6 results match your criteria: "University of Verona and Azienda ospedaliera Universitaria Integrata di Verona[Affiliation]"
Evidence of protective effects of recombinant ADAMTS13 in a humanized model of sickle cell disease.
Haematologica
November 2022
Dept of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata di Verona, Policlinico GB Rossi, Verona.
Article Synopsis
- * Research indicates that inflammation plays a significant role in the complications of SCD, particularly during acute vaso-occlusive crises.
- * Administering recombinant ADAMTS13 in a mouse model of SCD showed promising results in reducing inflammation and organ damage during stress events, suggesting it could be a potential treatment for acute SCD episodes.
A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis.
Blood
December 2016
Department of Medicine, University of Verona and Azienda ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Chorea-acanthocytosis is one of the hereditary neurodegenerative disorders known as the neuroacanthocytoses. Chorea-acanthocytosis is characterized by circulating acanthocytes deficient in chorein, a protein of unknown function. We report here for the first time that chorea-acanthocytosis red cells are characterized by impaired autophagy, with cytoplasmic accumulation of active Lyn and of autophagy-related proteins Ulk1 and Atg7.
View Article and Find Full Text PDFGlobal epidemiology of nonalcoholic fatty liver disease: Meta-analytic assessment of prevalence, incidence, and outcomes.
Hepatology
October 2016
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis.
J Gastroenterol Hepatol
May 2016
Azienda USL, Outpatient Liver Clinic and Internal Medicine, NOCSAE, Modena, Italy.
Background And Aim: The magnitude of the risk of incident type 2 diabetes (T2D) and metabolic syndrome (MetS) among patients with nonalcoholic fatty liver disease (NAFLD) is poorly known. We gauged the risk of developing T2D and MetS in patients with NAFLD diagnosed by either serum liver enzymes (aminotransferases or gamma-glutamyltransferase [GGT]) or ultrasonography.
Methods: Pertinent prospective studies were identified through extensive electronic database research, and studies fulfilling enrolment criteria were included in the meta-analysis.
Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups.
Dig Liver Dis
December 2015
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
An improved understanding of non-alcoholic fatty liver disease epidemiology would lead to identification of individuals at high risk of developing chronic liver disease and extra-hepatic complications, thus contributing to more effective case finding of non-alcoholic fatty liver disease among selected groups. We aimed to illustrate the epidemiology of non-alcoholic fatty liver disease in high-risk groups, which were identified based on existing literature. To this end, PubMed was searched to retrieve original articles published until May 2015 using relevant and pertinent keywords "nonalcoholic fatty liver disease" and "diabetes", "obesity", "hyperlipidaemia", "familial heterozygous hypobetalipoproteinaemia", "hypertension", "metabolic syndrome", "ethnicity", "family history" or "genetic polymorphisms".
View Article and Find Full Text PDFPrevalence of neuropathy in type 2 diabetic patients and its association with other diabetes complications: The Verona Diabetic Foot Screening Program.
J Diabetes Complications
September 2016
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Article Synopsis
- * A total of 3,591 type 2 diabetes patients were screened, revealing a significant difference in somatic neuropathy prevalence between assessments based on symptoms (2.2% men, 5.5% women) and clinical evaluations (30.5% men, 30.8% women).
- * Key findings indicate that poor metabolic control, higher body mass index (BMI), and peripheral arteriopathy are significant predictors of somatic neuropathy in these patients.