French-Speaking Network of Pharmacogenetics (RNPGx) Recommendations for Clinical Use of Mavacamten.

Mavacamten, the first drug in the class of β-cardiac myosin modulator, is used for the treatment of patients with hypertrophic cardiomyopathy. This orally administered drug demonstrates wide interpatient variability in pharmacokinetics parameters, due in part to variant CYP2C19 alleles. Individuals who are CYP2C19 poor metabolizers have increased exposure and are at increased risk of reduced cardiac hypercontractility.

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Introduction: Epistaxis in children is a very common reason for consultation in ENT and pediatric emergencies. Most of these epistaxis are benign, but it is their recurrence that motivates anxious parents, to consult. Allergic rhinitis is a common pathology among children in Tunisia, it seemed interesting to us to study the association between allergic rhinitis and epistaxis.

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Introduction: Childhood obesity, a true international epidemic, is a multifactorial pathology including genetic and environmental factors.

Aim: Determine the prevalence and risk factors of overweight in Tunisian schoolchildren in the Bardo region, an urban department of the Tunis governorate.

Methods: Descriptive and cross-sectional study involving schoolchildren aged between 10 and 12 years old.

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Unlabelled: Introduction-Aim: Clinical reasoning in situations of uncertainty is a skill to be acquired from initial training. The aim of this study was to evaluate the clinical reasoning ability in a context of uncertainty of health science students using the Script Concordance Test (SCT).

Methods: This was a cross-sectional and descriptive study which included students in the third year of the National License in Anesthesia-Resuscitation, with their consent, and a panel of experts made up of ten members.

Evaluation of learning abilities after role-playing method: Comparing outcomes of Active and Observer.

Introduction: During a role-play simulation session, despite supporting observer learning, educators disagree about whether the learning outcomes of observers are like those of active participants.

Aim: Evaluation of the degree of knowledge acquisition by these two types of learners during the same role-play session.

Methods: We carried out a quasi-experimental pre-post intervention study to identify the learning outcomes among learners serving in observer (group 1) and active (group 2) roles during a role-play simulation session.

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Non.

Ameliorative Effects of Pearl Millet ( L.) Against Hydrogen Peroxide Induced Cognitive Impairment and Oxidative Stress in Rats.

Pearl millet (PM) ( L.) contains a wide variety of bioactive compounds, such as polyphenols, mostly flavonoids and phenolic acids. In the present study, we investigated the effects of PM activity against hydrogen peroxide (HO)-induced behavior impairment and oxidative damage in rats.

Decoding the pathological and genomic profile of epithelial ovarian cancer.

Ovarian cancer (OC) is one of the most common cancers in women, with a high mortality rate. Most of published studies have been focused on Caucasian populations, with the need to explore biological features and clinical outcomes of patients from other ethnicities. We described clinical outcome (progression-free survival and overall survival) and biomarkers associated with survival in a cohort of patients with OC from Tunisia.

Effect of extract on probiotic properties of isolated from camel milk in the region of El Oued (Algeria).

The current study focuses on the effect of extract on the probiotic properties of lactic acid bacteria isolated from camel milk in the region of El Oued (Algeria). Chromatographic analysis by HPLC was carried out to detect the most important compounds extracted from the plant. The total phenolic and flavonoid contents were determined using the colorimetric procedures Folin-Ciocalteu and aluminum chloride.

Barriers to Applying Knowledge Gained Through an Implementation Research Massive Open Online Course: An Explanatory Qualitative Study.

This study explores the barriers encountered by participants in applying knowledge gained from a massive open online course (MOOC) on implementation research (IR), particularly among learners in low- and middle-income countries (LMICs). Despite the rising demand for quality IR training, access remains limited in LMICs. The IR MOOC, created by the Special Program for Research and Training in Tropical Diseases, seeks to bridge this gap by providing free online IR training.

Single-stage surgical management of simultaneous pulmonary and splenic hydatidosis: A rare case report.

Introduction: hydatid disease, caused by Echinococcus granulosus, primarily affects the liver and lungs, with splenic involvement being exceedingly rare, occurring in only 0.5 % of cases. This case report highlights a 17-year-old male presenting with a complicated hydatid cyst in the lung, along with an incidental splenic cyst, emphasizing the importance of single-stage surgery in treating multi-organ hydatid disease.