Continuous Glucose Monitoring Underreports Blood Glucose During a Simulated Ultraendurance Run in Eumenorrheic Female Runners.

Purpose: Continuous-glucose-monitoring (CGM) sensors provide near-real-time glucose data and have been introduced commercially as a tool to inform nutrition decisions. The aim of this pilot study was to explore how factors such as the menstrual phase, extended running duration, and carbohydrates affect CGM outcomes among trained eumenorrheic females in an outdoor simulated ultraendurance running event.

Methods: Twelve experienced female ultrarunners (age 39 [6] y) participated in this crossover study.

Unique bibenzyl cannabinoids in the liverwort Radula marginata: parallels with Cannabis chemistry.

The potential of cannabinoids to address public health challenges has stimulated exploration into alternative sources and production technologies. Radula marginata, an endemic Aotearoa/New Zealand liverwort, produces the bibenzyl cannabinoid perrottetinene (PET), analogous to Cannabis psychoactive tetrahydrocannabinol (THC). Structural differences between PET and THC could alter therapeutic interactions and mitigate adverse side effects.

The struggles and joys of being an Indigenous researcher in the academy.

In November I took part in two very different gatherings-one in Canada, the other in Aotearoa New Zealand-which highlight both the ongoing struggles and joys of being an Indigenous researcher in the academy.

Nutritional niches of potentially endemic, facultatively anaerobic heterotrophs from an isolated Antarctic terrestrial hydrothermal refugium elucidated through metagenomics.

Background: Tramway Ridge, a geothermal Antarctic Specially Protected Area (elevation 3340 m) located near the summit of Mount Erebus, is home to a unique community composed of cosmopolitan surface-associated micro-organisms and abundant, poorly understood subsurface-associated microorganisms. Here, we use shotgun metagenomics to compare the functional capabilities of this community to those found elsewhere on Earth and to infer in situ diversity and metabolic capabilities of abundant subsurface taxa.

Results: We found that the functional potential in this community is most similar to that found in terrestrial hydrothermal environments (hot springs, sediments) and that the two dominant organisms in the subsurface carry high rates of in situ diversity which was taken as evidence of potential endemicity.

Characteristics of Children, Youth, and Young Adults With Diabetes: A Cross-Sectional Study in New Zealand Aotearoa.

The prevalence of diabetes mellitus among children, youth, and young adults is increasing, yet limited information is known about the characteristics and management of these groups with Type 1 (T1D) and Type 2 (T2D) diabetes in primary care. The aim of the study is to explore the characteristics of people with T1D and T2D aged < 25 years across the Auckland and Waikato regions of New Zealand. : Sociodemographic and clinical data were collected from electronic primary care records (February 2021-July 2022) of four primary healthcare organisations, with medication data sourced from the National Pharmaceutical dataset.

Supercapacitor-based pulse generator with waveform adjustment capability for small animal transcranial magnetic stimulation.

In transcranial magnetic stimulation (TMS), pulsed magnetic fields are applied to the brain, typically requiring high-power stimulators with high voltages and low series impedance. TMS pulse generators for small animal coils, are underexplored, with limited dedicated circuits and simulation models. Here, we present a new design for a high-power TMS pulse generator for small animals, utilizing a pre-charged supercapacitor that is sufficient to produce repeated pulses for TMS applications without the need for recharging.

Hospitalizations in patients with systemic sclerosis: Differences between limited and diffuse cutaneous subtypes.

Aim: Systemic sclerosis is associated with significant morbidity and mortality. It remains unclear from the literature if there are differences between the subtypes of systemic sclerosis and the rate of hospitalization. Our study investigates the rates of all types of hospitalizations between limited and diffuse cutaneous systemic sclerosis.

Debiasing large language models: research opportunities.

Large language models (LLMs) are powerful decision-making tools widely adopted in healthcare, finance, and transportation. Embracing the opportunities and innovations of LLMs is inevitable. However, LLMs inherit stereotypes, misrepresentations, discrimination, and societies' biases from various sources-including training data, algorithm design, and user interactions-resulting in concerns about equality, diversity, and fairness.

Identifying climate refugia for vulnerable marine ecosystem indicator taxa under future climate change scenarios.

Vulnerable Marine Ecosystems (VMEs) are recognised as having high ecological significance and susceptibility to disturbances, including climate change. One approach to providing information on the location and biological composition of these ecosystems, especially in difficult-to-reach environments such as the deep sea, is to generate spatial predictions for VME indicator taxa. In this study, the Random Forest algorithm was used to model the spatial distribution of density for 14 deep-water VME indicator taxa under current environmental conditions and future climate change scenarios (SSP2-4.

Co-occurrence of cancer and diabetes in a high-income country: Age-period-cohort projections 2020-2044.

Background: Cancer and diabetes are increasingly prevalent, and it is not unusual for an individual to have both conditions at the same time. This occurrence has significant ramifications to the person, the clinical team providing care, and the broader health system.

Research Design And Methods: For the period 2006-2019, we used national-level diabetes (Virtual Diabetes Register) and cancer (New Zealand Cancer Registry) data on nearly five million individuals over 44 million person-years of follow-up.

