Synthesis of 9-(substituted phenoxycarbonyl)-10-methylacridinium trifluoromethanesulfonates: Effects of the leaving group on chemiluminescent properties.

Various 9-(substituted phenoxycarbonyl)-10-methylacridinium trifluoromethanesulfonates possessing electron-withdrawing substituents have been synthesized. The effect of substituents on the stability of the acridinium esters (AEs) at various temperatures in different buffers and the chemiluminescent properties have been examined. There was little correlation between the chemiluminescent properties of AEs and the pKa values of their associated phenols, but the steric effects of the ortho-substituents in the phenoxy group, as well as their electron-withdrawing natures, seem to play an important role in determining the properties.

Synthesis and chemiluminescent characteristics of two new acridinium esters.

Two new acridinium esters with a 2-(succinimidyloxycarbonyl)ethyl side arm, namely, 9-(2,6-dibromophenoxycarbonyl)-10-methyl-2-(2-(succinimidyloxycarbonyl)ethyl)acridinium trifluoromethanesulfonate and 9-(4-(2-(succinimidyloxycarbonyl)ethyl)phenoxycarbonyl)-2,7-dimethoxy-10-methylacridinium triflate, have been produced and characterized. The chemiluminescent properties and hydrolytic stabilities of the new acridinium esters have been investigated.

Syntheses of Hindered-Polymethylacridinium Esters with Potential for Biological Probe Nanoarchitectonics.

Novel acridinium esters containing several methyl groups, at least one of which is in the 1 or 8-position, have been synthesized and their structures established. The influence of the methyl substituents on the chemiluminescent properties of the synthesized acridinium esters has been investigated.

Cost-effectiveness of England's national 'Safe At Home' scheme for reducing hospital admissions for unintentional injury in children aged under 5.

Background: Injuries in children aged under 5 years most commonly occur in the home and disproportionately affect those living in the most disadvantaged communities. The 'Safe at Home' (SAH) national home safety equipment scheme, which ran in England between 2009 and 2011, has been shown to reduce injury-related hospital admissions, but there is little evidence of cost-effectiveness.

Materials And Methods: Cost-effectiveness analysis from a health and local government perspective.

Common protocol for validation of the QCOVID algorithm across the four UK nations.

Introduction: The QCOVID algorithm is a risk prediction tool for infection and subsequent hospitalisation/death due to SARS-CoV-2. At the time of writing, it is being used in important policy-making decisions by the UK and devolved governments for combatting the COVID-19 pandemic, including deliberations on shielding and vaccine prioritisation. There are four statistical validations exercises currently planned for the QCOVID algorithm, using data pertaining to England, Northern Ireland, Scotland and Wales, respectively.

Lung cancer: a new frontier for microbiome research and clinical translation.

The lung microbiome has been shown to reflect a range of pulmonary diseases-for example: asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Studies have now begun to show microbiological changes in the lung that correlate with lung cancer (LC) which could provide new insights into lung carcinogenesis and new biomarkers for disease screening. Clinical studies have suggested that infections with tuberculosis or pneumonia increased the risk of LC possibly through inflammatory or immunological changes.

Heart-rate variability: a biomarker to study the influence of nutrition on physiological and psychological health?

As the influence of diet on health may take place over a period of decades, there is a need for biomarkers that help to identify those aspects of nutrition that have either a positive or a negative influence. The evidence is considered that heart-rate variability (HRV) (the time differences between one beat and the next) can be used to indicate the potential health benefits of food items. Reduced HRV is associated with the development of numerous conditions for example, diabetes, cardiovascular disease, inflammation, obesity and psychiatric disorders.

Comparison of family nursing in Slovenia and Scotland: integrative review.

Aim: The aim of this study was to examine and compare the advantages and disadvantages of two systems of community nursing through the history of their development, and to compare these systems with the World Health Organization model of the Family Health Nurse.

Background: In Slovenia, the family/community nursing service is designed according to the World Health Organization policies and is performed by the generalist family/community nurse. In contrast, across Scotland there is no universal model and the current system comprises several different specialist-nursing pathways.

Executive summary and conclusions from the European Hydration Institute Expert Conference on human hydration, health, and performance.

On April 7-8, 2014, the European Hydration Institute hosted a small group of experts at Castle Combe Manor House, United Kingdom, to discuss a range of issues related to human hydration, health, and performance. The meeting included 18 recognized experts who brought a wealth of experience and knowledge to the topics under review. Eight selected topics were addressed, with the key issues being briefly presented before an in-depth discussion.

Adding 5 h delayed xenon to delayed hypothermia treatment improves long-term function in neonatal rats surviving to adulthood.

Background: We previously reported that combining immediate hypothermia with immediate or 2 h delayed inhalation of an inert gas, xenon, gave additive neuroprotection in rats after a hypoxic-ischemic insult, compared to hypothermia alone. Defining the therapeutic time window for this new combined intervention is crucial in clinical practice when immediate treatment is not always feasible. The aim of this study is to investigate whether combined hypothermia and xenon still provide neuroprotection in rats after a 5 h delay for both hypothermia and xenon.

The development of the predisposition to dehydration questionnaire.

