Managing Recurrent Endocarditis in Substance Use Disorder: The Role of Civil Commitment and Comprehensive Care.

BACKGROUND The incidence of drug-induced infectious endocarditis is rapidly rising in the United States. Healthcare providers face different challenges in the management of infectious endocarditis in persons who inject drugs, including addiction relapse, non-compliance with treatment, and the associated social stigma. These factors collectively complicate the management of drug-induced endocarditis, requiring comprehensive strategies that address both the medical condition and the underlying substance use disorder, as well as socio-behavioral aspects of patient care.

Bipolar Ionization Did Not Reduce Airborne Bacteria in a Lecture Hall.

Ionization treatment of indoor air has attracted attention for its potential to inactivate airborne pathogens and reduce disease transmission, yet its real-world effectiveness remains unverified. We evaluated the impact of an in-duct, bipolar ionization system on airborne particles, including culturable bacteria, in a lecture hall. The ionizer was off with variable fan speed for 1 week, on with variable fan speed for a second week, and on with high and constant fan speed for a third week.

Spatial variation in housing construction material in low- and middle-income countries: A Bayesian spatial prediction model of a key infectious diseases risk factor and social determinant of health.

Housing infrastructure and quality is a major determinant of infectious disease risk and other health outcomes in regions where vector borne, waterborne and neglected tropical diseases are endemic. It is important to quantify the geographical distribution of improvements to dwelling components to identify and target resources towards populations at risk. This study aimed to model the sub-national spatial variation in housing materials using covariates with quasi-global coverage and use the resulting estimates to map predicted coverage across the world's low- and middle-income countries.

Synergistic enhancement of hydrophobic dental adhesives: autonomous strengthening, polymerization kinetics, and hydrolytic resistance.

The leading cause of composite restoration failure is recurrent marginal decay. The margin between the composite and tooth is initially sealed by a low-viscosity adhesive, but chemical, physical, and mechanical stresses work synergistically and simultaneously to degrade the adhesive, destroying the interfacial seal and providing an ideal environment for bacteria to proliferate. Our group has been developing self-strengthening adhesives with improved chemical and mechanical characteristics.

-related disorder in 87 adults: Natural history and self-sustainability.

Purpose: is one of the most frequently mutated genes in intellectual disability cohorts. Thus, far few adult-aged patients with -related disorder have been described, which limits our understanding of the disease's natural history and our ability to counsel patients and their families.

Methods: Data on patients aged 18+ years with -related disorder were collected through an online questionnaire completed by clinicians and parents.

Cerebellar Involvement in Attacks of Aquaporin-4-IgG Positive Neuromyelitis Optica Spectrum Disorder.

Objectives: To characterize the frequency and clinicoradiologic phenotype of cerebellar involvement in attacks of aquaporin-4-IgG positive neuromyelitis optica spectrum disorder (AQP4+NMOSD) which are incompletely captured in current diagnostic criteria.

Methods: Brain MRI scans from patients with AQP4+NMOSD in the Mayo Clinic database were reviewed, and those with cerebellar T2-hyperintense lesions ≤30 days from attack onset were included for clinical and radiologic characterization.

Results: From 432 patients with AQP4+NMOSD, we identified 17 (4%) with cerebellar attacks.

Methodology used to develop the minimum common data elements for surveillance and Reporting of Musculoskeletal Injuries in the MILitary (ROMMIL) statement.

Background: The objective was to summarize the methodology used to reach consensus for recommended minimum data elements that should be collected and reported when conducting injury surveillance research in military settings. This paper summarizes the methodology used to develop the international Minimum Data Elements for surveillance and Reporting of Musculoskeletal Injuries in the MILitary (ROMMIL) statement.

Methods: A Delphi methodology was employed to reach consensus for minimum reporting elements.

Temporal shifts in safety states through the COVID-19 pandemic: Insights from hidden semi-Markov models.

The COVID-19 pandemic significantly impacted transportation safety, with an increase in risky driving behaviors observed during the initial lockdown period, leading to a higher likelihood of severe crashes. However, there is limited research on the post-pandemic effects on driving behaviors and safety. This study addresses this gap by analyzing open data from the state of Virginia to examine shifts in safety states from 2016 to 2024, covering the pre-, during-, and post-pandemic periods.

Quantifying EDC Emissions from Consumer Products: A Novel Rapid Method and Its Application for Systematic Evaluation of Health Impacts.

Endocrine-disrupting chemicals (EDCs) are widely used in consumer products and have been associated with adverse public health outcomes and significant economic costs. We developed a rapid chamber method for measuring EDC emissions from consumer products, significantly reducing the time to reach steady state from weeks or months to minutes or hours. Using this method, we quantified EDC emissions from a wide range of products, determined the emission-control parameters, and established their relationship with the EDC content () and physicochemical properties.

Endovascular therapy versus medical management in isolated anterior cerebral artery acute ischemic stroke: a multinational multicenter propensity score-weighted study.

Background: Isolated anterior cerebral artery occlusions (ACAo) in patients with acute ischemic stroke present significant challenges due to their rarity. The efficacy and safety of endovascular therapy (EVT) in comparison with best medical therapy (BMT) for ACAo remains unclear. This study aimed to assess the outcomes of these treatments.

