Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy.

Tissue-engineered vascular conduits (TEVCs) are a promising blood vessel replacement. In a recent publication in Cell Stem Cell, Park et al. developed TEVCs comprised of decellularized human umbilical arteries lined with shear-trained, human induced pluripotent stem cell (hiPSC)-derived endothelial cells (ECs) that resisted thrombosis and exhibited patency upon grafting into the rat inferior vena cava (IVC).

The crescent sign on ocular ultrasound and correlation with elevated intracranial pressure: A prospective cohort study.

Objectives: While lumbar puncture (LP) remains gold standard for assessing intracranial pressure (ICP), LP can be difficult to perform and lead to complications. Noninvasive correlations for elevated ICP via ocular ultrasound (OUS) have shown mixed results. The primary objective of this study is to identify the frequency and test characteristics of the crescent sign on OUS for elevated ICP.

Vascular endothelial growth factor receptor-1 (FLT1) interactions with amyloid-beta in Alzheimer's disease: A putative biomarker of amyloid-induced vascular damage.

We have identified FLT1 as a protein that changes during Alzheimer's disease (AD) whereby higher brain protein levels are associated with more amyloid, more tau, and faster longitudinal cognitive decline. Given FLT1's role in angiogenesis and immune activation, we hypothesized that FLT1 is upregulated in response to amyloid pathology, driving a vascular-immune cascade resulting in neurodegeneration and cognitive decline. We sought to determine (1) if in vivo FLT1 levels (CSF and plasma) associate with biomarkers of AD neuropathology or differ between diagnostic staging in an aged cohort enriched for early disease, and (2) whether FLT1 expression interacts with amyloid on downstream outcomes, such as phosphorylated tau levels and cognitive performance.

Development of KRAS Inhibitors and Their Role for Metastatic Colorectal Cancer.

Colorectal cancer (CRC) is a heterogeneous group of diseases comprising several molecular subtypes. Comprehensive DNA sequencing is now standard practice to identify these subtype. Until recently, KRAS mutation status in metastatic CRC was primarily used as a biomarker to predict resistance to EGFR inhibition.

Employing foreign caregivers: A qualitative study of the perspectives of older stroke survivors.

Background: Global populations are aging, and the numbers of stroke survivors is increasing. Consequently, the need for caregiver support has increased. Because of this and demographic and socioeconomic changes, foreign caregivers are increasingly in demand in many developed countries.

Influence of BMI on robotic rectal cancer surgery: a systematic review and meta-analysis.

Obesity presents a significant public health challenge, known to escalate the risk of colorectal cancer twofold. The potential advantages of employing robotic technology in colorectal surgery for obese individuals remain mostly unexplored. A comprehensive search of articles retrieved from Scopus, PubMed, and the Cochrane Library for the duration of January 2014 to March 2024 was performed, without language limitations.

Spin Drag Mechanism of Giant Thermal Magnetoresistance.

We study hydrodynamic thermal transport in high-mobility two-dimensional electron systems placed in an in-plane magnetic field and identify a new mechanism of thermal magnetotransport. This mechanism is caused by drag between the electron populations with opposite spin polarization, which arises in the presence of a hydrodynamic flow of heat. In high mobility systems, spin drag results in strong thermal magnetoresistance, which becomes of the order of 100% at relatively small spin polarization of the electron liquid.

Aging With Long-Term Physical Disabilities and Its Implications for Nursing: A Scoping Review.

Aim: To synthesise literature on the aging characteristics of people with long-term physical disabilities and inform future nursing research, education, practice and health policy.

Design: Scoping review.

Data Source: Literature searches were performed in the CINAHL, PubMed, and PsycINFO databases in April 2024.

The Privilege of Well-Being in an Increasingly Unequal Society.

This article provides an overview of a model of psychological well-being put forth over 30 years ago. The intent was to advance new dimensions of positive functioning based on integration of clinical, developmental, existential, and humanistic thinking, along with Aristotle's writings about eudaimonia. The operationalization and validation of the model are briefly described, followed by an overview of scientific findings organized around: (1) demographic and experiential predictors of well-being; (2) well-being as predictors of health and biomedical outcomes; (3) pathway studies that examine intervening processes (moderators, mediators); and (4) underlying mechanistic processes (neuroscience, genomics).

Prostatic Escherichia coli infection drives CCR2-dependent recruitment of fibrocytes and collagen production.

Prostate fibrosis contributes to lower urinary tract dysfunction (LUTD). To develop targeted treatments for prostate fibrosis, it is necessary to identify the cell types and molecular pathways required for collagen production. We used a genetic approach to label and track potential collagen-producing cell lineages in mouse prostate through a round of Escherichia coli UTI89-mediated prostate inflammation.

The impact of common and rare genetic variants on bradyarrhythmia development.

To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respectively.

Varying pixel resolution significantly improves deep learning-based carotid plaque histology segmentation.

Carotid plaques-the buildup of cholesterol, calcium, cellular debris, and fibrous tissues in carotid arteries-can rupture, release microemboli into the cerebral vasculature and cause strokes. The likelihood of a plaque rupturing is thought to be associated with its composition (i.e.

Surface remodeling and inversion of cell-matrix interactions underlie community recognition and dispersal in Vibrio cholerae biofilms.

Biofilms are ubiquitous surface-associated bacterial communities embedded in an extracellular matrix. It is commonly assumed that biofilm cells are glued together by the matrix; however, how the specific biochemistry of matrix components affects the cell-matrix interactions and how these interactions vary during biofilm growth remain unclear. Here, we investigate cell-matrix interactions in Vibrio cholerae, the causative agent of cholera.

