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29,764 results match your criteria: "University of Western Ontario.[Affiliation]"
Front Hum Neurosci
December 2024
Department of Psychology and Institute of Neuroscience, University of Nevada, Reno, NV, United States.
The neural underpinnings of working memory (WM) have been of continuous scientific interest for decades. As the understanding of WM progresses and new theories, such as the distributed view of WM, develop, the need to advance the methods used to study WM also arises. This perspective discusses how building from the state-of-the-art in the field of transcranial magnetic stimulation (TMS), and utilising cortico-cortical TMS, may pave the way for testing some of the predictions proposed by the distributed WM view.
View Article and Find Full Text PDFJ Bone Joint Surg Am
December 2024
Division of Orthopedic Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada.
➢ Low back pain has a lifetime incidence of up to 84% and represents the leading cause of disability in the United States; 10% to 38% of cases can be attributed to sacroiliac joint (SIJ) dysfunction as an important pain generator.➢ Physical examination of the SIJ, including >1 provocation test (due to their moderate sensitivity and specificity) and examination of adjacent joints (hip and lumbar spine) should be routinely performed in all patients presenting with low back, gluteal, and posterior hip pain.➢ Radiographic investigations including radiographs, computed tomography, and magnetic resonance imaging with protocols optimized for the visualization of the SIJs may facilitate the diagnosis of common pathologies.
View Article and Find Full Text PDFJ Geriatr Phys Ther
December 2024
Roth McFarlane Hand and Upper Limb Center, St. Joseph's Health Centre, University of Western Ontario, London, Ontario, Canada.
Background And Purpose: Fear of falling (FoF) is a persistent anxiety regarding the risk of falling, which can even impact individuals without a history of falls. Fear of falling has been associated with decreased physical functioning and increased risk of falls. Most interventions have focused on reducing FoF in healthy older adults.
View Article and Find Full Text PDFQual Life Res
December 2024
School of Physical Therapy, University of Western Ontario, London, Canada.
Introduction: Patient Reported Outcome Measures (PROMs) are used widely to collect patient perspectives on their Health-Related Quality of Life (HRQoL) after stroke. Existing reviews on PROMs typically report the psychometric properties but rarely focus on the content validity. We performed a structured review of the content of items of stroke-specific HRQoL outcomes.
View Article and Find Full Text PDFAdv Mater
December 2024
Department of Mechanical & Industrial Engineering (MIE), University of Toronto, Toronto, Ontario, M5S 3G8, Canada.
MXene has garnered growing interest in the field of electrochemistry, thanks to its unique electrical and surface characteristics. Nonetheless, significant challenges persist in realizing its full potential in chemoresistive sensing applications. In this study, a novel unidirectional freeze-casting approach for fabricating a Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS)-facilitated vertically aligned MXene-based aerogel with enhanced chemoresistive sensing properties was introduced.
View Article and Find Full Text PDFActa Neuropathol Commun
December 2024
Department of Pharmacology & Therapeutics, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler Room 1210, Montreal, H3G 1Y6, Canada.
The combination of amyloid beta and tau pathologies leads to tau-mediated neurodegeneration in Alzheimer's disease. However, the relative contributions of amyloid beta and tau peptide accumulation to the manifestation of the pathological phenotype in the early stages, before the overt deposition of plaques and tangles, are still unclear. We investigated the longitudinal pathological effects of combining human-like amyloidosis and tauopathy in a novel transgenic rat model, coded McGill-R-APPxhTau.
View Article and Find Full Text PDFJ Comp Physiol A Neuroethol Sens Neural Behav Physiol
December 2024
WasserCluster Lunz - Biologische Station GmbH, Dr. Carl Kupelwieser Promenade 5, Lunz am See, A-3293, Austria.
Monarch butterflies (Danaus plexippus) undertake one of the most remarkable long-distance insect migrations, travelling thousands of kilometres to overwinter in the central trans-volcanic belt of Mexico. This study explored how monarch butterflies use essential fatty acids (EFA) and nonessential fatty acids (NFA) during overwintering. We collected 150 (male/female) butterflies from the Sierra Chincua wintering colony from the time of arrival (December 2022) to before departure (February 2023) and analysed their lipid content.
