72,859 results match your criteria: "University of Utah[Affiliation]"
Importance: Classification of persons with long COVID (LC) or post-COVID-19 condition must encompass the complexity and heterogeneity of the condition. Iterative refinement of the classification index for research is needed to incorporate newly available data as the field rapidly evolves.
Objective: To update the 2023 research index for adults with LC using additional participant data from the Researching COVID to Enhance Recovery (RECOVER-Adult) study and an expanded symptom list based on input from patient communities.
J Appl Lab Med
December 2024
Department of Pathology, University of Utah, Salt Lake City, UT, United States.
Background: Rasburicase retains activity at room temperature (RT), so specimens collected for uric acid-level monitoring require cooling protocols. Our objective was to determine if we could ease these preanalytical requirements to improve compliance while maintaining accuracy.
Methods: Fifty pairs of specimens were transported and stored either on ice or at RT.
Front Neurosci
December 2024
Department of Psychiatry, NYU Grossman School of Medicine, New York, NY, United States.
Posttraumatic stress disorder is part of a spectrum of psychological symptoms that are frequently linked with a single defining traumatic experience. Symptoms can vary over the lifespan in intensity based on additional life stressors, individual stability, and connectedness to purpose. Historically, treatment has centered on psychotropic agents and individual and group therapy to increase the individual's window of tolerance, improve emotional dysregulation, and strengthen relationships.
View Article and Find Full Text PDFOpen Forum Infect Dis
December 2024
Department of Pathology, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA.
We used molecular testing to examine the causes of bloody diarrhea in a multicenter study of pediatric gastroenteritis. Pathogens typically associated with bloody diarrhea were detected in less than half of cases, and inappropriate antibiotic use was common, supporting the use of stool testing in patients with bloody diarrhea.
View Article and Find Full Text PDFPhys Rev E
November 2024
Department of Mathematics, University of Utah, Salt Lake City, Utah 84112, USA.
The imperfect narrow escape problem considers the mean first passage time (MFPT) of a Brownian particle through one of several small, partially reactive traps on an otherwise reflecting boundary within a confining domain. Mathematically, this problem is equivalent to Poisson's equation with mixed Neumann-Robin boundary conditions. Here, we obtain this MFPT in general three-dimensional domains by using strong localized perturbation theory in the small trap limit.
View Article and Find Full Text PDFJ Dent Educ
December 2024
Faculty of Health & Life Sciences, Institute of Life Course and Medical Sciences, School of Dentistry, University of Liverpool, Liverpool, UK.
Background: Haptics-enhanced virtual reality (VR-haptic) simulation in dental education has evolved considerably during the past decade, representing a promising resource of simulation-based training opportunities to support conventional practice. We aim to summarize current literature on the applications of VR-haptics in learning, practicing, and teaching dental education.
Methods: A literature search was performed using PubMed, focusing on research articles published between January 2010 and January 2024.
Urol Oncol
December 2024
Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:
Objectives: Compare functional outcomes and treatment-related regret over 10 years in Spanish- and English-speaking Hispanic men compared to non-Hispanic men following treatment of localized prostate cancer.
Methods And Materials: Data from a prospective cohort study of men with localized prostate cancer treated with active surveillance, radical prostatectomy or radiotherapy were used to examine the effect of survey language (Spanish speaking vs. English speaking) and ethnicity (Hispanic vs.
J Mech Behav Biomed Mater
November 2024
Department of Mechanical Engineering, University of Utah, Salt Lake City, UT, USA. Electronic address:
Bracket fungi sporocarps present promising environmentally friendly alternatives to harmful and wasteful structural applications with their high strength-to-weight ratio mechanical properties. Kingdom Fungi is estimated to have over three million species, yet only 4% of the species have been described by mycologists, and their mechanical behavior has been under-explored. This work aims to characterize the material behavior and mechanical properties of bracket fungi as a whole through micro-mechanical tensile testing combined with microstructural imaging and analysis of two representative species.
View Article and Find Full Text PDFJ Natl Compr Canc Netw
December 2024
National Comprehensive Cancer Network.
