ANZACS-QI Heart Failure Registry: a new approach using age-stratified sampling of hospital discharges to guide quality improvement (ANZACS-QI 79).

Heart failure is a major healthcare problem in New Zealand. The Acute Decompensated Heart Failure (ADHF) Registry was introduced in 2015, and has identified the need for quality improvement strategies to improve care of patients hospitalised with heart failure. In this paper, we describe the implementation of the revised ANZACS-QI Heart Failure Registry, which has a primary aim to support evidence-based management of and quality improvement measures for patients who are hospitalised with heart failure in New Zealand.

Addressing closed and limited enrolments in general practices in Aotearoa New Zealand: a mixed-methods study.

Aim: To ascertain the reasons for and impacts of closed books in general practices in Aotearoa New Zealand and report recommendations for mitigation.

Method: A mixed-methods approach was used. A first round of interviews with experts in the primary care sector was conducted, followed by a survey across general practices and, finally, a second round of interviews.

Sensitivity Analysis of One-Dimensional Multiphysics Simulation of CO Electrolysis Cell.

Electrochemical (EC) carbon dioxide (CO) reduction, where CO is converted to value-added products such as fuel precursors, plays a key role in helping the world's energy system reach net-zero carbon emissions. Simulations of EC cells provide valuable insight into their operation since detailed experimental results on short length and time scales are difficult to obtain. In this work, we construct a 1D simulation of a membrane-electrode-assembly EC cell for CO reduction, using a porous silver gas diffusion cathode.

Co(III) complexes of the pentadentate NHC ligand PY4Im: carbene-induced influences and the non-disappearing C NMR peak.

Co(III) complexes of the N-heterocyclic carbene ligand PY4Im (PY4Im = (1,3-bis(bis(2-pyridyl)methyl)imidazol-2-ylidene)) having the general formula [(PY4Im)Co(X)](ClO) (X = NCMe; = 3: OH, N, NCS, ONO, F; = 2: OCO, = 1; (N), = 0) were prepared and structurally characterised. X-ray structural data are consistent with the presence of a influence due to the coordinated carbene carbon, and this is also supported by computational results. C NMR spectra of the complexes did not display peaks corresponding to the carbene carbon, except in the case of the [(PY4Im)Co(OCO)] cation, where a peak at = 170.

A large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration.

Many genes are known to regulate retinal regeneration after widespread tissue damage. Conversely, genes controlling regeneration after limited cell loss, as per degenerative diseases, are undefined. As stem/progenitor cell responses scale to injury levels, understanding how the extent and specificity of cell loss impact regenerative processes is important.

Synthesis and glycosidase inhibition of 3,4,5-trihydroxypiperidines using a one-pot amination-cyclisation cascade reaction.

Trihydroxypiperidines are a therapeutically valuable class of iminosugar. We applied a one-pot amination-cyclisation cascade reaction to synthesise 3,4,5-trihydroxypiperidine stereoisomers in three steps from commercially available pentoses and in excellent overall yields. Using our methodology, the yields of the syntheses of meso-1, meso-2 and 3L are the highest reported to date.

Proteomes of native and non-native symbionts reveal responses underpinning host-symbiont specificity in the cnidarian-dinoflagellate symbiosis.

Cellular mechanisms responsible for the regulation of nutrient exchange, immune responses, and symbiont population growth in the cnidarian-dinoflagellate symbiosis are poorly resolved, particularly with respect to the dinoflagellate symbiont. Here, we characterized proteomic changes in the native symbiont Breviolum minutum during colonization of its host sea anemone Exaiptasia diaphana ("Aiptasia"). We also compared the proteome of this native symbiont in the established symbiotic state with that of a non-native symbiont, Durusdinium trenchii.

Transgender, Gender-Diverse, and Nonbinary Experiences in Physical Therapy: A Descriptive Qualitative Study.

Objective: The objective was to explore experiences with and identify barriers and facilitators of utilizing physical therapy for people who identify as transgender, gender diverse, and nonbinary (TGNB).

Methods: A qualitative descriptive design was employed using semistructured interviews conducted in New Zealand. Eligible participants were individuals who were 12 years old or older, who self-identified as TGNB, and who had accessed physical therapy at a community-based clinic that also provides a gender-affirming service.

High economic inequality is linked to greater moralization.

Throughout the 21st century, economic inequality is predicted to increase as we face new challenges, from changes in the technological landscape to the growing climate crisis. It is crucial we understand how these changes in inequality may affect how people think and behave. We propose that economic inequality threatens the social fabric of society, in turn increasing moralization-that is, the greater tendency to employ or emphasize morality in everyday life-as an attempt to restore order and control.

Site-Selective Photobromination of -Acetylated Carbohydrates in Benzotrifluoride.

Ferrier photobromination enables direct synthetic access to valuable 5--bromosugars but has limitations that restrict its broader use. The reaction is typically conducted in CCl heated at reflux with irradiation by broad spectrum, energy-inefficient heat lamps. Herein, we demonstrate that the reaction proceeds rapidly and efficiently with PhCF as a safe and environmentally benign alternative to CCl at mild temperatures (≤40 °C) inside a compact photoreactor fitted with purple light-emitting diodes (LEDs).

Anti-inflammatory decurrencyclics A-B, two undescribed nor-dammarane triterpenes from triangular sea bell .

Significant concerns are raised regarding the legitimacy of the spectroscopic data provided in the titled manuscript. Many of the spectra provided in the supplemental material file show signs of being purposefully manipulated. Readers of the manuscript should treat the conclusions drawn, including the structures proposed, with extreme caution.

Dying well in Aotearoa New Zealand for ethnic minority communities: a time for reclamation?

