4,338 results match your criteria: "University of Veterinary Medicine Hannover.[Affiliation]"
Antibiotics (Basel)
October 2024
Unit for Reproductive Medicine-Clinic for Small Animals, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Antimicrobial stewardship is one of the cornerstones in the battle against antimicrobial resistance. Restrictive legislation aims to foster antimicrobial stewardship. Prophylactic prescription of antimicrobials is still a widespread practice in canine breeding management to prevent suspected infectious infertility.
View Article and Find Full Text PDFInfluenza Other Respir Viruses
October 2024
Department of Infectious Disease, Imperial College London, London, UK.
Controlled human infection models (CHIMs) are a critical tool for the understanding of infectious disease progression, characterising immune responses to infection and rapid assessment of vaccines or drug treatments. There is increasing interest in using CHIMs for vaccine development and an obvious need for widely available and fit-for-purpose challenge agents. Inno4Vac is a large European consortium working towards accelerating and de-risking the development of new vaccines, including development of CHIMs for influenza, respiratory syncytial virus and Clostridium difficile.
View Article and Find Full Text PDFJ Neuroinflammation
October 2024
Institute for Experimental Infection Research, Centre for Experimental and Clinical Infection Research, TWINCORE, Joint Venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, 30625, Hannover, Germany.
Viral encephalitis is characterized by a series of immunological reactions that can control virus infection in the brain, but dysregulated responses may cause excessive inflammation and brain damage. Microglia are brain-resident myeloid cells that are specialized in surveilling the local CNS environment and in case of viral brain infection they contribute to the control of the infection and to restriction of viral dissemination. Here, we report that after exposure to neurotropic vesicular stomatitis virus (VSV), murine in vitro microglia cultures showed rapid upregulation of a broad range of pro-inflammatory and antiviral genes, which were stably expressed over the entire 8 h infection period.
View Article and Find Full Text PDFFront Vet Sci
October 2024
Clinic for Ruminants with Ambulatory and Herd Health Services, Ludwig-Maximilians-Universität Munich, Oberschleißheim, Germany.
NPJ Vaccines
October 2024
Institute of Immunology, University Hospital Tübingen, Auf der Morgenstelle 15, 72076, Tübingen, Germany.
Among the common strategies to design next-generation COVID-19 vaccines is broadening the antigenic repertoire thereby aiming to increase efficacy against emerging variants of concern (VoC). This study describes a new Orf virus-based vector (ORFV) platform to design a multiantigenic vaccine targeting SARS-CoV-2 spike and nucleocapsid antigens. Vaccine candidates were engineered, either expressing spike protein (ORFV-S) alone or co-expressing nucleocapsid protein (ORFV-S/N).
View Article and Find Full Text PDFClin Gastroenterol Hepatol
October 2024
Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain; Ikerbasque, Basque Foundation for Science, Bilbao, Spain; Department of Medicine and Surgery, LUM University, Casamassima, Italy. Electronic address:
Background & Aims: Limiting the dietary intake of certain carbohydrates has therapeutic effects in some but not all irritable bowel syndrome (IBS) patients. We investigated genetic variation in human Carbohydrate-Active enZYmes (hCAZymes) genes in relationship to the response to a FODMAP-lowering diet in the DOMINO study.
Methods: hCAZy polymorphism was studied in patients with IBS from the dietary (FODMAP-lowering; n = 196) and medication (otilonium bromide; n = 54) arms of the DOMINO trial via targeted sequencing of 6 genes of interest (AMY2B, LCT, MGAM, MGAM2, SI, and TREH).
Animals (Basel)
October 2024
Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover (Foundation), 30559 Hannover, Germany.
The objectives of the present study were to analyze the influence of the stallions employed in the Dülmen wild horses on the genetic diversity and population substructure using Bayesian cluster analysis. The Dülmen wild horse is maintained as a unique horse population exposed to the natural conditions all year round in the Merfelder Bruch near Dülmen in Westphalia, Germany. Stallions selected for breeding have to prove their abilities to survive under this harsh environment.
