Research on adverse event classification algorithm of da Vinci surgical robot based on Bert-BiLSTM model.

This study aims to enhance the classification accuracy of adverse events associated with the da Vinci surgical robot through advanced natural language processing techniques, thereby ensuring medical device safety and protecting patient health. Addressing the issues of incomplete and inconsistent adverse event records, we employed a deep learning model that combines BERT and BiLSTM to predict whether adverse event reports resulted in patient harm. We developed the Bert-BiLSTM-Att_dropout model specifically for text classification tasks with small datasets, optimizing the model's generalization ability and key information capture through the integration of dropout and attention mechanisms.

Potential involvement of cuproptosis induced by m6A-modified autophagy gene ATG10 in KICH : Cuproptosis induced by m6A-modified ATG10 in KICH.

Kidney Chromophobe (KICH) is the third most prevalent renal malignancy, with research challenges due to a dearth of cell lines and clinical samples. There is no specific treatment regimen tailored exclusively for KICH. This study employed gene expression analysis, immunohistochemistry (IHC), Spearman's correlation, immune cell infiltration assessment, and molecular network construction to investigate the autophagy gene ATG10 in KICH.

Proliferative potential and angiogenic characteristics of blood outgrowth endothelial cells derived from middle-aged and older adults.

Objectives: Autologous blood outgrowth endothelial cells (BOECs) have been proposed to induce therapeutic angiogenesis for treating cardiovascular diseases (CVDs). The aim of the present study was to investigate the proliferative potential and angiogenic characteristics of BOECs among middle-aged and older adults, the population particularly susceptible to CVDs.

Methods: BOECs were isolated from 48 peripheral blood samples of subjects aged 56 ± 4 years.

Chromatographic differentiation in SOA fingerprint identification: A study on naphthalene and α-pinene oxidation.

The evolution of precursors to form secondary organic aerosol (SOA) is still a challenge in atmospheric chemistry. Chamber experiments were conducted to simulate the ambient OH oxidation of naphthalene and α-pinene, which are typical markers of anthropogenic and biogenic emissions. Particulate matters were sampled by quartz filters and were analyzed by comprehensive two-dimensional gas chromatography (GC×GC) coupled with a thermal desorption system (TD) and a mass spectrometer (MS).

Engineering and construction of multi-functional Janus separator for high-stability Li-CO battery.

Due to the high theoretical energy density, lithium-carbon dioxide (Li-CO) batteries provide unique advantages when using CO to generate electricity. However, the issues with lithium dendrite generated by uneven deposition and quick cathode passivation continue to impede the development of Li-CO batteries. In this work, a Janus separator with dual functionalities is created using an in-situ growth and hydrothermal technique.

Association between fundamental movement skills and accelerometer-measured physical activity in orphan children with severe intellectual disabilities.

Background: Children with intellectual disabilities (ID) typically exhibit low levels of physical activity (PA) and delayed motor skills. Understanding the motor skill factors that influence PA participation in this population is essential for designing effective interventions. The purpose of this study was to examine the association between fundamental motor skills (FMS) and objectively measured PA among orphan children with severe ID residing in welfare institutions.

A novel conformable fractional-order accumulation grey model and its applications in forecasting energy consumption of China.

Accurate forecasting of energy consumption demand is crucial to optimize resources and achieve sustainable development goals. However, the energy system is affected by many factors, which are complex and highly uncertain. Therefore, a novel grey model (IBCFGMP (1,1,N)) is proposed, integrating multiple optimization techniques such as background value optimization, initial condition optimization, fractional-order accumulation optimization, and grey action quantity optimization.

A green method on dipole solvent as "Activators": γ-valerolactone/HO system promoted degradation of ciprofloxacin by ferrate(Ⅵ).

This paper investigates the efficient degradation of ciprofloxacin (CIP) in a sustainable γ-valerolactone (GVL) and water (H₂O) mixed system by controlling proton transfer and reducing the self-decay rate of Fe(VI). The kinetic model reveals that the GVL/H₂O system exhibits a rate constant of (9.7 ± 0.

