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RSC Adv
November 2024
Department of Chemistry, University of Turku Henrikinkatu 2 20500 Turku Finland
A fluorescently tagged oligonucleotide hybridization probe incorporating a single 5-mercuricytosine residue was synthesized and found to adsorb on polydopamine nanoparticles much more strongly than its unmetallated counterpart. Hybridization with target sequences led to release of the probe from the nanoparticle to varying degrees depending on the nucleobase opposite to 5-mercuricytosine.
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