Multigene panel testing has allowed for the detection of a growing number of inherited pathogenic/likely pathogenic variants in people at high risk of cancer, including endometrial cancer (EC). Hereditary syndromes associated with EC include Lynch syndrome, PTEN hamartoma tumor syndrome, and Peutz-Jeghers syndrome. This manuscript provides the latest recommendations from the NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric on the screening and management of EC in patients at high risk for these syndromes, as well as the advantages and limitations of multigene panel testing.
View Article and Find Full Text PDFJ Natl Compr Canc Netw
December 2024
National Comprehensive Cancer Network.
The NCCN Guidelines for Survivorship include recommendations for screening, evaluation, and treatment of psychosocial and physical problems resulting from adult-onset cancer and its treatment. They also include recommendations to promote healthy behaviors and immunizations in survivors and provide a framework for care coordination. These NCCN Guidelines Insights summarize the panel's current recommendations regarding sexual health and fertility.
View Article and Find Full Text PDFLeuk Lymphoma
December 2024
Hematology CHU Caen Normandie, INSERM1245, MICAH, Normandie University of Caen and Rouen, UNIROUEN, UNICAEN, Hematology Institute, University Hospital Caen, Caen, France.
Hairy cell leukemia (HCL) is an indolent malignancy of mature B-lymphocytes. While existing front-line therapies achieve excellent initial results, a significant number of patients relapse and become increasingly treatment resistant. A major molecular driver of HCL is aberrant interlocking expression of the transcription factor JunD and the intracellular signaling molecule RhoH.
View Article and Find Full Text PDFJCO Clin Cancer Inform
December 2024
Marshfield Clinic Research Institute, Marshfield, WI.
Purpose: Electronic health records (EHRs) comprise a rich source of real-world data for cancer studies, but they often lack critical structured data elements such as diagnosis date and disease stage. Fortunately, such concepts are available from hospital cancer registries. We describe experiences from integrating cancer registry data with EHR and billing data in an interoperable data model across a multisite clinical research network.
View Article and Find Full Text PDFPediatr Crit Care Med
December 2024
Department of Pediatrics, Division of Critical Care, University of Utah, Salt Lake City, UT.
Objectives: Describe β2-agonists, steroids, hypertonic saline (HTS), n-acetylcysteine (NAC), and dornase alfa (DA) use to treat bronchiolitis, factors associated with use, and associations between use and PICU length of stay (LOS).
Design: Retrospective, multicenter cohort study.
Setting: PICUs in the Pediatric Health Information System database.
Anesth Analg
January 2025
From the Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan.
Background: Sugammadex was initially approved for reversal of neuromuscular blockade in adults in the United States in 2015. Limited data suggest sugammadex is widely used in pediatric anesthesia practice however the factors influencing use are not known. We explore patient, surgical, and institutional factors associated with the decision to use sugammadex versus neostigmine or no reversal, and the decision to use 2 mg/kg vs 4 mg/kg dosing.
View Article and Find Full Text PDFPlast Reconstr Surg
December 2024
Division of Plastic and Reconstructive Surgery, Department of Surgery, Spencer Fox Eccles School of Medicine at the University of Utah and Intermountain Primary Children's Hospital, Salt Lake City, UT, USA.
Background: Simple syndactyly is a common congenital upper extremity difference. Traditional reconstructive approaches utilize skin grafts; however, recent studies suggest skin graftless techniques may improve outcomes. We hypothesized that patients who underwent reconstruction with a skin graftless dorsal metacarpal island VY advancement flap would have fewer postoperative complications compared to those released with a dorsal rectangular flap with skin grafts.
View Article and Find Full Text PDFJ Endocr Soc
November 2024
Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Context: Polycystic ovary syndrome (PCOS) affects 10% of women of reproductive age. The genetic architecture of the disease is emerging, but there is little data exploring the effect of genetic risk on clinical presentation.
Objective: We hypothesized that genetic risk loci would influence measurable phenotypic traits.
MethodsX
December 2024
Department of Radiology and Imaging Sciences, University of Utah, 729 Arapeen Drive, Salt Lake City, UT, 84109, USA.
