Chemokine Receptor N-Terminus Charge Dictates Reliance on Post-Translational Modifications for Effective Ligand Capture and Following Boosting by Defense Peptides.

The chemokine receptors CCR1 and CCR5 display overlapping expression patterns and ligand dependency. Here we find that ligand activation of CCR5, not CCR1, is dependent on N-terminal receptor O-glycosylation. Release from O-glycosylation dependency is obtained by increasing CCR5 N-terminus acidity to the level of CCR1.

Time of day dependent changes in embryonic heart rate are detectable after maturation of rhythmic circadian gene expression in the eye, but before the heart in tadpoles cultured in LD.

We systematically characterized onset of expression of circadian genes in the embryonic eye and heart of tadpoles. We found that and ( were the first circadian genes to display significant 24-hour rhythms in the developing eye and heart in a 12-hour light-dark cycle (LD). Rhythmic expression of both oscillator and output genes were present in the eye by 2.

Measurement of basic psychological needs for physical activity participation for college students with intellectual disabilities: A validation study.

Background: Measurement instruments to understand self-determined motivation towards physical activity among college students with intellectual disabilities are needed to develop programs to support physical and psychological health and well-being. The purpose of the current study was to validate a modified questionnaire measuring basic psychological needs towards physical activity among college students with intellectual disabilities.

Methods: A total of 108 college students with intellectual disabilities completed the modified questionnaire.

Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood.

Background: Ashwagandha has been reported to reduce stress and attenuate cognitive decline associated with inflammation and neurodegeneration in clinical populations. However, the effects as a potential nootropic nutrient in younger populations are unclear. This study examined the effects of liposomal ashwagandha supplementation on cognitive function, mood, and markers of health and safety in healthy young men and women.

"They Mostly Preached Abstinence Which Didn't Work": Young Adults' Perception of Sex-Related Messages from Caregivers Prior to Initiation of Sex.

Parental communication about sex is an important aspect of sexual socialization. However, research has primarily focused on sexual communication's presence, frequency, or topics, with less research on the specific messages parents communicate. Further, few studies have differentiated between communication received before and after youth initiated sex.

Nonpharmacological pain management approaches among U.S. construction workers: A cross-sectional pilot study.

Background: U.S. construction workers experience high rates of injury that can lead to chronic pain.

Most nearby young star clusters formed in three massive complexes.

Efforts to unveil the structure of the local interstellar medium and its recent star-formation history have spanned the past 70 years (refs. ). Recent studies using precise data from space astrometry missions have revealed nearby, newly formed star clusters with connected origins.

Promoting Reciprocal Relationships with Flexibility, Coaching, and Teaching (PRRFCT Match): A Virtual Parent-Mediated Intervention Package for Young Children with Developmental Disabilities.

This study aimed to evaluate Promoting Reciprocal Relationships with Flexibility, Coaching, and Teaching (PRRFCT Match), a parent-mediated naturalistic developmental behavioral intervention package. An expansion from an earlier pilot study (see Kunze et al., 2021), PRRFCT Match incorporates virtual coaching between a novice coach and parent to implement evidence-based, applied behavior analytic (ABA) techniques during play to increase engagement and decrease unengaged behavior exhibited by their young child with developmental delays (26-50 months old).

Paraxanthine provides greater improvement in cognitive function than caffeine after performing a 10-km run.

Rationale: Intense exercise promotes fatigue and can impair cognitive function, particularly toward the end of competition when decision-making is often critical for success. For this reason, athletes often ingest caffeinated energy drinks prior to or during exercise to help them maintain focus, reaction time, and cognitive function during competition. However, caffeine habituation and genetic sensitivity to caffeine (CA) limit efficacy.

SNAPSHOT USA 2021: A third coordinated national camera trap survey of the United States.

SNAPSHOT USA is a multicontributor, long-term camera trap survey designed to survey mammals across the United States. Participants are recruited through community networks and directly through a website application (https://www.snapshot-usa.

"It's an ongoing discussion about desire": Adults' strategies for managing sexual and affectionate desire discrepancies in romantic relationships.

Desire discrepancies are a common source of relationship conflict and one reason adults may seek couples counseling. Within romantic relationships, adults individually experience sexual and affectionate desire, but also experience desire relative to their partner. If desire discrepancies exist, partners may attempt to resolve these discrepancies.

Mammal responses to global changes in human activity vary by trophic group and landscape.

Wildlife must adapt to human presence to survive in the Anthropocene, so it is critical to understand species responses to humans in different contexts. We used camera trapping as a lens to view mammal responses to changes in human activity during the COVID-19 pandemic. Across 163 species sampled in 102 projects around the world, changes in the amount and timing of animal activity varied widely.

Binary mixtures of imidacloprid and thiamethoxam do not appear to cause additive toxicity in fathead minnow larvae ().

Considerable use of neonicotinoid insecticides has resulted in their detection in surface waters globally, with imidacloprid (IM) and thiamethoxam (TM) frequently found together. Neonicotinoids are selective agonists for invertebrate nicotinic acetylcholine receptors (nAChR) leading to paralysis and death. While not overtly toxic to vertebrates, growing evidence suggests that chronic exposure to individual neonicotinoids can cause adverse health effects in fish.

