2 results match your criteria: "University of Wisconsin School of Medicine andPublic Health[Affiliation]"
The human macrophage sodium channel NaV1.5 regulates mycobacteria processing through organelle polarization and localized calcium oscillations.
FEMS Immunol Med Microbiol
December 2011
The Departments of Neurology, University of Wisconsin School of Medicine andPublic Health, Madison, USA.
Article Synopsis
- Phagocytosis and intracellular processing of mycobacteria in macrophages involve precise coordination of various cellular activities, including uptake, signaling, and organelle movement.
- Recent findings indicate that the voltage-gated sodium channel NaV1.5 enhances endosomal acidification and phagocytosis in human macrophages.
- Knockdown of NaV1.5 impairs the uptake of mycobacteria and disrupts calcium signaling during phagosome maturation, highlighting the importance of this channel in regulating macrophage responses.
Phylogenetic conservation and homology modeling help reveal a novel domain within the budding yeast heterochromatin protein Sir1.
Mol Cell Biol
February 2009
Department of Biomolecular Chemistry, University of Wisconsin School of Medicine andPublic Health, Madison, Wisconsin 53706-1532, USA.
The yeast Sir1 protein's ability to bind and silence the cryptic mating-type locus HMRa requires a protein-protein interaction between Sir1 and the origin recognition complex (ORC). A domain within the C-terminal half of Sir1, the Sir1 ORC interaction region (Sir1OIR), and the conserved bromo-adjacent homology (BAH) domain within Orc1, the largest subunit of ORC, mediate this interaction. The structure of the Sir1OIR-Orc1BAH complex is known.
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