This study introduces a comprehensive hardware-software framework designed to enhance the quality of block face image capture-an essential intermediary step for registering 2D histology images to ex vivo magnetic resonance (MR) images. A customized camera mounting and lighting system is employed to maintain consistent relative positioning and lighting conditions. Departing from traditional transparent paraffin, dyed paraffin is utilized to enhance contrast for subsequent automatic segmentation.
View Article and Find Full Text PDFAfr Urol
June 2024
Division of Urology, Department of Surgery, University of Utah School of Medicine, United States of America.
Bladder exstrophy-epispadias-cloacal exstrophy complex (BEEC) is a spectrum of congenital urologic anomalies that involve the bladder, urethra, genitalia, and pelvic musculoskeletal system, and can affect urinary continence, sexual health, and fertility. BEEC includes a wide spectrum of anatomical abnormalities with different levels of severity: epispadias represents the mildest phenotype, classic bladder exstrophy (CBE) is the most common defect, and cloacal exstrophy (CE) - often referred to as omphalocele, exstrophy, imperforate anus, and spinal defects (OEIS) complex - is the most severe form. BEEC disorders cause significant health problems and affect the health-related quality of life (QoL) of affected individuals.
View Article and Find Full Text PDFAfr Urol
June 2024
Johns Hopkins Hospital, Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.
New Microbes New Infect
December 2024
Department of Research, Medical Research Circle (MedReC), Goma, Democratic Republic of the Congo.
J Clin Med
November 2024
Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig de la Vall d'Hebron 171, 08035 Barcelona, Spain.
: A high number of patients who suffer the amputation of a lower limb will present psychological problems such as anxiety, depression, and post-traumatic stress disorder after surgery. This study embodies participants in a self-avatar with a right lower-limb amputation in a virtual reality environment. The aim was to determine if this experience increases anxiety levels compared to embodiment in a normal avatar.
View Article and Find Full Text PDFCells
December 2024
Departments of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Solid tumors vary by the immunogenic potential of the tumor microenvironment (TME) and the likelihood of response to immunotherapy. The emerging literature has identified key immune cell populations that significantly impact immune activation or suppression within the TME. This study investigated candidate T-cell populations and their differential infiltration within different tumor types as estimated from mRNA co-expression levels of the corresponding cellular markers.
View Article and Find Full Text PDFCancers (Basel)
November 2024
Center for Immuno-Oncology, National Cancer Institute, National Institute of Health, Bethesda, MD 20894, USA.
Olfactory neuroblastoma (ONB), sinonasal undifferentiated carcinoma (SNUC), and sinonasal neuroendocrine carcinoma (SNEC) are rare malignancies arising from the sinonasal tract with limited therapeutic options. The expression of the somatostatin receptor 2 gene (), which is expressed in other neuroendocrine neoplasms and is therapeutically actionable, has been reported in these tumors. Here, we analyzed gene expression and its associations with genomic features, established biomarkers predicting of immune response, and the tumor immune microenvironment in a cohort of ONB, SNUC, and SNEC tumor samples (26, 13, and 8 samples, respectively) from a real-world database.
View Article and Find Full Text PDFBMC Glob Public Health
July 2024
Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
Background: Globally, herpes simplex virus (HSV)-2 and -1 infections contribute to a large disease burden, but their full economic consequences remain unclear. This study aims to estimate the global economic impact of genital HSV-2 and HSV-1 infection and its consequences for people with genital ulcer disease, neonatal herpes, and human immunodeficiency virus (HIV) infection attributable to HSV-2.
Methods: Using a societal perspective, the economic burden was calculated at the country level and presented by World Health Organization (WHO) regions and World-Bank income levels.
Pediatr Res
December 2024
Division of Newborn Medicine, Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA.
Artificial intelligence (AI) is a rapidly advancing area with growing clinical applications in healthcare. The neonatal intensive care unit (NICU) produces large amounts of multidimensional data allowing AI and machine learning (ML) new avenues to improve early diagnosis, enhance monitoring, and provide highly-targeted treatment approaches. In this article, we review recent clinical applications of AI to important neonatal problems, including sepsis, retinopathy of prematurity, bronchopulmonary dysplasia, and others.
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