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Endometrial Synovial-like Metaplasia Associated With Levonorgestrel-releasing Intrauterine System.
Int J Gynecol Pathol
November 2015
Department of Histopathology (C.J.R.S.), King Edward Memorial Hospital, Subiaco School for Women's and Infants' Health (C.J.R.S.), University of Western Australia Hollywood Hospital (R.L.), Nedlands, Perth, WA, Australia.
The levonorgestrel-releasing intrauterine system (L-IUS) is widely used in contraception and in the treatment of menorrhagia, dysmenorrhea, adenomyosis, and endometriosis. L-IUS is also increasingly considered in the management of endometrial neoplasia and its precursors. Histologic changes in the endometrium can be due to the effects of high-dose progestogen or may be caused by the local irritant or mechanical effects of an intrauterine foreign body.
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