Epigenetic Regulation of ABA-Induced Transcriptional Responses in Maize.

Plants are subjected to extreme environmental conditions and must adapt rapidly. The phytohormone abscisic acid (ABA) accumulates during abiotic stress, signaling transcriptional changes that trigger physiological responses. Epigenetic modifications often facilitate transcription, particularly at genes exhibiting temporal, tissue-specific and environmentally-induced expression.

A cross-sectional study of social inequities in medical crowdfunding campaigns in the United States.

Americans are increasingly relying on crowdfunding to pay for the costs of healthcare. In medical crowdfunding (MCF), online platforms allow individuals to appeal to social networks to request donations for health and medical needs. Users are often told that success depends on how they organize and share their campaigns to increase social network engagement.

Lipophilic Antioxidants and Cognitive Function in the Elderly.

Objective: To determine the relationship between blood serum lipophilic antioxidant levels and cognitive function (CF) in older adults aged 60 and above guided by the oxidative stress theory of aging.

Methods: Cross-sectional data from the National Health and Nutrition Examination Survey ( = 291) for older adults aged 60 and above were examined using Pearson correlation coefficient and multiple linear regression to determine whether blood serum antioxidant status predicted CF while controlling for age, sex, race, hypertension, smoking status, and body mass index.

Results: Alpha-tocopherol, retinyl palmitate, trans-lycopene, and retinyl stearate were all significantly correlated with CF.

Is memorization the name of the game? Undergraduates' perceptions of the usefulness of physiology songs.

The possible benefits of using music to enhance learning of STEM content are numerous, diverse, and largely unproven. We sought to determine which (if any) of these possible benefits are commonly experienced by undergraduate students and are thus especially worthy of further investigation. Four hundred ninety-three students in nine physiology courses at two midsized American universities rated the usefulness of short instructor-penned mathematical physiology songs and explained in their own words why each song would or would not be a useful study aid.

Cytochrome ' Is a Variant in the P460 Superfamily Lacking the Heme-Lysyl Cross-Link: A Peroxidase Mimic Generating a Ferryl Intermediate.

A defining characteristic of bacterial cytochromes (cyt's) in the P460 family is an unusual cross-link connecting the heme porphyrin to the side chain of a lysyl residue in the protein backbone. Here, via proteomics of the periplasmic fraction of the ammonia-oxidizing bacterium (AOB) , we report the identification of a variant member of the P460 family that contains a methionyl residue in place of the cross-linking lysine. We formally designate this protein cytochrome "'" to distinguish it from other members bearing different residues at this position (e.

Molecular Dynamics Simulations of the Hypoxia-Inducible Factor PAS-B Domain Confirm That Internally Bound Water Molecules Function To Stabilize the Protein Core for Ligand Binding.

Hypoxia-inducible factors (HIFs) are heterodimeric transcription factors that are induced in many cancer types, promoting tumor-forming pathways. The HIF-2α PAS-B domain of the human HIF-2 complex contains a large buried hydrophilic cavity that is filled with eight ordered water molecules, making the domain a promising drug target. Recent work has led to the hypothesis that these buried water molecules act as an internal scaffold that stabilizes the buried cavity, holding it open to ease ligand binding.

Outrage and the emotional labour associated with environmental activism among nurses.

Aim: To investigate the emotions associated with environmental activism among nurses.

Background: Nursing has a long history of political activism in relation to social justice issues. Some nurses are environmental activists.

Optimizing college health promotion in the digital age: Comparing perceived well-being, and health behaviors, health education needs and preferences between college students enrolled in fully online versus campus-based programss.

There is little published about non-traditional and online college students' health and well-being. College health services must evolve to address the needs of this growing population. The purpose of this study was to explore risk factors, perceived well-being, health behaviors, and health education preferences of US college students enrolled in a fully online academic programs compared to a national sample of college students enrolled in campus based programs.

Gender-Transformative Approaches to Engaging Men in Reducing Gender-Based Violence: A Response to Brush & Miller's "Trouble in Paradigm".

Brush and Miller's paper is critical of gender-transformative interventions and they believe that the paradigm is in trouble. In this response, we examine the body of evidence and the conceptual frames that undergird gender-transformative interventions, along with the emergence of these interventions and their efficacy. We argue here that it is reductionist to state either (a) that gender-transformative programs do not work, or (b) that gender-transformative programs only rely on social norms theory.

