4 results match your criteria: "University of Wisconsin-Madison Alzheimer's Disease Research Center[Affiliation]"
Characterizing the emergence of amyloid and tau burden in Down syndrome.
Alzheimers Dement
January 2024
University of Wisconsin-Madison Waisman Center, Madison, Wisconsin, USA.
Article Synopsis
- Individuals with Down syndrome are almost guaranteed to develop Alzheimer's disease, making it crucial to study biomarkers related to the disease for effective clinical interventions.
- A study involving 177 adults with Down syndrome used advanced imaging techniques to monitor amyloid-beta and tau proteins, finding that elevated tau levels occurred in all brain regions where NFTs (neurofibrillary tangles) develop after amyloid positivity.
- The research shows that amyloid accumulates rapidly in Down syndrome, with tau increases appearing soon after—a finding that helps to chart the progression of Alzheimer's specifically in this population, rather than relying on age alone.
Neurofibrillary tau depositions emerge with subthreshold cerebral beta-amyloidosis in down syndrome.
Neuroimage Clin
September 2021
University of Wisconsin-Madison Waisman Center, Madison, WI, USA; University of Wisconsin-Madison Department of Medical Physics, Madison, WI, USA.
Introduction: Adults with Down syndrome are genetically predisposed to develop Alzheimer's disease and accumulate beta-amyloid plaques (Aβ) early in life. While Aβ has been heavily studied in Down syndrome, its relationship with neurofibrillary tau is less understood. The aim of this study was to evaluate neurofibrillary tau deposition in individuals with Down syndrome with varying levels of Aβ burden.
View Article and Find Full Text PDFIntroduction: Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and the relationship between cognition and glucose metabolism in this population has yet to be evaluated.
Methods: Adults with DS (N = 90; mean age [standard deviation] = 38.0 [8.
: Informed consent (IC) is critical to performing ethical research. Unfortunately, the IC process and supporting IC forms are frequently burdensome and do not necessarily meet the informational needs of participants. The intersecting legal and ethical challenges of obtaining IC from individuals with memory or cognitive deficits further exacerbate existing IC shortcomings.
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