21 results match your criteria: "University of Western Sydney-School of Medicine[Affiliation]"
Neonatology
December 2024
Department of Newborn Care, Royal Hospital for Women, Randwick, New South Wales, Australia.
Introduction: Due to concerns of oxidative stress and injury, most clinicians currently use lower levels of fractional inspired oxygen (FiO2, 0.21-0.3) to initiate respiratory support for moderate to late preterm (MLPT, 32-36 weeks gestation) infants at birth.
View Article and Find Full Text PDFGenet Med
July 2023
Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Roberts Individualized Medical Genetics Center, The Children's Hospital of Philadelphia, Philadelphia, PA; Laboratory of Rare Disease Research, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan; Division of Genetics and Metabolism, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:
Purpose: This study aimed to establish variants in CBX1, encoding heterochromatin protein 1β (HP1β), as a cause of a novel syndromic neurodevelopmental disorder.
Methods: Patients with CBX1 variants were identified, and clinician researchers were connected using GeneMatcher and physician referrals. Clinical histories were collected from each patient.
Clin Genitourin Cancer
October 2022
Department of Medicine, University of New South Wales, Sydney, Australia.
Introduction: Selective internal radiation therapy (SIRT) is a potential treatment of primary renal cell carcinoma (RCC) deemed unsuitable for conventional therapy. RESIRT is the first-in-human study to evaluate safety and feasibility of SIRT for primary RCC.
Patients And Methods: Patients with RCC, unsuitable for, or who declined conventional therapy, were eligible.
Chronic Illn
September 2021
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Objectives: We report on the experiences of peer support facilitators and study nurses who participated in a large trial of peer support for type 2 diabetes. The support was led by volunteer peer support facilitators, who were trained in overcoming barriers to diabetes care, motivational interviewing, listening skills and setting up and running group support sessions. There is currently a distinct lack of qualitative evidence on what works in peer support.
View Article and Find Full Text PDFBMJ Open Diabetes Res Care
May 2016
Department of Rural Health, University of Melbourne, Shepparton, Victoria, Australia; University of Western Sydney School of Medicine, Campbelltown, New South Wales, Australia.
Objective: The significance of the metabolic syndrome (MS) is debated. We investigated whether MS component (by ATPIII and IDF definitions) clustering and any association between MS and prevalent cardiovascular disease (CVD) varied with age.
Research Design And Methods: In all, 1429 adults (≥25 years) from randomly selected households in rural Victoria, Australia, were assessed for components of MS and prevalent CVD.
Background: We interviewed graduates from the first two cohorts of a postgraduate medical program that had a senior year longitudinal integrated clerkship (LIC) in a practice setting in rural New South Wales, Australia to determine how well their training prepared them to be junior doctors (3-4 years after graduation), and what aspects of that training they thought were particularly useful.
Methods: In-depth interviews.
Results: Fourteen junior doctors were interviewed.
J Paediatr Child Health
January 2016
Department of Paediatrics, University of Western Sydney School of Medicine, Sydney, New South Wales, Australia.
Much of the repertoire of muscle function performed in everyday life involves isotonic dynamic movements, either with or without an additional load, yet most studies of single motor units measure isometric forces. To assess the effects of muscle load on the contractile response, we measured the contractile properties of single motor units supplying the toe extensors, assessed by intraneural microstimulation of single human motor axons, in isotonic, loaded isotonic, and isometric conditions. Tungsten microelectrodes were inserted into the common peroneal nerve, and single motor axons (n = 10) supplying the long toe extensors were electrically stimulated through the microelectrode.
View Article and Find Full Text PDFEur Urol
October 2015
Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.
Background: Metastatic castration-resistant prostate cancer (mCRPC) often involves bone, and bone-targeted therapy (BTT) has become part of the overall treatment strategy.
Objective: Investigation of outcomes for concomitant BTT in a post hoc analysis of the COU-AA-302 trial, which demonstrated an overall clinical benefit of abiraterone acetate (AA) plus prednisone over placebo plus prednisone in asymptomatic or mildly symptomatic chemotherapy-naïve mCRPC patients.
Design, Setting, And Participants: This report describes the third interim analysis (prespecified at 55% overall survival [OS] events) for the COU-AA-302 trial.
J Clin Oncol
April 2015
Michael J. Morris, Steven M. Larson, and Howard I. Scher, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY; Arturo Molina, Thian Kheoh, Shannon L. Matheny, Vahid Naini, and Thomas W. Griffin, Janssen Research & Development, Los Angeles; Eric J. Small and Charles J. Ryan, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA; Johann S. de Bono, Institute for Cancer Research and Royal Marsden Hospital, Sutton, United Kingdom; Christopher J. Logothetis, MD Anderson Cancer Center, Houston, TX; Karim Fizazi, Institut Gustave Roussy, University of Paris Sud, Villejuif, France; Paul de Souza, University of Western Sydney School of Medicine, Ingham Institute, Liverpool, New South Wales, Australia; Philip W. Kantoff, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Celestia S. Higano, University of Washington, Seattle, WA; Jinhui Li, Janssen Research & Development, Raritan, NJ; and Tomasz Burzykowski, International Drug Development Institute, Louvain-la-Neuve, Belgium.
Purpose: Progression-free survival (PFS) in metastatic castration-resistant prostate cancer (mCRPC) trials has been inconsistently defined and poorly associated with overall survival (OS). A reproducible quantitative definition of radiographic PFS (rPFS) was tested for association with a coprimary end point of OS in a randomized trial of abiraterone in patients with mCRPC.
