Resinacein S ameliorates the obesity in mice via activating the brown adipose tissue.

Brown adipose tissue (BAT) is an ideal target organ for obesity treatment. Resinacein S is extracted from Ganoderma lucidum and can elevate Uncoupling protein 1 (UCP1) in cells, but its related effects at the animal level are not clear. The mice were fed with high-fat diet to construct obesity models and treated with Resinacein S.

PbsNRs: predict the potential binders and scaffolds for nuclear receptors.

Nuclear receptors (NRs) are a class of essential proteins that regulate the expression of specific genes and are associated with multiple diseases. In silico methods for prescreening potential NR binders with predictive binding ability are highly desired for NR-related drug development but are rarely reported. Here, we present the PbsNRs (Predicting binders and scaffolds for Nuclear Receptors), a user-friendly web server designed to predict the potential NR binders and scaffolds through proteochemometric modeling.

Long-term changes in frailty and incident atrial fibrillation, heart failure, coronary heart disease, and stroke: A prospective follow-up study.

Background: People with frailty have increased prevalence and incidence of atrial fibrillation (AF).

Objective: The study aimed to further investigate the association of long-term changes in frailty with risk of new-onset AF. Its associations with heart failure (HF), coronary heart disease (CHD), and stroke were also evaluated as a secondary aim.

The droplet dynamics of asymmetrical impingement on moving ridged surface.

Hypothesis: The depth of research into the mechanism of droplet impacting structured surfaces dictates the efficacy of their applications. The impact stress generated when a droplet impacts a surface is a pivotal factor influencing the efficiency of surface applications, ultimately determining the extent of surface wear. Despite the systematic examination of impact force, there remains a scarcity of research on impact stress and its mitigation strategies.

Research on the Application of Silver Nanowire-Based Non-Magnetic Transparent Heating Films in SERF Magnetometers.

We propose a non-magnetic transparent heating film based on silver nanowires (Ag-NWs) for application in spin-exchange relaxation-free (SERF) magnetic field measurement devices. To achieve ultra-high sensitivity in atomic magnetometers, the atoms within the alkali metal vapor cell must be maintained in a stable and uniform high-temperature environment. Ag-NWs, as a transparent conductive material with exceptional electrical conductivity, are well suited for this application.

Comparison of Nutritional Flavor Substances in Meat Between Shanghai Local Pig Breeds and Commercial DLY Breed.

Chinese local pig breeds have unique meat flavor. In this study, we investigated the meat quality traits and the characteristics of the nutritional flavor substances such as amino acids (AAs), fatty acids (FAs), thiamine (Vitamin B1, VB1), and inosine monophosphate (IMP) in four Shanghai local pig breeds (MMS, SW, PD, and SHW) and the commercial crossbred Duroc × Landrace × Yorkshire (DLY) breed. The results showed that the intramuscular fat (IMF) and protein content in the longissimus dorsi muscle (L) of Shanghai local breeds, especially Shanghai MMS and PD breeds, were significantly higher than those of the DLY breed (-value < 0.

LuAlO:Ce Fluorescent Ceramic with Deep Traps: Thermoluminescence and Photostimulable Luminescence Properties.

Electron-trapping materials have attracted a lot of attention in the field of optical data storage. However, the lack of suitable trap levels has hindered its development and application in the field of optical data storage. Herein, LuAlO:Ce fluorescent ceramics were developed as the optical storage medium, and high-temperature vacuum sintering induced the formation of deep traps (1.

Comparative impact of exercise variants on depressive symptoms in cancer patients: A systematic review and network meta-analysis.

Purpose: The aim of this study was to conduct a network meta-analysis to assess the effectiveness of various forms of exercise as an intervention for post-cancer depression and to provide a guiding program based on evidence-based medicine for subsequent clinical practice.

Methods: This review was registered on the PROSPERO website with ID CRD42023485407. Pubmed, Embase, Cochrane Library, and Web of Science were comprehensively searched to obtain published articles from the establishment of the database until October 7, 2023.

On-Chip Metamaterial-Enhanced Mid-Infrared Photodetectors with Built-In Encryption Features.