View Article and Find Full Text PDFLancet Neurol
January 2025
Departments of Internal Medicine, Microbiology & Immunology, Western Institute of Neuroscience, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5K8, Canada. Electronic address:
Anal Chem
December 2024
Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada.
Reversed-phase liquid chromatography (RPLC) is an essential tool for separating complex mixtures such as proteolytic digests in bottom-up proteomics. There is growing interest in methods that can predict the RPLC retention behavior of peptides and other analytes. Already, existing algorithms provide excellent performance based on empirical rules or large sets of RPLC training data.
View Article and Find Full Text PDFEpilepsia
December 2024
Department of Neurosurgery, Emory University, Atlanta, Georgia, USA.
Objective: Stereotactic laser amygdalohippocampotomy (SLAH) is a minimally invasive procedure for mesial temporal lobe epilepsy that preserves more tissue than open procedures. As a result, although patients have better functional outcomes, more patients do not achieve seizure freedom. The rate at which this occurs is evolving with improved surgical practices.
View Article and Find Full Text PDFCommun Biol
December 2024
Robarts Research Institute, University of Western Ontario, London, ON, N6A 5B7, Canada.
The Pro/N-degron recognizing C-terminal to LisH (CTLH) complex is an E3 ligase of emerging interest in the developmental biology field and for targeted protein degradation (TPD) modalities. The human CTLH complex forms distinct supramolecular ring-shaped structures dependent on the multimerization of WDR26 or muskelin β-propeller proteins. Here, we find that, in HeLa cells, CTLH complex E3 ligase activity is dictated by an interplay between WDR26 and muskelin in tandem with muskelin autoregulation.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Department of Chemical and Biochemical Engineering, University of Western Ontario, London, ON N6A 5B9, Canada. Electronic address:
In modern times, achieving precise drug delivery through a safe and stable carrier remains a significant challenge. In this study, we synthesized a novel ligand based on a guanazole Schiff base and subsequently developed new metal-organic framework (MOF) named UWO-1 through a reaction involving zinc acetate. At the same time, curcumin (CUR) was loaded onto the newly synthesized UWO-1.
View Article and Find Full Text PDFPublic Health
December 2024
Institute of Health Policy, Management and Evaluation, University of Toronto, 155 College Street, Suite 425, Toronto, ON, M5T 3M6, Canada; SRA Academy Inc., 110 Sheppard Ave E., Suite 615, North York, ON, M2N 6Y8, Canada. Electronic address:
Objectives: The adoption of artificial intelligence (AI) in healthcare is rapidly expanding, transforming areas such as diagnostics, drug discovery, and patient monitoring. Despite these advances, public perceptions of AI in healthcare, particularly in Canada, remain underexplored. This study investigates the relationship between Canadians' knowledge, comfort, and trust in AI, focusing on key sociodemographic factors like age, gender, education, and income.
View Article and Find Full Text PDFBr J Radiol
December 2024
Princess Margaret Cancer Centre, University Health Network, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Introduction: Recent advances in image-guided brachytherapy have allowed for treatment volume reduction in the treatment of prostate cancer, with the aim to optimize disease control and reduce toxicities. This systematic review reports on the efficacy and safety of focal brachytherapy for treatment of patients with localized prostate cancer.
Methods: Medline, Embase, Web of Science and Cochrane were searched from inception to July 2023.
Langmuir
December 2024
Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada.
Black phosphorus quantum dots (BPQDs) have shown promising applications in biosensors and energy storage devices. However, the electrochemiluminescence (ECL) properties of pristine BPQDs in an organic system have rarely been reported. In this paper, ,'-dimethylformamide passivated BPQDs with a small size of 2.
View Article and Find Full Text PDFJ Dent Res
December 2024
Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, Canada.
Recent years have seen significant positive changes and developments in oral health-related policy and data on oral health and oral health care in Canada. Simultaneously, on the international stage, the momentum for oral health and related research continues to build. These changes have led to an initiative to create Canada's first National Oral Health Research Strategy (NOHRS), which was recently published by the Canadian Institutes of Health Research-Institute of Musculoskeletal Health and Arthritis (Allison and Rock 2024).