Synergistic enhancement of electrochemical alcohol oxidation by combining NiV-layered double hydroxide with an aminoxyl radical.

Electrochemical alcohol oxidation (EAO) represents an effective method for the production of high-value carbonyl products. However, its industrial viability is hindered by suboptimal efficiency stemming from low reaction rates. Here, we present a synergistic electrocatalysis approach that integrates an active electrode and aminoxyl radical to enhance the performance of EAO.

Changes in Youth Mental Health Following a School Lockdown due to Violent and Firearm-Related Threats.

Background: School shooting events and lockdowns have increased in the United States, raising concerns about their impact on youth mental health.

Method: This study assessed the association between school lockdowns and changes in youth mental health in 10,049 children who participated in the Adolescent Brain and Cognitive Development study. The exposure was school lockdowns related to violence and shooting incidents, and the outcomes were Child Behavior Checklist scores on five mental health disorders.

Too Soon to Breathe Easy: Trends in Asbestosis Morbidity and Mortality in Wisconsin.

Objectives: This study aimed to describe asbestosis morbidity and mortality in two statewide samples. We considered trends, demographic disparities, and excess mortality.

Methods: We assessed trends and demographic differences in asbestosis morbidity using hospital and emergency department (ED) visits.

Proposing Bromo-epi-androsterone (BEA) for perioperative neurocognitive disorders with Interleukin-6 as a druggable target.

Cognitive impairment following surgery is a significant complication, affecting multiple neurocognitive domains. The term "perioperative neurocognitive disorders" (PND) is recommended to encompass this entity. Individuals who develop PND are typically older and have increases in serum and brain pro-inflammatory cytokines notwithstanding the type of surgery undergone.

Uniting theory and data: the promise and challenge of creating an honest model of facial expression.

People routinely use facial expressions to communicate successfully and to regulate other's behaviour, yet modelling the form and meaning of these facial behaviours has proven surprisingly complex. One reason for this difficulty may lie in an over-reliance on the assumptions inherent in existing theories of facial expression - specifically that (1) there is a putative set of facial expressions that signal an internal state of emotion, (2) patterns of facial movement have been empirically linked to the prototypical emotions in this set, and (3) static, non-social, posed images from convenience samples are adequate to validate the first two assumptions. These assumptions have guided the creation of datasets, which are then used to train unrepresentative computational models of facial expression.

Preliminary Examination of the Stability of Sequential Associations Between the Talk of Educators and Autistic Preschoolers Using Generalizability Theory.

Purpose: Estimating the sequential associations between educators' and children's talk during language learning interactions requires careful consideration of factors that may impact measurement stability and resultant inferences. This research note will describe a preliminary study that used generalizability theory to understand the contribution of two measurement conditions- and -on estimates of sequential associations between educator talk and autistic preschooler talk in inclusive preschool classrooms.

Method: We used an existing data set of four 15-min video-recorded occasions of educator-child interactions for 11 autistic preschoolers during free-play in their inclusive classroom.

Interactions between epithelial mesenchymal plasticity, barrier dysfunction and innate immune pathways shape the genesis of allergic airway disease.

Introduction: In genetically predisposed individuals, exposure to aeroallergens and infections from RNA viruses shape epithelial barrier function, leading to Allergic Asthma (AA). Here, activated pattern recognition receptors (PRRs) in lower airway sentinel cells signal epithelial injury-repair pathways leading to cell-state changes [epithelial mesenchymal plasticity (EMP)], barrier disruption and sensitization.

Areas Covered: 1.

Intracellular metal ion-based chemistry for programmed cell death.

Intracellular metal ions play essential roles in multiple physiological processes, including catalytic action, diverse cellular processes, intracellular signaling, and electron transfer. It is crucial to maintain intracellular metal ion homeostasis which is achieved by the subtle balance of storage and release of metal ions intracellularly along with the influx and efflux of metal ions at the interface of the cell membrane. Dysregulation of intracellular metal ions has been identified as a key mechanism in triggering programmed cell death (PCD).

Neuroethical considerations and attitudes about neurostimulation as a fatigue countermeasure among emergency responders.

Introduction: First responders play a pivotal role in ensuring the wellbeing of individuals during critical situations. The demanding nature of their work exposes them to prolonged shifts and unpredictable situations, leading to elevated fatigue levels. Modern countermeasures to fatigue do not provide the best results.

The progression of basaltic-rhyolitic melt storage at Yellowstone Caldera.

Yellowstone Caldera is one of the largest volcanic systems on Earth, hosting three major caldera-forming eruptions in the past two million years, interspersed with periods of less explosive, smaller-volume eruptions. Caldera-forming eruptions at Yellowstone are sourced by rhyolitic melts stored within the mid- to upper crust. Seismic tomography studies have suggested that a broad region of rhyolitic melt extends beneath Yellowstone Caldera, with an estimated melt volume that is one to four times greater than the eruptive volume of the largest past caldera-forming eruption, and an estimated melt fraction of 6-28 per cent.

Pre-excitation alternans in a cat.

A nine-year-old male neutered domestic shorthair cat presented on referral for evaluation. The cat presented to its primary veterinarian for acute onset vomiting, panting, and weakness. An electrocardiogram performed at the regular veterinarian was concerning for ventricular tachycardia, and the cat was referred for further evaluation.