2,984 results match your criteria: "University of Tunis El manar[Affiliation]"

Objectives: Evaluate diabetic patients' knowledge, practices, and the prevalence of complications during Ramadan fasting (RF) before and after an education program.

Methods: We conducted a prospective study including 140 consecutive diabetic patients (DP) who intended to observe RF in 2023. Patients underwent a questionnaire and received pre-Ramadan education (PRE) according to the IDF-DAR 2021 recommendations.

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Rapid detection of SARS-CoV-2 RNA using a one-step fast multiplex RT-PCR coupled to lateral flow immunoassay.

BMC Infect Dis

December 2024

Laboratory of Molecular Epidemiology and Experimental Pathology, LR16IPT04, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, LR16IPT04, Tunisia.

Background: The COVID-19 has put emphasis on pivotal needs for diagnosis and surveillance worldwide, with the subsequent shortage of diagnostic reagents and kits. Therefore, it has become strategic for the countries to access diagnostics, expand testing capacity, and develop their own diagnostic capabilities and alternative rapid accurate nucleic acid diagnostics that are at lower costs. Here, we propose a visual SARS-CoV-2 detection using a one-step fast multiplex reverse transcription-PCR (RT-PCR) amplification coupled to lateral flow immunoassay detection on a PCRD device (Abingdon Health, UK).

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Associations of HLA-G 3'UTR polymorphisms and increased HLA-G expression with gastric cancer susceptibility and prognosis.

Immunobiology

December 2024

Laboratory of Microorganisms and Active Biomolecules (LR03ES03), Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia. Electronic address:

Background: Gastric cancer (GC) remains a serious health concern and is characterized by a multifactorial etiology involving both genetic and epigenetic factors. The aim of the current study was to examine the relationship between Human leukocyte antigen (HLA)-G 3'UTR polymorphisms and the expression of HLA-G in both tumor tissues and plasma samples from patients with GC in the Tunisian population.

Methods: HLA-G 3'UTR polymorphisms (14pb Insertion/deletion and + 3142C/G) were identified by polymerase chain reaction (PCR) or Sanger sequencing.

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This research paper investigates the application of Genetic Algorithms (GA) in optimizing Artificial Neural Networks (ANN) for phoneme recognition. The study examines the formalism of GA, their parameters, and operators, and describes the genetic strategy adopted for phoneme recognition using the TIMIT sound database. The paper presents the outcomes of experiments conducted on the phonemes of the test base and the DR1 dialect learning base of the TIMIT base, and compares the recognition rates obtained by learning and testing with those guided by Self-Organizing Map (SOM) experiments.

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A consistent part of gas sensor research activities aims to improve sensing performances by synthesizing new sensing materials, improving the selection of elements in arrays, and optimizing the feature extraction and classification algorithms. This paper combines most of these aspects to confer selectivity to a low-selectivity sensor by using feature extraction algorithms applied to the sensor response kinetics. Several algorithms were employed to represent the kinetic behavior of the sensor response during the adsorption and desorption phases.

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The study of the polyopisthocotylan parasites of marine fishes in the western Mediterranean is carried on using an integrative approach combining morphology and DNA barcodes. n. gen.

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Introduction: breaches of research integrity have risen during these years. Tunisia´s stance regarding scientific integrity remains unknown. The aim of our study was to identify the reasons for the retraction of Tunisia-affiliated publications in the biomedical field, to describe the characteristics of these retractions, and to assess the position of Tunisian legislation regarding breaches of research integrity.

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Acantholytic Dyskeratotic Acanthoma of the Nail Revealed by a Longitudinal Erythronychia.

Skin Appendage Disord

December 2024

Dermatology Department, Habib Thameur Hospital, "Genodermatoses and Cancers LR12SP03", Tunis, Tunisia.

Introduction: Focal acantholytic dyskeratosis is a distinctive histological pattern first described by Ackerman in 1972, consisting of focal suprabasal clefts in the epidermis and dyskeratotic cells at all levels of the epidermis with hyperkeratosis and parakeratosis. The first case of subungual acantholytic dyskeratosis acanthoma (ADA) was reported in 1990. This subungual variant is a very rare entity.

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Introduction: Lichen planus pigmentosus (LPP) is an acquired pigmentary disorder affecting the dark-skinned population. There is a wide range of differentials, with substantial clinicopathological overlap. Dermoscopy may contribute to the better characterization of this dermatosis.

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Pre-sacral glomangioma: a rare localization of glomus tumors: case report.

Ann Med Surg (Lond)

December 2024

General Surgery Department "B", La Rabta Hospital, The Faculty of Medicine, The University of Tunis El Manar, Tunis, Tunisia.

Introduction And Importance: Deep-located glomangiomas are rarely reported. Because of their scarcity, treatment strategy is hard to establish. Herein, the authors report the first case to our knowledge of pre-sacral glomangioma.

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Appendiceal diverticulitis: A rare case report highlighting diagnostic challenges and complication risks.

Int J Surg Case Rep

January 2025

General Surgery Department, Mahmoud El Matri Hospital, V59M+628, Ariana, Tunisia; Faculty of Medicine of Tunis, University of Tunis El Manar, R534+F9H, Rue de la Faculté de Médecine, Tunis, Tunisia.