The integration of mid-infrared (MIR) photodetectors with built-in encryption capabilities holds immense promise for advancing secure communications in decentralized networks and compact sensing systems. However, achieving high sensitivity, self-powered operation, and reliable performance at room temperature within a miniaturized form factor remains a formidable challenge, largely due to constraints in MIR light absorption and the intricacies of embedding encryption at the device level. Here, a novel on-chip metamaterial-enhanced, 2D tantalum nickel selenide (Ta₂NiSe₅)-based photodetector, meticulously designed with a custom-engineered plasmonic resonance microstructure to achieve self-powered photodetection in the nanoampere range is unveiled.

Trends in conductive MOFs for sensing: A review.

Metal-organic frameworks (MOFs) are porous, ordered arrays formed by coordination bonds between organic ligands and metal ions or clusters. The highly tunable properties of the MOF structure and performance make it possible to meet the needs of many applications. Conductive MOFs are essential in the domain of sensing due to their electrical conductivity, porosity, and catalytic properties, offering an effective platform for detection.

Sepsis-associated endothelial glycocalyx damage: a review of animal models, clinical evidence, and molecular mechanisms.

In the mammalian cardiovascular system, endothelial glycocalyx is a gel-like layer that covers the luminal surface of endothelial cells (ECs) and plays crucial roles in vascular homeostasis, permeability and leukocyte adhesion. Degradation of this structure occurs early in sepsis and becomes accordingly dysfunctional. In severe cases, it is not self-regulated by the organism.

Quantifying the contributions of factors to bioaccessible Cd and Pb in soil using machine learning.

The bioaccessibility of cadmium (Cd) and lead (Pb) in the gastrointestinal tract is crucial for health risk assessments of contaminated soils. However, variability in In vitro analytical conditions and soil properties introduces bias and uncertainty in predictions. This study employed three in vitro methods to measure Cd and Pb bioaccessibility during the gastric and gastrointestinal phases, using soil samples incubated for one year.

Alzheimer's disease recognition based on waveform and spectral speech signal processing.

Alzheimer's disease (AD) is a neurodegenerative disorder with an irreversible progression. Currently, it is diagnosed using invasive and costly methods, such as cerebrospinal fluid analysis, neuroimaging, and neuropsychological assessments. Recent studies indicate that certain changes in language ability can predict early cognitive decline, highlighting the potential of speech analysis in AD recognition.

Fe, N-CQDs triggered the fabrication of alginate encapsulated g-CN hydrogel for efficient photocatalytic activation of PMS and antibiotic degradation.

Carbon dots (CDs) mediated g-CN (CN) is a promising visible-light-driven semiconductor in catalyzing peroxymonosulfate (PMS) for aqueous contaminants remediation. However, the poor dispersibility of powered catalyst and its challenging recyclability impede their broader application. Herein, we embedded FeN bridge within the g-CN framework and immobilized g-CN gel beads (CA/FNCCN) through a 3D cross-linking process with sodium alginate.

Glutathione depletion-based pH-responsive injectable hydrogels for synergistic treatment of colon tumor.

In this paper, a pH-sensitive chitosan-grafted phenylboronic acid (CS-BA)/polyvinyl alcohol (PVA) hydrogel was constructed based on dynamic borate bonding for loading chemotherapeutic drug cisplatin (CDDP) and divalent Cu (CS-BA/PVA-Cu-CDDP). The hydrogel can respond and degrade specifically in the simulative acidic tumor microenvironment (TME), and the released Cu can deplete glutathione (GSH) in tumor cells and generate Cu. It is worth noting that, Cu can further catalyze the Fenton-like reaction to generate cancer cell-toxic hydroxyl radicals (OH•).

Conductive Hydrogel Systems Enabling Rapid and Controllable Release of Guests at Low-Voltage Region.

Smart delivery materials that respond to electric fields attract interest across various fields, whereas systems enabling rapid, controllable, and safe delivery capabilities remain essential. Based on the hypothesis of utilizing electric field to manipulate inter-component noncovalent bonds in delivery materials, a hydrogel system is hereby reported that is capable of achieving rapid guest release at low-voltage region. This system harnesses the synergistic regulation of electric field-induced host-guest electrostatic repulsion, alongside the dynamic modulation of H-bond interactions within the conductive hydrogel.

Simulation Study of Envelope Wave Electrical Nerve Stimulation Based on a Real Head Model.