Relationships between Particulate Matter, Ozone, and Nitrogen Oxides during Urban Smoke Events in the Western US.

Urban ozone (O) pollution is influenced by the transport of wildfire smoke but observed impacts are highly variable. We investigate O impacts from smoke in 18 western US cities during July-September, 2013-2017, with ground-based monitoring data from air quality system sites, using satellite-based hazard mapping system (HMS) fire and smoke product to identify overhead smoke. We present four key findings.

Concordance as a Person-Centered Measure of Breastfeeding Success: From Adequacy to Agency.

Health benefits associated with breastfeeding are supported by extensive research. Measurements of breastfeeding success in clinical and research settings have focused on maximizing adherence to population-level health recommendations for infant feeding (compliance). Concordance, a new adjunct measure of breastfeeding success, uses a comparison between the parent's intended feeding method and the actual feeding method to better assess whether the person's goals for infant feeding have been met.

On the CUSP: the politics and prospects of scaling social norms change programming.

In the past decades, donors and development actors have been increasingly mindful of the evidence to support long-term, dynamic social norms change. This paper draws lessons and implications on scaling social norms change initiatives for gender equality to prevent violence against women and girls (VAWG) and improve sexual and reproductive health and rights (SRHR), from the Community for Understanding Scale Up (CUSP). CUSP is a group of nine organisations working across four regions with robust experience in developing evidence-based social norms change methodologies and supporting their scale-up across various regions and contexts.

Internalized HIV-Related Stigma and Breast Health Beliefs Among African-American Women Receiving Care for HIV in the USA.

Objectives: African-American women suffer disproportionately from HIV, breast cancer, and other illnesses. Little is known about the relationship between internalized HIV-related stigma and health beliefs related to other illnesses, including breast cancer. Our study examined (1) the relationship between internalized HIV-related stigma and breast health beliefs over time and (2) the moderating effects of participating in a stigma reduction intervention and/or social support.

Reducing the African American HIV Disease Burden in the Deep South: Addressing the Role of Faith and Spirituality.

Nearly half of HIV infections in the United States are concentrated among African Americans, and over half of new HIV infections occur in the South. African Americans have poorer outcomes in the entire continua of HIV and PrEP care. Complex social, structural, and behavioral factors contribute to our nation's alarming racial disparities in HIV infection, particularly in the Deep South.

Author Correction: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Tests of General Relativity with GW170817.

The recent discovery by Advanced LIGO and Advanced Virgo of a gravitational wave signal from a binary neutron star inspiral has enabled tests of general relativity (GR) with this new type of source. This source, for the first time, permits tests of strong-field dynamics of compact binaries in the presence of matter. In this Letter, we place constraints on the dipole radiation and possible deviations from GR in the post-Newtonian coefficients that govern the inspiral regime.

Substance Use Research with Indigenous Communities: Exploring and Extending Foundational Principles of Community Psychology.

Many Indigenous communities are concerned with substance use (SU) problems and eager to advance effective solutions for their prevention and treatment. Yet these communities also are concerned about the perpetuation of colonizing, disorder-focused, stigmatizing approaches to mental health, and social narratives related to SU problems. Foundational principles of community psychology-ecological perspectives, empowerment, sociocultural competence, community inclusion and partnership, and reflective practice-provide useful frameworks for informing ethical community-based research pertaining to SU problems conducted with and by Indigenous communities.

Predicting drug activity against cancer cells by random forest models based on minimal genomic information and chemical properties.

A key goal of precision medicine is predicting the best drug therapy for a specific patient from genomic information. In oncology, cancers that appear similar pathologically can vary greatly in how they respond to the same drug. Fortunately, data from high-throughput screening programs often reveal important relationships between genomic variability of cancer cells and their response to drugs.

Mandarin tone recognition in English speakers with normal hearing and with cochlear implants.

Mandarin-speaking cochlear implant users have difficulty perceiving tonal changes in speech with current signal processing strategies. The purpose of this study was to evaluate whether English-speaking cochlear implant and normal hearing listeners can be trained to recognise closed-set Mandarin tones. The validity of using native-English speakers to evaluate Mandarin tone perception in cochlear implants was tested.

Becoming and being an environmentally 'woke' nurse: A phenomenological study.

Background: Increasing numbers of nurses view environmental activism as part of their role. No studies have explored the reasons.

Aim: This study aimed to identify what awakened and shaped US and UK nurses' environmental activism.