Introduction And Importance: Diverticular disease of the appendix is a rare condition often mistaken for acute appendicitis, with most cases diagnosed incidentally during histopathology, underscoring the importance of comprehensive pathological evaluation for accurate diagnosis.

Case Presentation: A 34-year-old male presented with one day of periumbilical pain migrating to the right iliac fossa, without vomiting or bowel changes. Clinical examination revealed tenderness in the RIF.

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Introduction: Intestinal tuberculosis (ITB), a rare yet severe manifestation of infection, poses significant diagnostic and therapeutic challenges due to its nonspecific clinical presentation. Perforation, a life-threatening complication, necessitates prompt surgical intervention and effective antituberculous therapy.

Case Presentation: This case study highlights a 41-year-old immunocompetent male who presented with fever, abdominal pain, vomiting, and significant weight loss.

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Objectives: The objective of this study is to assess the cost utility of the implementation of the human papillomavirus (HPV) vaccination programme in Tunisia in addition to the current cytology screening strategy. This study is very important to guide health policy decision-makers and to help them allocate their scarce healthcare resources.

Design: We used a previously described Markov model on the Online Cost Effectiveness Analysis tool programmed with R Software.

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Article Synopsis
  • * A specific density functional method (ωB97XD with 6-31G(d)/Def2-TZVP basis set) is identified as the most accurate for simulating how MPr binds to graphene, and simplifying the model speeds up calculations without losing important optoelectronic properties.
  • * ZnPr shows the best light harvesting efficiency, while CdPr and HgPr retain effective photosensitizing properties when attached to graphene, especially in larger graphene structures (over 500 atoms).
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X-chromosome-wide association study for Alzheimer's disease.

Mol Psychiatry

December 2024

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.

Article Synopsis
  • A study was conducted to investigate the X-chromosome's role in Alzheimer's Disease (AD), which had been overlooked in previous genome-wide association studies.
  • The research included 115,841 AD cases and 613,671 controls, considering different X-chromosome inactivation (XCI) states in females.
  • While no strong genetic risk factors for AD were found on the X-chromosome, seven significant loci were identified, suggesting areas for future research.
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Article Synopsis
  • A new tool called NeuroVar was developed to help visualize and analyze large genomic data, specifically focusing on neurological diseases.
  • It uses an interactive Shiny application and a standalone desktop version for easy access and user experience.
  • NeuroVar allows users to explore genetic variations and gene expression profiles by filtering data from the ClinGen database, and it's available for free on GitHub.
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Article Synopsis
  • The article discusses a rare genetic abnormality involving deletions on chromosome 11, specifically between the 11q13 and 11q23 regions, which can lead to various clinical features including intellectual disabilities and malformations, though these do not consistently correlate with specific genetic patterns.* -
  • The case study focuses on a 9-year-old boy exhibiting Sprengel's deformity, iris and chorioretinal coloboma, and mild motor development delay, identified to have a significant interstitial deletion on chromosome 11 through advanced genetic testing methods.* -
  • The findings emphasize the variability in symptoms associated with 11q deletions and suggest that the observed deformities might not have a direct genetic link but rather could be
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Atomic Force Microsocopy: Key Unconventional Approach for Bacterial Nanotubes Characterization In Vivo.

ACS Omega

November 2024

Laboratoire de Physique des Solides (LPS), UMR CNRS 8502, University Paris-Saclay, University Paris-Sud, Orsay 91405, France.

Article Synopsis
  • Bacterial communication plays a critical role in controlling growth and addressing issues like antimicrobial resistance and energy production in Microbial Fuel Cells.
  • Recent findings have identified a novel type of communication between bacteria using nanotubes, which are tiny filaments enabling direct nutrient exchange between neighboring cells.
  • This study utilizes atomic force microscopy (AFM) in liquid to provide the first direct visualization of bacterial nanotubes on live bacteria, shedding light on their properties and potential applications in managing bacterial behavior.
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Article Synopsis
  • * A case study of a 54-year-old woman with chronic left upper quadrant pain led to the discovery of a 3.9 cm non-vascular splenic mass, confirmed as cystic lymphangioma through imaging and requiring laparoscopic splenectomy for symptomatic relief.
  • * Though rare in adults, splenic cystic lymphangiomas can necessitate surgery if symptomatic, with imaging being crucial for diagnosis, and laparoscopic splenectomy being the preferred treatment due to its effectiveness and safety.
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Objective: Conflicting evidence has arisen from the few studies that have examined the role of the prefrontal cortex and executive control functions in theory of mind (ToM). Moreover, the involvement of other cognitive domains in the ability to infer mental states is still under debate. This study aims to examine, in addition to the potential contribution of executive functions, the role of cognitive estimation in ToM abilities, given that cognitive estimation processes are strongly associated with some aspects of executive control functions.

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Article Synopsis
  • HLA-G 14-bp insertion/deletion polymorphism is linked to cancer risk, particularly associated with the D allele, suggesting it may contribute to cancer cell escape mechanisms.
  • A meta-analysis of 39 studies showed a significant association between this polymorphism and breast cancer, with specific variations in risk based on ethnicity and geographic location.
  • Significant cancer risks linked to the D allele were observed in populations from North Africa, the Middle East, and South America, but no such risks were noted in Europe or North Asia.
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