Widening of Dynamic Detection Range in Real-Time Angular-Interrogation Surface Plasmon Resonance Biosensor Based on Anisotropic Van Der Waals Heterojunction.

Surface plasmon resonance (SPR) biosensors have experienced rapid development in recent years and have been widely applied in various fields. Angular-interrogation SPR biosensors play an important role in the field of biological detection due to their advantages of reliable results and high stability. However, angular-interrogation SPR biosensors also suffer from low detection sensitivity, poor real-time performance, and limited dynamic detection range, which seriously restricts their application and promotion.

Propionate-functionalized chitosan hydrogel nanoparticles for effective oral delivery of insulin.

Oral delivery of macromolecular drugs is often hampered by the harsh gastrointestinal environment, which makes the drugs have poor bioavailability. Insulin, the most used drug for diabetes, also faces the same challenge for oral administration. Hence, we decorated microbial metabolite propionate on chitosan (CS) to fabricate insulin-loaded propionate-modified CS hydrogel nanoparticles (IN-CS/PA HNPs).

Design of semi-open prosthetic socket with constant force for lower limb.

Background: Prosthetic socket is a key component of the prosthesis for clinical application; its performance directly affects the adaptation of the residual limb to the prosthetic socket. There are long-term and short-term volume fluctuation of the residual limb. The volume fluctuation of the residual limb will lead to the pressure mismatch at the interface of the residual limb and the prosthetic socket, which will cause a series of skin and fit problems.

3D Interwoven SiC/g-CN Structure for Superior Charge Separation and CO Photoreduction Performance.

To address the limitations of carbon nitride in photocatalysis, we propose constructing a three-dimensional interwoven SiC/g-CN composite structure. Utilizing the strong microwave-thermal conversion characteristics of SiC whiskers, localized "hot spots" are generated, which induce rapid thermal gradients, promoting rapid polymerization of urea and in situ formation of the interwoven network. This unique structure strengthens the interaction between these two components, creates multiple electron transport pathways, enhances CO adsorption, and effectively improves charge separation while reducing photogenerated carrier recombination.

Integration of Microarray Data and Single-Cell Sequencing Analysis to Explore Key Genes Associated with Macrophage Infiltration in Heart Failure.

Background: Cardiac macrophages are a heterogeneous population with high plasticity and adaptability, and their mechanisms in heart failure (HF) remain poorly elucidated.

Methods: We used single-cell and bulk RNA sequencing data to reveal the heterogeneity of non-cardiomyocytes and assess the immunoreactivity of each subpopulation. Additionally, we employed four integrated machine learning algorithms to identify macrophage-related genes with diagnostic value, and in vivo validation was performed.

ACE Loss Drives Renal Cell Carcinoma Growth and Invasion by Modulating AKT-FOXO1.

Purpose: Emerging literature links the role of the renin-angiotensin-aldosterone system (RAAS) to the progression of cancers. However, the function of RAAS has not been verified in Clear-cell renal cell carcinoma (ccRCC).

Methods: ACE expression in ccRCC tissues was determined using RT-PCR, Western blot, and immunohistochemistry staining.

Spatial metabolomics reveal metabolic alternations in the injured mice kidneys induced by triclocarban treatment.

Triclocarban (TCC) is a common antimicrobial agent that has been widely used in medical care. Given the close association between TCC treatment and metabolic disorders, we assessed whether long-term treatment to TCC at a human-relevant concentration could induce nephrotoxicity by disrupting the metabolic levels in a mouse model. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was applied to investigate the alterations in the spatial distributions and abundances of TCC, endogenous and exogenous metabolites in the kidney after TCC treatment.

Tailoring a Transition Metal Dual-Atom Catalyst via a Screening Descriptor in Li-S Batteries.

The adsorption-conversion paradigm of polysulfides during the sulfur reduction reaction (SRR) is appealing to tackle the shuttle effect in Li-S batteries, especially based upon atomically dispersed electrocatalysts. However, mechanistic insights into such catalytic systems remain ambiguous, limiting the understanding of sulfur electrochemistry and retarding the rational design of available catalysts. Herein, we systematically explore the polysulfide adsorption-conversion essence via a geminal-atom model system to understand the catalyst roles toward an expedited SRR.