View Article and Find Full Text PDFInt J Mol Sci
September 2024
Department of Small Animal Medicine, College of Veterinary Medicine, China Agriculture University, Beijing 100193, China.
Canine malignant melanoma (CMM) is highly aggressive and mostly located in the oral cavity. CMM is the predominant type of canine oral malignancy and shows striking homologies with human mucosal melanoma. In comparative oncology, canine oral melanomas (COMs), as spontaneous tumor models, have the potential to acquire a unique value as a translational model of rare human melanoma subtypes.
View Article and Find Full Text PDFVet Surg
October 2024
Clinic for Horses, University of Veterinary Medicine Hannover, Hannover, Germany.
Objective: To compare the practicability and tissue sample quality between different intestinal biopsy techniques.
Study Design: Experimental, randomized ex vivo study.
Sample Population: Small intestine of nine horses.
Br J Nutr
October 2024
Institute for Physiology and Cell Biology, University of Veterinary Medicine Hannover, Foundation, Hannover30173, Germany.
Ruminants can recycle nitrogen (N) and phosphorus (P), which are essential for vital body processes. Reduced N- and P-intake in ruminants is desirable for economic and ecologic reasons. Simultaneous modulation of mineral homoeostasis and bone metabolism occurs in young goats.
View Article and Find Full Text PDFFront Microbiol
September 2024
Department of Biological Safety, German Federal Institute for Risk Assessment, Berlin, Germany.
Two physical treatments (heat via water bath and cold air) with various temperatures (20/70/75/80°C and - 80/-90°C) and exposure times (20, 30, 40 s) were carried out to identify a decontaminating effect on zoonotic pathogens on broiler carcasses. Subsequently, carcasses were analyzed for thermotolerant , , and total colony count (TCC). Moreover, for the hot water treatment, qPCR with viable/dead differentiation (v-qPCR) was applied to detect viable but non-culturable cells (VBNC) of referred to as intact but putatively infectious units (IPIU).
View Article and Find Full Text PDFBMC Vet Res
October 2024
College of Veterinary Medicine and Agriculture, Addis Ababa University, P.O. Box 34, Bishoftu, Ethiopia.
Neuropharmacology
December 2024
Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany; Institute for Auditory Neuroscience, University Medical Center, Goettingen, Germany; Brain Mapping Unit, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISCC), Madrid, Spain; Department of Nuclear Medicine, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISCC), Madrid, Spain.
Nat Commun
October 2024
Institute of Clinical Neurobiology, University Hospital Würzburg, Würzburg, Germany.
Increasing evidence suggests an essential function for autophagy in unconventional protein secretion (UPS). However, despite its relevance for the secretion of aggregate-prone proteins, the mechanisms of secretory autophagy in neurons have remained elusive. Here we show that the lower motoneuron disease-associated guanine exchange factor Plekhg5 drives the UPS of Sod1.
View Article and Find Full Text PDFMicrobiol Spectr
November 2024
Department of Applied Biology, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia.
Unlabelled: Antimicrobial resistance is a growing global concern exacerbated by the scarcity of new medications and resistance to current antibiotics. Microbes from unexplored habitats are promising sources of natural products to combat this challenge. This study aimed to isolate bacteria producing secondary metabolites and assess their antimicrobial efficacy against human pathogens.
View Article and Find Full Text PDFSci Total Environ
December 2024
Aarhus University, Department of Ecoscience, Frederiksborgvej 399, DK-4000 Roskilde, Denmark. Electronic address:
Porcine Health Manag
October 2024
Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
Background: Within the last decades industrial swine herds in Europe grown significantly, creating an optimized reservoir for swine influenza A viruses (swIAV) to become enzootic, particularly in piglet producing herds among newborn, partly immunologically naïve piglets. To date, the only specific control measure to protect piglets from swIAV is the vaccination of sows, which provides passive immunity through maternally derived antibodies in colostrum of vaccinated sows. Interruption of infection chains through management practices have had limited success.