Patients And Methods: rPFS was defined as ≥ two new lesions on an 8-week bone scan plus two additional lesions on a confirmatory scan, ≥ two new confirmed lesions on any scan ≥ 12 weeks after random assignment, and/or progression in nodes or viscera on cross-sectional imaging, or death.
Lancet Oncol
February 2015
Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Background: Abiraterone acetate plus prednisone significantly improved radiographic progression-free survival compared with placebo plus prednisone in men with chemotherapy-naive castration-resistant prostate cancer at the interim analyses of the COU-AA-302 trial. Here, we present the prespecified final analysis of the trial, assessing the effect of abiraterone acetate plus prednisone on overall survival, time to opiate use, and use of other subsequent therapies.
Methods: In this placebo-controlled, double-blind, randomised phase 3 study, 1088 asymptomatic or mildly symptomatic patients with chemotherapy-naive prostate cancer stratified by Eastern Cooperative Oncology performance status (0 vs 1) were randomly assigned with a permuted block allocation scheme via a web response system in a 1:1 ratio to receive either abiraterone acetate (1000 mg once daily) plus prednisone (5 mg twice daily; abiraterone acetate group) or placebo plus prednisone (placebo group).
BJU Int
June 2015
ANZUP Cancer Trials Group, Sydney, NSW, Australia.
Eur Urol
November 2014
CRCHUM, University of Montréal, Montréal, Québec, Canada.
Background: Abiraterone acetate (an androgen biosynthesis inhibitor) plus prednisone is approved for treating patients with metastatic castration-resistant prostate cancer (mCRPC). Study COU-AA-302 evaluated abiraterone acetate plus prednisone versus prednisone alone in mildly symptomatic or asymptomatic patients with progressive mCRPC without prior chemotherapy.
Objective: Report the prespecified third interim analysis (IA) of efficacy and safety outcomes in study COU-AA-302.
: A five-year-old year old girl developed fever of 40.3° C, vomiting, mild general abdominal pain, followed by bloody diarrhea. : Ultrasonography revealed a length of symmetrically thickened terminal ileum, more than 20 cm long, with walls greater than 0.
View Article and Find Full Text PDFTeach Learn Med
June 2014
a Medical Education , University of Western Sydney School of Medicine, Campbelltown , Australia.
Background: Professional identity, or how a doctor thinks of himself or herself as a doctor, is considered to be as critical to medical education as the acquisition of skills and knowledge relevant to patient care.
Summary: This article examines contemporary literature on the development of professional identity within medicine. Relevant theories of identity construction are explored and their application to medical education and pedagogical approaches to enhancing students' professional identity are proposed.
Korean J Pathol
February 2013
Discipline of Pathology, University of Western Sydney School of Medicine, Liverpool, NSW, Australia. ; Cancer Pathology and Cell Biology Laboratory, Ingham Institute of Applied Medical Research, Liverpool, NSW, Australia. ; Department of Anatomical Pathology, Liverpool Hospital, Sydney South West Area Pathology Service, Liverpool, NSW, Australia.
Preoperative radiotherapy may improve the resectability and subsequent local control of rectal cancers. However, the extent of radiation induced regression in these tumours varies widely between individuals. To date no reliable predictive marker of radiation sensitivity in rectal cancer has been identified.
View Article and Find Full Text PDFBMC Fam Pract
January 2013
University of Western Sydney-School of Medicine, Campbelltown, NSW 2560, Australia.
Background: In a General Practitioner (GP) setting, preventative medicine is reported as the predominant source of health care for the well-child. However, the role of the GP in well-child health care is not well understood in Australia. The aim of this study was to describe the role of the GP in providing services for well-children and families in Australia.
View Article and Find Full Text PDFTransl Androl Urol
December 2012
1 Department of Medical Oncology, Liverpool Hospital, NSW, Australia ; 2 University of Western Sydney School of Medicine CRG, NSW, Australia.
Ann Oncol
September 2012
Department of Oncology, GlaxoSmithKline Research and Development, Research Triangle Park, Philadelphia, United States.
Immunotherapy
May 2012
Cancer Pathology & Cell Biology Laboratory, Ingham Institute of Applied Medical Research, & Discipline of Pathology, University of Western Sydney School of Medicine, Liverpool 2170, Australia.
Aim: To investigate orthotopic targeted α-radioimmunotherapy for the control of early-stage PC3 prostate cancer nude mouse xenografts using the radiolabeled bevacizumab (BZ) immunoconjugate ((213)Bi-BZ), which emits short-range α-radiation.
Materials & Methods: 10(6) PC3 human prostate cancer cells were injected into the lower capsule of the mouse prostate gland 1 week prior to α-radioimmunotherapy. Mice were euthanized and assessed for tumour growth at 2 (two mice), 4 (two mice) and 6 weeks (three mice) post-therapy.
Nephrology (Carlton)
February 2011
Department of Medicine, University of Western Sydney School of Medicine, New South Wales, Australia.
With the recent discovery of potential serum 'toxins' in human preeclampsia, it is timely to consider how these might relate to preeclamptic nephropathy. This review will discuss the clinical presentation of preeclampsia with an emphasis on renal involvement. It will explore the nature of the renal histological changes including endothelial and the more recently discovered podocyte changes, the implications of elevated anti-angiogenic molecules, anti-angiotensin-1 receptor agonistic antibodies and other proposed mechanisms in causing or exacerbating renal lesions.
View Article and Find Full Text PDF