The role of early temperament on oral language development of New Zealand children speaking Mandarin or Cantonese.

This study investigated the role of temperament in oral language development in over 200 Mandarin and Cantonese speakers in the pre-birth longitudinal cohort study. Mothers assessed infant temperament at nine months using a five-factor Infant Behaviour Questionnaire-Revised Very Short Form. They also reported on children's vocabulary and word combinations at age two using adapted MacArthur-Bates Communicative Development Inventory short forms.

Earth's Climate History Explains Life's Temperature Optima.

Why does the growth of most life forms exhibit a narrow range of optimal temperatures below 40°C? We hypothesize that the recently identified stable range of oceanic temperatures of ~5 to 37°C for more than two billion years of Earth history tightly constrained the evolution of prokaryotic thermal performance curves to optimal temperatures for growth to less than 40°C. We tested whether competitive mechanisms reproduced the observed upper limits of life's temperature optima using simple Lotka-Volterra models of interspecific competition between organisms with different temperature optima. Model results supported our proposition whereby organisms with temperature optima up to 37°C were most competitive.

Use of Freestyle Libre 2.0 in children with type 1 diabetes mellitus and elevated HbA: Extension phase results after a 12-week randomized controlled trial.

Aim: To investigate extension phase outcomes with intermittently scanned continuous glucose monitoring (isCGM 2.0) in children with type 1 diabetes mellitus (T1DM) and elevated HbA (7.5-12.

Dynamics of infectious disease mathematical model through unsupervised stochastic neural network paradigm.

The viruses has spread globally and have been impacted lives of people socially and economically, which causes immense suffering throughout the world. Thousands of people died and millions of illnesses were brought, by the outbreak worldwide. In order to control the coronavirus pandemic, mathematical modeling proved to be an invaluable tool for analyzing and determining the potential and severity of the illness.

Seafloor sediment microtopography as a surrogate for biodiversity and ecosystem functioning.

Marine soft sediments play crucial roles in global biogeochemical cycles and biodiversity. Yet, with organisms often hidden in the sediment, they pose challenges for effective monitoring and management. This study introduces a novel approach utilizing sediment microtopography as a proxy for ecosystem functioning and biodiversity.

Ideal personhood through the ages: tracing the genealogy of the modern concepts of wellbeing.

This inquiry traces the recent history of modern conceptualizations of personhood and wellbeing. It explores a general transition from traditional frameworks emphasizing social embeddedness, external obligations, and cosmic meaning to modern views privileging self-determination, authenticity, and self-expression. The inquiry shows that contemporary conceptions of wellbeing have emerged in Western cultures through the gradual accumulation of influences, including the Enlightenment ethos, liberal ideals, romanticism, existentialism, countercultural movements, and modern psychology.

Mating Behaviour Influences the Direction and Geographic Extent of Introgression in New Zealand Fishing Spiders (Dolomedes).

Introgression is a highly influential process in evolution, where genes flow between species that are not fully reproductively isolated. Studies on introgression often focus on describing gene transfer and environmental changes that facilitate the meeting of species. However, the impact of mating systems and behaviour that facilitate gene transfer is less well-known.

The coordination chemistry and anticancer activity of organo-ruthenium(II), -iridium(III) and -rhodium(III) complexes with sulfonyl-substituted thiourea ligands.

Some half-sandwich compounds with a variety of ligands and metal centres have shown promising anticancer activity. Herein we report a series of reactions between the sulfonylthiourea ligands -TolSONHC(S)NHPh, EtSONHC(S)NHPh and CHSONHC(S)NHPh and [(η--cymene)RuCl], [(η-arene)RuCl(PR)] (arene = benzene or -cymene), [Cp*MCl(PR)] or [Cp*RhCl] (M = Ir(III), Rh(III)), Cp* = η-pentamethylcyclopentadienyl, PR = triphenylphosphine (PPh), tris(2-cyanoethyl)phosphine (tcep) and 1,3,5-triaza-7-phosphaadamantane (pta) and their corresponding piano stool complexes. Single crystal X-ray diffraction structure determinations indicated that the resulting linkage isomer of the complex, , (coordination S,N placing the sulfonyl group near the coordination sphere) or (coordination S,N, placing the sulfonyl group away from the coordination sphere), is directly related to the steric bulk around the metal centre.

Sustainable Land Use Strengthens Microbial and Herbivore Controls in Soil Food Webs in Current and Future Climates.

Climate change and land-use intensification are threatening soil communities and ecosystem functions. Understanding the combined effects of climate change and land use is crucial for predicting future impacts on soil biodiversity and ecosystem functioning in agroecosystems. Here, we used a field experiment to quantify the combined effects of climate change (warming and altered precipitation patterns) and land use (agricultural type and management intensity) on soil food webs across nematodes, micro-, and macroarthropods.

The contributions of motor skill proficiency to cognitive and social development in early childhood.

With limited evidence from intervention studies, causal relationships between motor competence and cognitive and social development have yet to be clearly established. In this research, we investigated whether a targeted training programme to improve fundamental movement skills (i.e.