View Article and Find Full Text PDFCurr Issues Personal Psychol
October 2024
University of Western Ontario, London, ON, Canada.
Background: Machiavellianism and social dominance orientation are two constructs associated with socially undesirable behavior and predictors of prejudice; however, their relationship has mainly been investigated through measures that only assess the antagonism dimension of Machiavellianism. Thus, this study aimed to disentangle their relationship using an instrument assessing agency and planfulness.
Participants And Procedure: Participants were 767 Brazilians aged 18 to 71 ( = 30.
J Phys Chem A
December 2024
Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada.
BMC Genomics
December 2024
School of Computer Science, University of Waterloo, Waterloo, Canada.
Background: Traditional supervised learning methods applied to DNA sequence taxonomic classification rely on the labor-intensive and time-consuming step of labelling the primary DNA sequences. Additionally, standard DNA classification/clustering methods involve time-intensive multiple sequence alignments, which impacts their applicability to large genomic datasets or distantly related organisms. These limitations indicate a need for robust, efficient, and scalable unsupervised DNA sequence clustering methods that do not depend on sequence labels or alignment.
View Article and Find Full Text PDFBMC Cancer
December 2024
Laboratory of Neurobiology and Stem Cells, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
Background: Glioblastoma (GBM) is an aggressive brain tumor driven by glioblastoma stem cells (GSCs), which represent an appealing target for therapeutic interventions. The cellular prion protein (PrP), a scaffold protein involved in diverse cellular processes, interacts with various membrane and extracellular matrix molecules, influencing tumor biology. Herein, we investigate the impact of PrP expression on GBM.
View Article and Find Full Text PDFHuman treponemal infections are caused by a family of closely related Treponema pallidum that give rise to the diseases yaws, bejel, pinta and, most famously, syphilis. Debates on both a common origin for these pathogens and the history of syphilis itself has weighed evidence for the "Columbian hypothesis", which argues for an American origin, against that for the "pre-Columbian hypothesis", which argues for presence of the disease in Eurasia in the Medieval period and possibly earlier. While molecular data has provided a genetic basis for distinction of the typed subspecies, deep evolution of the complex has remained unresolved due to limitations in the conclusions that can be drawn from the sparse paleogenomic data currently available.
View Article and Find Full Text PDFArthritis Rheumatol
December 2024
Bone and Joint Institute, University of Western Ontario, London Health Sciences Centre-University Hospital, London, ON, Canada, N6A 5B5.
Objective: Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate immune cell infiltration (synovitis), but the role of innate immune regulatory cells in pain is unknown. Our objective was to identify synovial innate immune cell subsets and pathophysiologic mechanisms associated with worse pain in patients with knee OA.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
December 2024
University of Western Ontario: Western University, Chemistry, CANADA.
The development of polymers from renewable resources is a promising approach to reduce reliance on petrochemicals. In addition, depolymerization is attracting significant attention for the breakdown of polymers at their end-of-life or to achieve specific stimuli-responsive functions. However, the design of polymers incorporating both of these features remains a challenge.
View Article and Find Full Text PDFRadiol Case Rep
February 2025
Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Creutzfeldt-Jakob Disease (CJD) is a rare, fatal neurodegenerative disorder that is caused by prion proteins. Patients often present with rapidly progressive dementia, ataxia, myoclonus, memory impairment, visual problems, and changes in personality. In this case report, we aimed to address the course of a 62 year old female who presented with progressive decline in cognitive function and died within 6 months of presentation.
View Article and Find Full Text PDFCancers (Basel)
November 2024
Precision Diagnostics and Therapeutics Program, Division of Anatomic Pathology, Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.
Background: Targeted next-generation sequencing (NGS) panels are increasingly being utilized to identify actionable gene amplifications (copy number > 4) among solid tumors.
Methods: This study validated the analytical performance of two amplicon-based NGS assays, the Oncomine Comprehensive Panel (OCAv3) and the Oncomine Focus Assay (OFA), for detecting gene amplification in formalin-fixed paraffin-embedded (FFPE) tumors of varying cellularity. OCAv3 was assessed for amplification detection in 756 FFPE samples comprising various tumor types.