retrospective cohort study.

Purpose: The prolonged treatment recommended for nocardiosis does not rely on strong evidence. Consequently, some clinicians opt shorter therapy in certain circumstances. We assessed the effectiveness of shorter therapy.

Metacognitive Intervention Facilitating a Growth Mindset for Youth at Risk: The Contribution of Occupational Therapy Practitioners to the Educational Team.

Background: Youth at risk often experience adaptation difficulties. Functional metacognitive interventions, outlined by occupational therapy practitioners, may support their daily performance.

Aim: To examine a metacognitive educational intervention that facilitates a growth mindset and strategy use, with the unique contribution of occupational therapy practitioners to the educational team.

Synchronization of E. coli Bacteria Moving in Coupled Microwells.

Synchronization plays a crucial role in the dynamics of living organisms. Uncovering the mechanism behind it requires an understanding of individual biological oscillators and the coupling forces between them. Here, a single-cell assay is developed that studies rhythmic behavior in the motility of E.

The top 100 most cited articles in acne vulgaris: a bibliometric analysis.

A substantial body of literature has been published on acne vulgaris (AV) in the past five decades. Bibliometric analysis (BA) is a scientific, statistical evaluation review of published articles, providing a quantitative assessment of past research. The Web of Science (webOS) citation indexing database was used on 11 June 2023 to identify the top 100 cited articles on AV.

Association between metabolic and bariatric surgery and malignancy: a systematic review, meta-analysis, trends, and conclusions.

Background: Conflicting studies have investigated the association between obesity, metabolic and bariatric surgery (MBS), and cancer.

Objectives: Our study aimed at elucidating the trends in cancer incidence that are related to obesity and weight loss managed through MBSs, like Colo-rectal, breast, uterine, and esophageal cancer.

Setting: We conducted a search using PubMed, Embase, and the Cochrane Library electronic databases through May 2020.