Cancer incidence associations with drinking water arsenic levels and disinfection methods in Maine, USA.

Maine is a largely rural state where nearly half of the population uses drinking water from private wells. Arsenic (As) is present in some Maine groundwater, has been linked to cancer, and a lack of testing and treatment may expose people with private wells to elevated As levels. Disinfection byproducts (DBPs) include known and suspected carcinogens that form when chlorine or chloramines are added to water.

Effectiveness of the upscaled use of a silver-ceramic (silver ionization) technology to disinfect drinking water in tanks at schools in rural India.

In many low- and middle-income countries, school children consume untreated water that has been pumped into storage tanks. The water is often of poor quality and consumption can cause gastrointestinal illnesses resulting in missed school days, growth stunting, and cognitive impairment. This study deployed a silver-ceramic technology (MadiDrop) to disinfect drinking water in school storage tanks.

Water safety planning application for aesthetic quality of drinking water.

The World Health Organization considers water quality aesthetic parameters affecting taste, odor, and appearance as factors to be monitored to determine the overall safety of water. Water safety plans (WSPs) can be used by utilities to proactively identify aesthetic hazards, rank them by likelihood of occurrence and consequence to the utility, generate risk scores, and provide direction on how to monitor, mitigate, and verify that controls are in place. The City of Wichita Falls Public Water System (CWF PWS) used the water safety planning approach to outline how aesthetics may negatively affect the system from source water, in-plant processes, and into the distribution system.

Evaluation of Apparent Metabolizable Energy and Apparent Ileal Amino Acid Digestibility of Spirulina () in Broiler Chickens and Laying Hens.

Our study objective was to determine the apparent metabolizable energy (AME) and apparent ileal amino acid digestibility (AIAAD) of spirulina fed to broiler chickens and laying hens using the difference method. In both experiments, birds were either fed corn-soybean meal basal diets, containing no spirulina and formulated to provide the nutrient requirements of either broilers or layers, or fed test diets consisting of 25% spirulina and 75% of the appropriate basal diet. Titanium dioxide was added to all diets as an indigestible marker.

Influenza virus infection and aerosol shedding kinetics in a controlled human infection model.

Unlabelled: Establishing effective mitigation strategies to reduce the spread of influenza virus requires an improved understanding of the mechanisms of transmission. We evaluated the use of a controlled human infection model using an H3N2 seasonal influenza virus to study critical aspects of transmission, including symptom progression and the dynamics of virus shedding. Eight volunteers were challenged with influenza A/Perth/16/2009 (H3N2) virus between July and September 2022 at Emory University Hospital.

Determinants of antimicrobial resistance in biosolids: A systematic review, database, and meta-analysis.

Biosolids can provide a nutrient rich soil amendment, particularly for poor soils and semi-arid or drought-prone areas. However, there are concerns that sludge and biosolids could be a source of propagation and exposure to AMR determinants such as antibiotic resistant bacteria (ARB), and antibiotic resistance genes (ARGs). To inform risk assessment efforts, a systematic literature review was performed to build a comprehensive spreadsheet database of ARB and ARG concentrations in biosolids (and some sludges specified as intended for land application), along with 69 other quantitative and qualitative meta-data fields from 68 published studies describing sampling information and processing methods that can be used for modeling purposes.

Queer- and trans-inclusive faculty hiring-A call for change.

As queer and trans scientists, we face varied and systemic barriers to our professional success, resulting in our relative absence from faculty ranks at many institutions. In this Perspective, we call for a change in faculty hiring practices and present concrete guidance to make it a more inclusive process.

Understanding of income and race disparities in hurricane evacuation is contingent upon study case and design.

As hurricanes become more frequent and destructive, understanding evacuation decision-making is crucial to refining disaster response strategies. Several studies have explored how socioeconomic characteristics such as income and race impact evacuation behavior. Most of these studies focus on a single hurricane event with the geographic extent limited to one or two states, each using a distinct study design, making them difficult to compare.

A Physically Constrained Deep-Learning Fusion Method for Estimating Surface NO Concentration from Satellite and Ground Monitors.

Accurate estimation of atmospheric chemical concentrations from multiple observations is crucial for assessing the health effects of air pollution. However, existing methods are limited by imbalanced samples from observations. Here, we introduce a novel deep-learning model-measurement fusion method (DeepMMF) constrained by physical laws inferred from a chemical transport model (CTM) to estimate NO concentrations over the Continental United States (CONUS).

Increasing phosphorus loss despite widespread concentration decline in US rivers.

The loss of phosphorous (P) from the land to aquatic systems has polluted waters and threatened food production worldwide. Systematic trend analysis of P, a nonrenewable resource, has been challenging, primarily due to sparse and inconsistent historical data. Here, we leveraged intensive hydrometeorological data and the recent renaissance of deep learning approaches to fill data gaps and reconstruct temporal trends.

Satellite-Derived, Smartphone-Delivered Geospatial Cholera Risk Information for Vulnerable Populations.

Cholera, an acute waterborne diarrheal disease, remains a major global health challenge. Despite being curable and preventable, it can be fatal if left untreated, especially for children. Bangladesh, a cholera-endemic country with a high disease burden, experiences two peaks annually, during the dry pre-monsoon spring and the wet post-monsoon fall seasons.