In recent years, the modulation of brain neural activity by applied electromagnetic fields has become a hot spot in neuroscience research. Transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) are two common non-invasive neuromodulation techniques. However, conventional tACS has limited stimulation effects in the deeper parts of the brain.

Research on the application of functional near-infrared spectroscopy in differentiating subjective cognitive decline and mild cognitive impairment.

Introduction: Alzheimer's disease (AD) is a common neurological disorder. Based on clinical characteristics, it can be categorized into normal cognition (NC), subjective cognitive decline (SCD), mild cognitive impairment (MCI), and dementia (AD). Once the condition begins to progress, the process is usually irreversible.

Electrochemo-Mechanical Degradation and Failure of Active Particles in High Energy Density Batteries: A Review.

Failure of the active particles is inherently electrochemo-mechanics dominated. This review comprehensively examines the electrochemo-mechanical degradation and failure mechanisms of active particles in high-energy density lithium-ion batteries. The study delves into the growth of passivating layers, such as the solid electrolyte interphase (SEI), and their impact on battery performance.

Progress and perspectives on electrocatalysis in room-temperature Na-S batteries.

Room-temperature sodium-sulfur (RT Na-S) batteries that typically feature multielectron conversion chemistries can allow an ultrahigh specific capacity of 1675 mA h g and a high energy density of 1275 W h kg but unfortunately suffer from a lot of intractable challenges from sulfur cathodes. These issues cover the poor electronic conductivity of pristine sulfur and solid products, the severe shuttle effect of polysulfides, and the sluggish redox kinetics, The shuttling behavior of polysulfides always leads to cathode/anode instability and performance degeneration. Recently, the emerging catalysis strategy has been demonstrated as a reliable pathway to tackle the central issues caused by sulfur electrochemistry and revitalize RT Na-S batteries.

Advances in Exercise and Dietary Interventions for Peripheral Arterial Disease.

Peripheral arterial disease(PAD)is a common atherosclerotic cardiovascular disease.The patients with this disease experience pain during exercise,which is relieved after rest.Exercise interventions,dietary interventions,and combined interventions can treat PAD via different mechanisms.

Large stroke radially oriented MXene composite fiber tensile artificial muscles.

Actuation is normally dramatically enhanced by introducing so much yarn fiber twist that the fiber becomes fully coiled. In contrast, we found that usefully high muscle strokes and contractile work capacities can be obtained for non-twisted MXene (TiCT) fibers comprising MXene nanosheets that are stacked in the fiber direction. The MXene fiber artificial muscles are called MFAMs.

Enhanced Gaussian Process Model for Predicting Compressive Strength of Ultra-High-Performance Concrete (UHPC).

Ultra-high-performance concrete (UHPC) is widely used in engineering due to its exceptional mechanical properties, particularly compressive strength. Accurate prediction of the compressive strength is critical for optimizing mix proportions but remains challenging due to data dispersion, limited data availability, and complex material interactions. This study enhances the Gaussian Process (GP) model to address these challenges by incorporating Singular Value Decomposition (SVD) and Kalman Filtering and Smoothing (KF/KS).

A Dual-Branch Residual Network with Attention Mechanisms for Enhanced Classification of Vaginal Lesions in Colposcopic Images.

Vaginal intraepithelial neoplasia (VAIN), linked to HPV infection, is a condition that is often overlooked during colposcopy, especially in the vaginal vault area, as clinicians tend to focus more on cervical lesions. This oversight can lead to missed or delayed diagnosis and treatment for patients with VAIN. Timely and accurate classification of VAIN plays a crucial role in the evaluation of vaginal lesions and the formulation of effective diagnostic approaches.

Preparation of Antioxidant Peptides from Chicken Bone Proteins and the Influence of Their Compositional Characteristics on Antioxidant Activity.

Antioxidants play an important role in maintaining health and enhancing food stability by neutralizing free radicals. This study aimed to extract antioxidant peptides from white-feathered chicken bones through enzymatic hydrolysis, optimize the enzymatic hydrolysis conditions, and further investigate the relevance between the amino acid composition, molecular weight, and antioxidant activity of the resulting chicken bone hydrolysate. Alcalase was the most effective enzyme for hydrolyzing cooked chicken bones compared with papain, pepsin, and trypsin, yielding hydrolysates with the highest DH and ABTS radical scavenging activity.