Versatility of electrospun Janus wound dressings.

Electrospun nanofibers produced through single-fluid blending processes have successfully demonstrated their potential as highly effective wound dressings. However, electrospun Janus nanofibers, in which various chambers can be designed to load different active pharmaceutical ingredients into different polymeric matrices, are further exhibiting their versatility for promoting wound healing. This commentary declares that wound dressings always need multiple functional performances to promote wound healing.

Nanogel imprinting improving affinity and selectivity of domain-limited ssDNA aptamer to Pb: Interaction mechanisms revealed by molecular dynamics simulation.

Aptamer conformations are susceptible to environmental conditions, which makes it difficult to achieve stable targets detection in complex environments with aptasensors. Imprinting strategy was proposed to immobilize the specific conformation of aptamers, aiming to enhance their recognition anti-interference. However, it is mechanistically unclear how the imprinted polymers affect aptamers' recognition, which limits application of the strategy.

Adjacent-Ligand Tuning of Atomically Precise Cu-Pd Sites Enables Efficient Methanol Electrooxidation with a CO-Free Pathway.

Whether the catalyst can realize the non-CO pathway is the key to greatly improve the catalytic activity and stability of methanol oxidation reaction (MOR). It is feasible to optimize the reaction path selectivity by modifying organic ligands and constructing single-atom systems. At the same time, heterogeneous metal nanosheets with atomic thickness have been shown to significantly enhance the catalytic activity of materials due to their ultra-high exposure of active sites and synergistic effects.

Pupil dilation and behavior as complementary measures of fear response in Mice.

The precise assessment of emotional states in animals under the combined influence of multiple stimuli remains a challenge in neuroscience research. In this study, multi-dimensional assessments, including high-precision pupil tracking and behavioral analysis, were conducted to investigate the combined effects of fear stimuli and drug manipulation on emotional responses in mice. Mice exposed to foot shocks showed typical freezing and flight behaviors, but neither of these measures could effectively distinguish between dexmedetomidine, isoflurane, and saline groups.

Evaluation of two luteal support regimens, intramuscular progesterone and progesterone vaginal gel, for vitrified-warmed embryo transfer in women with chronic salpingitis: a single-center 8-year retrospective study.

Background: Chronic salpingitis is one of the most common causes of female infertility. Luteal support is a critical step for embryo transfer. Here, we evaluated the effects of two luteal support regimens, intramuscular progesterone (IMP) and progesterone vaginal gel (VAG), on the pregnancy outcomes in patients with chronic salpingitis undergoing vitrified-warmed embryo transfer.

A sandwich-type electrochemiluminescence biosensor based on Ni(HAB)/Au@ZnNiAl-LDH/Ru@MIL-53(Al)-NH for ultra-sensitive detection of microRNA-155.

A novel electrochemiluminescence (ECL) biosensor was developed for the ultrasensitive detection of miRNA-155, based on the synergistic combination of multifunctional nanomaterials. The biosensor employed a conductive metal-organic framework (MOF), Ni(HAB) (HAB = hexaaminobenzene), as the substrate material. The unique π-electron conjugated structure of Ni(HAB) endowed the biosensor with excellent electron transport properties, significantly enhancing its sensitivity.

Aberrant expression of messenger and small noncoding RNAomes in aged skin of rats.

The exact mechanisms and key functional molecules involved in skin ageing remain largely unknown. Studies linking the expression of messenger RNAs (mRNAs) and small noncoding RNAs (sncRNAs) to skin ageing are limited. In this study, we performed RNA sequencing to assess the effects of ageing on the expression of mRNAs and sncRNAs in rat skin.

Modulation of Inflammation Levels and the Gut Microbiota in Mice with DSS-Induced Colitis by a Balanced Vegetable Protein Diet.

Inflammatory bowel disease (IBD) is a nonspecific chronic inflammatory disease of the intestine that is mainly divided into ulcerative colitis and Crohn's disease. Nutrients play important roles in the treatment of IBD. In this study, the effects of vegetable proteins on the regulation of IBD were explored via the amino acid scoring formula.