Coming out autistic at work: A review of the literature.

Research consistently documents the poor postsecondary outcomes of autistic individuals. It is important to identify supports that help autistic individuals get and keep jobs to improve postsecondary outcomes. Autism diagnosis disclosure at work may serve as a support (e.

Teachers survive together: Teacher collegial relationships and well-being during the COVID-19 pandemic.

COVID-19 disrupted the ecology of schools and negatively influenced teacher mental health and retention. This mixed-methods study investigates the relationship between teacher well-being and teacher collegial relationships after a year enduring COVID-19 pandemic disruptions. By analyzing data collected through surveys ( = 185) and interviews ( = 27) with U.

Which information locations in covered entities under HIPAA must be secured first? A multi-criteria decision-making approach.

Creating adequate safeguards for physical and online locations (e.g., desktop computers, network servers) where protected health information (PHI) may be breached is critical for management within entities compliant with the Health Information Portability and Accountability Act (HIPAA).

NMR indicates the N-termini of PSGL1 and CCR7 bind competitively to the chemokine CCL21.

Chemokines are from a family of secreted cytokines that direct the trafficking of immune cells to coordinate immune responses. Chemokines are involved in numerous disease states, including responding to infections, autoimmune disorders, and cancer metastasis. Ther are chemokines, like CCL21, that signal for cellular migration through the activation of G protein-coupled receptors, like CCR7, through interaction with the receptor's extracellular N-terminus, loops, and core of the receptor.

An explanatory analytics framework for early detection of chronic risk factors in pandemics.

Timely decision-making in national and global health emergencies such as pandemics is critically important from various aspects. Especially, early identification of risk factors of contagious viral diseases can lead to efficient management of limited healthcare resources and saving lives by prioritizing at-risk patients. In this study, we propose a hybrid artificial intelligence (AI) framework to identify major chronic risk factors of novel, contagious diseases as early as possible at the time of pandemics.

A New Family of Layered Metal-Organic Semiconductors: Cu/V-Organophosphonates.

Herein, we report the design and synthesis of a layered redox-active, antiferromagnetic metal organic semiconductor crystals with the chemical formula [Cu(H O) V(µ-O)(PPA) ] (where PPA is phenylphosphonate). The crystal structure of [Cu(H O) V(µ-O)(PPA) ] shows that the metal phosphonate layers are separated by phenyl groups of the phenyl phosphonate linker. Tauc plotting of diffuse reflectance spectra indicates that [Cu(H O) V(µ-O)(PPA) ] has an indirect band gap of 2.

An Application of Inverse Reinforcement Learning to Estimate Interference in Drone Swarms.

Despite the increasing applications, demands, and capabilities of drones, in practice they have only limited autonomy for accomplishing complex missions, resulting in slow and vulnerable operations and difficulty adapting to dynamic environments. To lessen these weaknesses, we present a computational framework for deducing the original intent of drone swarms by monitoring their movements. We focus on interference, a phenomenon that is not initially anticipated by drones but results in complicated operations due to its significant impact on performance and its challenging nature.

Chronic Exposure to Environmentally Relevant Concentrations of Imidacloprid Impact Survival and Ecologically Relevant Behaviors of Fathead Minnow Larvae.

Imidacloprid (IM) has emerged as a contaminant of concern in several areas within the United States due to its frequent detection in aquatic ecosystems and its pseudo-persistence, which pose potential risks to nontarget species. We evaluated the sublethal toxicity of IM to fathead minnow larvae following chronic exposure beginning just after fertilization. Our in silico analysis and in vivo bioassays suggest that IM has a low binding affinity for the vertebrate nicotinate acetylcholine receptor (nAChR), as expected.

Attributions for abusive supervision: Who do subordinates blame and does it matter?

Drawing on attribution theory, we propose in Study 1 that subordinates' supervisor-directed responses to abusive supervision depend upon their causal attributions for the abuse. Using a scenario-based study (N = 183), we test a moderated mediation model in which the entity blamed for abusive supervision (supervisor, organization, self) is expected to predict subordinates' behavioral intentions toward their supervisor via affective responses (supervisor disliking). This relationship will be exacerbated when subordinates perceive the cause of abusive supervision as stable.

Predicting and Mitigating Freshmen Student Attrition: A Local-Explainable Machine Learning Framework.

With the emergence of novel methods for improving machine learning (ML) transparency, traditional decision-support-focused information systems seem to need an upgrade in their approach toward providing more actionable insights for practitioners. Particularly, given the complex decision-making process of humans, using insights obtained from group-level interpretation of ML models for designing individual interventions may lead to mixed results. The present study proposes a hybrid ML framework by integrating established predictive and explainable ML approaches for decision support systems involving the prediction of human decisions and designing individualized interventions accordingly.

A Bayesian belief network-based analytics methodology for early-stage risk detection of novel diseases.

During a pandemic, medical specialists have substantial challenges in discovering and validating new disease risk factors and designing effective treatment strategies. Traditionally, this approach entails several clinical studies and trials that might last several years, during which strict preventive measures are enforced to manage the outbreak and limit the death toll. Advanced data analytics technologies, on the other hand, could be utilized to monitor and expedite the procedure.