The role played by hydration in general health and well-being is an emerging public health issue, yet there are few tools available to monitor its status in large populations. The aim was therefore to develop a questionnaire that assesses individual differences in the tendency to lose body fluid in a warm environment and hence become dehydrated. Fifty-three subjects sat in a room at 30°C for four hours and changes in mood and measures of hydration were monitored.

The effect of using isomaltulose (Palatinose™) to modulate the glycaemic properties of breakfast on the cognitive performance of children.

Purpose: Although previous research has associated the glycaemic load (GL) of a meal with cognitive functioning, typically the macro-nutrient composition of the meals has differed, raising a question as to whether the response was to GL or to the energy, nutrients or particular foods consumed. Therefore, the present study contrasted two breakfasts that offered identical levels of energy and macro-nutrients, although they differed in GL.

Methods: Using a repeated-measures, double-blind design, 75 children aged 5-11 years, from socially deprived backgrounds, attended a school breakfast club and on two occasions, at least a week apart, they consumed a meal sweetened with either isomaltulose (Palatinose™) (GL 31.

Saturday night fever in ecstasy/MDMA dance clubbers: Heightened body temperature and associated psychobiological changes.

Unlabelled: Aims and rationale: to investigate body temperature and thermal self-ratings of Ecstasy/MDMA users at a Saturday night dance club.

Methods: 68 dance clubbers (mean age 21.6 years, 30 females and 38 males), were assessed at a Saturday night dance club, then 2-3 d later.

Effects of chronic mild stress on the development of drug dependence in rats.

There is high comorbidity between depression and addiction. Features of addiction relevant to depression have been studied extensively, but less is known about features of depression relevant to addiction. Here, we have studied the effects of chronic mild stress (CMS), a valid animal model of depression, on measures of physical and psychological dependence resulting from subchronic treatment of rats with three drugs of abuse that act through disparate neurobiological mechanisms: morphine, nicotine and diazepam.

The strategies used to deal with emotion work in student paramedic practice.

Preregistration paramedic science students are quickly introduced to the reality of emergency paramedic practice (British Paramedic Association (BPA) 2008) and are expected to manage both their own emotions and those of potentially distressed patients and relatives. Despite the evident importance of emotion work, there is a lack of research evidence on this phenomenon and none at all from the student perspective. A qualitative study, using semi-structured interviews was undertaken with 8 s year paramedic science students to explore their perceptions and experiences of emotion work and the strategies used to deal with it.

Supplementation with DHA and the psychological functioning of young adults.

The grey matter of the brain contains high levels of the essential nutrient DHA. Although the role of DHA in the developing brain and in dementia has attracted attention, its influence on the brain of the healthy adult has been little considered. A total of 285 young adult females took 400 mg of DHA, in a double-blind, placebo-controlled trial, for 50 d.

The risk factors for the development of complications during the recovery phase following blunt chest wall trauma: a retrospective study.

Study Objective: The difficulties in the management of the blunt chest wall trauma patient in the Emergency Department (ED) due to the development of late complications are well recognised in the literature. The aim of this study was to investigate the risk factors for the development of complications in the recovery phase following blunt chest wall trauma.

Methods: A retrospective study was completed in which the medical notes were analysed of all blunt chest wall trauma patients presenting to a large trauma centre in South Wales in 2009 and 2010.

A study of emotion work in student paramedic practice.

Student paramedics are exposed to the harsh reality of paramedic practice early within preregistration education (British Paramedic Association (BPA) 2006). Active involvement in the emergency assessment, management and treatment of potentially life threatening and traumatic incidents involves exposure to human suffering, pain, trauma and death. Managing their own and others' emotions would appear to be integral.

Dehydration influences mood and cognition: a plausible hypothesis?

The hypothesis was considered that a low fluid intake disrupts cognition and mood. Most research has been carried out on young fit adults, who typically have exercised, often in heat. The results of these studies are inconsistent, preventing any conclusion.

Expert opinion of the risk factors for morbidity and mortality in blunt chest wall trauma: results of a national postal questionnaire survey of Emergency Departments in the United Kingdom.

Objective: Blunt chest wall trauma is a common injury treated in the Emergency Departments and has a high reported morbidity and mortality. No national guidelines exist for the management of this patient group unless the patient has severe immediate life-threatening injuries. The aim of this study was to investigate current management of blunt chest wall trauma patients in the UK and to gather expert opinion of the risk factors for morbidity and mortality.

Lack of evidence for inhibitory processes in over-selectivity.

Stimulus over-selectivity can be defined as control over behavior being exerted by one aspect of the environment at the expense of other equally salient aspects of the environment, and is a common problem for discrimination learning under conditions of cognitive strain, and in intellectual disorders. Non-clinical participants exposed to a concurrent task load were trained and tested on a two-component trial-and-error discrimination task to investigate whether inhibition plays a role in producing under-selectivity by using both summation and retardation tests. Experiment 1 found evidence for the over-selectivity effect, and replicated the finding that revaluation of a previously over-selected stimulus allows emergence of control by a previous under-selected stimulus, despite the latter stimulus receiving no direct conditioning.