View Article and Find Full Text PDFJ Fish Dis
January 2025
Fish Disease Research Unit, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Hannover, Germany.
Environmental stressors such as micro- and nanosized plastic particles (MNPs) or crude oil have a detrimental effect on aquatic animals; however, the impact upon the cardiovascular system of fish remains relatively under-researched. This study presents a novel approach for investigating the effect of crude oil and MNPs on the cardiac system of fish. We used salmonid larvae and cardiac cell cultures derived from hearts of salmonid fish and exposed them to environmental stressors.
View Article and Find Full Text PDFVaccines (Basel)
September 2024
Department of BioMedical Research, University of Bern, 3008 Bern, Switzerland.
Declared as a Public Health Emergency in 2016 by the World Health Organization (WHO), the Zika virus (ZIKV) continues to cause outbreaks that are linked to increased neurological complications. Transmitted mainly by Aedes mosquitoes, the virus is spread mostly amongst several tropical regions with the potential of territorial expansion due to environmental and ecological changes. The ZIKV envelope protein's domain III, crucial for vaccine development due to its role in receptor binding and neutralizing antibody targeting, was integrated into sterically optimized AP205 VLPs to create an EDIII-based VLP vaccine.
View Article and Find Full Text PDFNat Ecol Evol
January 2025
Centre de Recherche sur la Biodiversité et l'Environnement (CRBE), UMR5300 Université Toulouse, CNRS, IRD, Toulouse INP, Université Toulouse 3 Paul Sabatier (UT3), Toulouse, France.
Sci Rep
September 2024
Clinic for Swine and Small Ruminants, Forensic Medicine and Ambulatory Service, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
This study assesses the use of fructosamine as a diagnostic tool for hyperglycemia in alpacas in view of their sensitivity to stress and susceptibility to conditions like lipid mobilization syndrome. Plasma fructosamine, like in diagnosing diabetes in cats and dogs, can reveal long-term blood glucose trends, differentiating stress-induced spikes from persistent diabetic hyperglycemia. In 125 alpacas presented as patients of a veterinary clinic, plasma glucose and fructosamine concentrations were compared for correlations with findings of the general clinical examination, laboratory parameters, demographic data, and a behavioral stress assessment processed by using principal component analysis.
View Article and Find Full Text PDFVet Med Sci
November 2024
Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany.
J Parkinsons Dis
October 2024
Laboratory for Virology and Gene Therapy, Department of Pharmacy and Pharmaceutical Sciences, KU Leuven, Leuven, Belgium.
Increasing evidence suggests a potential role for infectious pathogens in the etiology of synucleinopathies, a group of age-related neurodegenerative disorders including Parkinson's disease (PD), multiple system atrophy and dementia with Lewy bodies. In this review, we discuss the link between infections and synucleinopathies from a historical perspective, present emerging evidence that supports this link, and address current research challenges with a focus on neuroinflammation. Infectious pathogens can elicit a neuroinflammatory response and modulate genetic risk in PD and related synucleinopathies.
View Article and Find Full Text PDFClin Hemorheol Microcirc
November 2024
Institute for Animal Hygiene, Animal Welfare and Farm Animal Behavior, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
The pig (Sus scrofa) is the most widely used large animal model in Europe, with cardiovascular research being one of the main areas of application. Adequate refinement of interventional studies in this field, meeting the requirements of Russell and Burch's 3 R concept, can only be performed if blood-contacting medical devices are hemocompatible. Because most medical devices for cardiovascular interventional procedures are developed for humans, they are tested only for compatibility with human blood.
View Article and Find Full Text PDFBiom J
October 2024
Biostatistics and Medical Biometry, Medical School OWL, Bielefeld University, Bielefeld, Germany.