"We are doing it together, don't worry" - A qualitative study on the implementation of electronic medical records in German hospitals.

Background: The ongoing implementation of electronic medical records (EMRs) in German hospitals is currently slow. Implementation science widely acknowledges the barriers and facilitators to implementation. Thus, specific preconditions are necessary to address the former and to support an effective EMR implementation.

Mechanisms of concentration control alkali activated fly ash stabilized saline soil in seasonally frozen regions.

In the framework of sustainable development and environmental preservation, this research aims to improve the stability and frost resistance of sulfate saline soil by utilizing industrial solid waste. Geopolymer materials containing fly ash (FA) activated by different NaOH concentrations were studied for study on stabilized soil with saline soil, with NaOH concentrations used ranged from 0.1 to 0.

Value-Based Indication-Specific Pricing and Weighted-Average Pricing: Estimated Price and Cost Savings for Cancer Drugs.

Objectives: For US Medicare and Medicaid, single drug prices do not reflect the value of supplemental indications. Value-based indication-specific and weighted-average pricing has been suggested for drugs with multiple indications. Under indication-specific pricing, a distinct price is assigned to the differential value a drug offers in each indication.

Dysfunctional copper homeostasis in affects genomic and neuronal stability.

While copper (Cu) is an essential trace element for biological systems due to its redox properties, excess levels may lead to adverse effects partly due to overproduction of reactive species. Thus, a tightly regulated Cu homeostasis is crucial for health. Cu dyshomeostasis and elevated labile Cu levels are associated with oxidative stress and neurodegenerative disorders, but the underlying mechanisms have yet to be fully characterized.

Excessive health behaviors in sports: links of orthorexia nervosa and exercise addiction with well-being, exercise activity in sports categories, and gender effects.

Background And Aims: Orthorexia nervosa (OrNe), the obsessive fixation on healthy eating, and exercise addiction (ExAdd) have been discussed as correlated excessive health behaviors with potential mental health implications. The role of gender-and sports-specific differences remains unclear. This study aimed to investigate the links of ExAdd, OrNe, and the non-pathological interest in healthy eating (healthy orthorexia; HeOr) with well-being and exercise activity in various sports, considering gender effects.

The influence of severity of hemophilia on bone mineral density and fracture risk.

Background: Evidence states that persons with hemophilia are frequently affected by low bone mineral density (BMD). Data assessing the relationship between severity of hemophilia and occurrence of osteoporosis are lacking.

Objectives: This prospective cohort study aimed to assess the impact of hemophilia severity on BMD and to investigate trabecular bone score (TBS) and fracture risk (FRAX).

Silver-Catalyzed Aqueous Electrochemical Valorization of Soda Lignin into Aliphatics and Phenolics.

Transitioning from crude oil to renewable sources of carbon-based chemicals is critical for advancing sustainable development. Lignin, a wood-derived biomacromolecule, holds great potential as a renewable feedstock, but efficient depolymerization and dearomatization methods are required to fully unlock its potential. In this investigation, we present a silver-catalyzed aqueous electrocatalytic method for the selective depolymerization and partial dearomatization of soda lignin under mild, ambient conditions.

Cellular mechanisms of copper neurotoxicity in human, differentiated neurons.

Copper (Cu) is an essential trace element involved in fundamental physiological processes in the human body. Even slight disturbances in the physiological Cu homeostasis are associated with the manifestation of neurodegenerative diseases. While suggesting a crucial role of Cu in the pathogenesis, the exact mechanisms of Cu neurotoxicity involved in the onset and progression of neurological diseases are far from understood.

Effects of a Mindfulness-Based Intervention on Event-Related Potentials (P3) and Depressive Symptoms in Oncological Patients.

The aim of this study was to investigate changes in P3 amplitude and latency to emotional stimuli with different arousal and valence levels after a mindfulness-based intervention in oncological patients. P3 amplitude and latency at Fz, Cz, and Pz to emotional salient stimuli differing in valence (positive vs. negative) and arousal (low vs.

Evaluation and spatiotemporal evolution of veterinary talent competitiveness: a new perspective of veterinary education.

Introduction: Improving the quantity and quality of veterinary talent cultivation is an urgent issue to address in current veterinary education and is key to enhancing veterinary talent competitiveness. Starting from an industrial perspective, the introduction of scientific analytical methods for studying veterinary talent competitiveness offers a new view on veterinary education and helps to improve the quality of veterinary education and talent cultivation.

Methods: This study develops a veterinary talent competitiveness evaluation index based on the characteristics of veterinary talent.

An Optimized Ex Vivo n-3 PUFA Supplementation Strategy for Primary Human Macrophages Shows That DHA Suppresses Prostaglandin E2 Formation.

Evidence suggests beneficial effects of long-chain n-3 polyunsaturated fatty acids (PUFAs) in inflammatory diseases. However, the underlying mechanisms are still subject of research. For this purpose, we developed an ex vivo n-3 PUFA supplementation strategy.

Measurement of the electric potential and the magnetic field in the shifted analysing plane of the KATRIN experiment.

The projected sensitivity of the effective electron neutrino-mass measurement with the KATRIN experiment is below 0.3 eV (90 % CL) after 5 years of data acquisition. The sensitivity is affected by the increased rate of the background electrons from KATRIN's main spectrometer.

Dependability of individualized Direct Behavior Rating Multi-Item Scales (DBR-MIS) for academic enablers.

The present study examined the dependability of three newly developed direct behavior rating multi-item scales (DBR-MIS) of academic enablers (i.e., academic engagement, interpersonal skills, and study skills).

Revealing mercury species-specific transfer and toxicity mechanisms in placental trophoblasts.

Environmental mercury (Hg) follows a biogeochemical cycle resulting in a variety of Hg species. Therefore, human exposure to the three Hg species inorganic Hg via crops and air, methyl Hg through fish consumption and ethyl Hg due to the use as antiseptic agent in medical applications is a rising concern. Especially pregnant women and their developing fetus present a vulnerable population.

Six weeks of polarized functional interval training with large training load reductions does not affect performance gains compared to traditional workouts.

Purpose: High-intensity functional interval training (HIFT) is predominantly composed of high exercise training intensities (HiT) and loads. Both have been linked to a higher risk of overtraining and injuries in inexperienced populations. A polarized training approach is characterized by high amounts of low-intensity training (LiT) and only approximately 5%-20% HiT.

Agential realism as an alternative philosophy of science perspective for quantitative psychology.

This paper introduces Karen Barad's philosophical framework of agential realism as an alternative philosophy of science perspective for quantitative psychology and measurement. Agential realism offers a rethinking of the research object, measurement process and outcome, causality, and the researcher's responsibility by proposing an ethico-epistem-ontological understanding of material-discursive practices that co-construct our world. The contemporary, canonical underlying philosophy of science perspective of quantitative psychology entails entity realism, a difference between ontic existence and epistemic approaches, complete causality, and determinism.

A Blended Learning Course on the Diagnostics of Mental Disorders: Multicenter Cluster Randomized Noninferiority Trial.

Background: Clinical diagnoses determine if and how therapists treat their patients. As misdiagnoses can have severe adverse effects, disseminating evidence-based diagnostic skills into clinical practice is highly important.

Objective: This study aimed to develop and evaluate a blended learning course in a multicenter cluster randomized controlled trial.