4 results match your criteria: "University of Wisconsin-Madison Osteoporosis Clinical Center and Research Program[Affiliation]"
Romosozumab Treatment in Postmenopausal Women with Osteoporosis.
N Engl J Med
October 2016
From Helen Hayes Hospital, West Haverstraw, and Columbia University, New York (F.C.) - both in New York; Amgen, Thousand Oaks, CA (D.B.C., C.E.M., L.C., J.M., A.G.); McMaster University, Hamilton, ON, Canada (J.D.A.); University of Wisconsin-Madison Osteoporosis Clinical Center and Research Program, Madison (N.B.); Krakow Medical Center, Krakow, Poland (E.C.); Geneva University Hospital, Geneva (S.F.); the Division of Endocrinology, Diabetes, and Bone Diseases, Center for Healthy Aging, Technische Universität Dresden Medical Center, Dresden, Germany (L.C.H.); the Center for Clinical and Basic Research, Hong Kong (E.L.); New Mexico Clinical Research and Osteoporosis Center, Albuquerque (E.M.L.); Miyauchi Medical Center, Osaka, Japan (A.M.); Centro Paulista de Investigação Clinica, São Paulo (C.A.F.Z.); and UCB Pharma, Brussels (P.D.M., C.L.).
Background: Romosozumab, a monoclonal antibody that binds sclerostin, increases bone formation and decreases bone resorption.
Methods: We enrolled 7180 postmenopausal women who had a T score of -2.5 to -3.
Denosumab compared with ibandronate in postmenopausal women previously treated with bisphosphonate therapy: a randomized open-label trial.
Obstet Gynecol
June 2013
United Osteoporosis Centers, Gainesville, Georgia; Medical College Jagiellonian University, Krakow, Poland; Michigan Bone and Mineral Clinic, Detroit, Michigan; the Clinical Research Center of North Texas, Denton, Texas; the University of Wisconsin-Madison Osteoporosis Clinical Center and Research Program, Madison, Wisconsin; the Palacios Institute of Woman's Health, Madrid, Spain; OB-GYN Associates of Mid Florida, PA, Leesburg, Florida; Amgen Inc, Thousand Oaks, California; Amgen Ltd, Cambridge, United Kingdom; Ovatech Solutions Ltd, London, United Kingdom; The Bethesda Health Research Center, Bethesda, Maryland; and Institut National de la Santé et de la Recherche Médicale (INSERM) U658, CHR d'Orléans, Orléans, France.
Objective: To compare the efficacy and safety of denosumab to ibandronate in postmenopausal women with low bone mineral density (BMD) previously treated with a bisphosphonate.
Methods: In a randomized, open-label study, postmenopausal women received 60 mg denosumab subcutaneously every 6 months (n=417) or 150 mg ibandronate orally every month (n=416) for 12 months. End points included percentage change from baseline in total hip, femoral neck, and lumbar spine BMD at month 12 and percentage change from baseline in serum C-telopeptide at months 1 and 6 in a substudy.
Low vitamin D status: definition, prevalence, consequences, and correction.
Rheum Dis Clin North Am
February 2012
University of Wisconsin-Madison Osteoporosis Clinical Center and Research Program, Madison, WI 53705, USA.
Low vitamin D status is extremely common worldwide due to low dietary intake and low skin production. Suboptimal vitamin D status contributes to many conditions, including osteomalacia/rickets, osteoporosis, falls, and fractures. It is possible or even likely that low vitamin D status increases risk for a multitude of other conditions.
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Endocrinol Metab Clin North Am
June 2010
University of Wisconsin-Madison Osteoporosis Clinical Center and Research Program, Madison, WI 53705, USA.
Vitamin D is obtained from cutaneous production when 7-dehydrocholesterol is converted to vitamin D(3) (cholecalciferol) by ultraviolet B radiation or by oral intake of vitamin D(2) (ergocalciferol) and D(3). An individual's vitamin D status is best evaluated by measuring the circulating 25-hydroxyvitamin D (25(OH)D) concentration. Although controversy surrounds the definition of low vitamin D status, there is increasing agreement that the optimal circulating 25(OH)D level should be approximately 30 to 32 ng/mL or above.
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