Despite technological advances and a disproportionate increase in health expenditure at the end-of-life, most New Zealanders die in hospital or in aged residential care. This counters the aspirations espoused by Te Whatu Ora (Health New Zealand) for all New Zealanders "to live well, age well and die well in their homes and communities." Furthermore, despite reported inequities in end-of-life care experienced by ethnic minority communities (EMCs) overseas, and increasing proportions of people identifying with Asian, Middle Eastern, Latin American and African ethnicities in Aotearoa New Zealand, local data, research and policies addressing healthcare needs of EMCs at end-of-life are scant.

Parents' experiences of family and daily life after their child's stay in the pediatric intensive care unit: a qualitative descriptive study.

Introduction: The stay of a critically ill child in a pediatric intensive care unit (PICU) is a significant experience for the family. Thus far, little is known regarding the impact of this stay on parents and their healthy children for whom no continuous aftercare services are offered. This study aimed to capture the post-stay experience and needs of parents after this traumatic event so that they could return to family and everyday life.

Implementing new forms of collaboration and participation in primary health care: leveraging past learnings to inform future initiatives.

Introduction Within primary health care policy, there is an increasing focus on enhancing involvement with secondary health care, social care services and communities. Yet, translating these expectations into tangible changes frequently encounters significant obstacles. As part of an investigation into the progress made in achieving primary health care reform in Aotearoa New Zealand, realist research was undertaken with those charged with responsibility for national and local policies.

Unmet need for primary health care and subsequent inpatient hospitalisation in Aotearoa New Zealand. A cohort study.

Introduction The inability to afford a consultation with a general practitioner may lead to delays in accessing care pathways. Aim This study aimed to explore the characteristics of people by their unmet need for a general practitioner consultation because of cost, and the characteristics of subsequent inpatient hospitalisations. Methods From the New Zealand Health Surveys (2013/14-2018/19), two groups were formed based on their unmet need for a general practitioner consultation due to cost.

How is enrolment with a general practice associated with subsequent use of the emergency department in Aotearoa New Zealand? A cohort study.

Introduction Around 5% of the people in Aotearoa New Zealand (NZ) are not enrolled with a general practice. Aim This study aimed to explore the utilisation of general practice by enrolment status and subsequent use of an emergency department. Methods We compared a cohort of respondents from New Zealand Health Surveys (2013/14-2018/19) on self-reported general practice utilisation and their substitutes, according to their enrolment status (enrolled and not enrolled).

Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623.

Bacterial nitroreductase enzymes capable of activating imaging probes and prodrugs are valuable tools for gene-directed enzyme prodrug therapies and targeted cell ablation models. We recently engineered a nitroreductase ( NfsB F70A/F108Y) for the substantially enhanced reduction of the 5-nitroimidazole PET-capable probe, SN33623, which permits the theranostic imaging of vectors labeled with oxygen-insensitive bacterial nitroreductases. This mutant enzyme also shows improved activation of the DNA-alkylation prodrugs CB1954 and metronidazole.

Characterizing Complex Spatiotemporal Patterns from Entropy Measures.

In addition to their importance in statistical thermodynamics, probabilistic entropy measurements are crucial for understanding and analyzing complex systems, with diverse applications in time series and one-dimensional profiles. However, extending these methods to two- and three-dimensional data still requires further development. In this study, we present a new method for classifying spatiotemporal processes based on entropy measurements.

The Impact of Partial Carrier Confinement on Stimulated Emission in Strongly Confined Perovskite Nanocrystals.

Semiconductor lead halide perovskites are excellent candidates for realizing low threshold light amplification due to their tunable and highly efficient luminescence, ease of processing, and strong light-matter interactions. However, most studies on optical gain have addressed bulk films, nanowires, or nanocrystals that exhibit little or no size quantization. Here, we show by means of a multitude of optical spectroscopy methods that small CsPbBr nanocrystals (NCs) exhibit a progressive red shift of the band-edge transition upon addition of electron-hole pairs, at least one carrier of which occupies a 2-fold degenerate, delocalized state in agreement with strong confinement.

Resolving decades of debate: the surprising role of high-temperature covalency in the structure of liquid gallium.

Liquid metals (LMs) have the potential to revolutionise many important technologies, ranging from battery components to catalytic reactions. Low melting temperature gallium (Ga) is particularly promising as a solvent in many LM alloys, due to the low energy cost of maintaining its liquid state. However, despite 30+ years of study on the nature of Ga's liquid structure, it remains enigmatic with significant disagreement among the many published reports.

Mixing and matching ,- and ,-chelates in anionic Mg(I) compounds: synthesis and reactivity with RNCNR and CO.

Reduction of [Mg(NON)] ([NON] = [O(SiMeNDipp)], Dipp = 2,6-iPrCH) affords Mg(I) species containing NON- and NNO-ligands ([NNO] = [N(Dipp)SiMeN(Dipp)SiMeO]). The products of reactions with iPrNCNiPr and CO are consistent with the presence of reducing Mg(I) centres. Extraction with THF affords [K(THF)][(NNO)Mg-Mg(NNO)] with a structurally characterised Mg-Mg bond that was examined using density functional theory.

Inequities in adolescent sleep health in Aotearoa New Zealand: Cross-sectional survey findings.

Objectives: To investigate ethnic inequities in, and social determinants of, adolescent sleep health in Aotearoa New Zealand.

Methods: Analysis of self-report data from a cross-sectional survey of secondary school students (12- to 18-year-olds). Analyses included weighted prevalence estimates of good and poor sleep health stratified by ethnicity, and multivariable logistic regression models concurrently adjusted for ethnicity, school year, gender, rurality, neighborhood deprivation, school decile, housing deprivation, sleeping elsewhere due to lack of adequate housing, unsafe environment, and racism.

Author Correction: The immune response to RNA suppresses nucleic acid synthesis by limiting ribose 5-phosphate.

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