3,252 results match your criteria: "University of Tunis[Affiliation]"
Intestinal tuberculosis complicated with perforation in an immunocompetent patient: Case report and review of the literature.
Heliyon
October 2024
University of Tunis El Manar Faculty of Medicine of Tunis, Department of General Surgery, Trauma Center Ben Arous, Tunisia.
Introduction: Intestinal tuberculosis (ITB), a rare yet severe manifestation of infection, poses significant diagnostic and therapeutic challenges due to its nonspecific clinical presentation. Perforation, a life-threatening complication, necessitates prompt surgical intervention and effective antituberculous therapy.
Case Presentation: This case study highlights a 41-year-old immunocompetent male who presented with fever, abdominal pain, vomiting, and significant weight loss.
Cost-effectiveness of human papillomavirus (HPV) vaccination in Tunisia: a modelling study.
BMJ Open
December 2024
Institut Salah-Azaiz, Tunis, Tunisia.
Objectives: The objective of this study is to assess the cost utility of the implementation of the human papillomavirus (HPV) vaccination programme in Tunisia in addition to the current cytology screening strategy. This study is very important to guide health policy decision-makers and to help them allocate their scarce healthcare resources.
Design: We used a previously described Markov model on the Online Cost Effectiveness Analysis tool programmed with R Software.
Density Functional Theory (DFT) and Time-Dependent DFT (TDDFT) Studies of Porphyrin Adsorption on Graphene: Insights on the Effect of Substituents and Central Metal on Adsorption Energies.
J Comput Chem
January 2025
Departament de Química Física and Institut de Química Teorica i Computacional (IQTCUB), Universitat de Barcelona, Barcelona, Spain.
Article Synopsis
- * A specific density functional method (ωB97XD with 6-31G(d)/Def2-TZVP basis set) is identified as the most accurate for simulating how MPr binds to graphene, and simplifying the model speeds up calculations without losing important optoelectronic properties.
- * ZnPr shows the best light harvesting efficiency, while CdPr and HgPr retain effective photosensitizing properties when attached to graphene, especially in larger graphene structures (over 500 atoms).
X-chromosome-wide association study for Alzheimer's disease.
Mol Psychiatry
December 2024
Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.
Article Synopsis
- A study was conducted to investigate the X-chromosome's role in Alzheimer's Disease (AD), which had been overlooked in previous genome-wide association studies.
- The research included 115,841 AD cases and 613,671 controls, considering different X-chromosome inactivation (XCI) states in females.
- While no strong genetic risk factors for AD were found on the X-chromosome, seven significant loci were identified, suggesting areas for future research.
NeuroVar: an open-source tool for the visualization of gene expression and variation data for biomarkers of neurological diseases.
GigaByte
November 2024
Department of Computer Science, Faculty of Science, University of Ibadan, 200132, Ibadan, Oyo State, Nigeria.
Article Synopsis
- A new tool called NeuroVar was developed to help visualize and analyze large genomic data, specifically focusing on neurological diseases.
- It uses an interactive Shiny application and a standalone desktop version for easy access and user experience.
- NeuroVar allows users to explore genetic variations and gene expression profiles by filtering data from the ClinGen database, and it's available for free on GitHub.
Interstitial 11q deletion in a patient with Sprengel's deformity: a case report and review of the literature.
Mol Cytogenet
December 2024
Department of Genetics, Charles Nicolle Hospital, Tunis, Tunisia.
Article Synopsis
- The article discusses a rare genetic abnormality involving deletions on chromosome 11, specifically between the 11q13 and 11q23 regions, which can lead to various clinical features including intellectual disabilities and malformations, though these do not consistently correlate with specific genetic patterns.* -
- The case study focuses on a 9-year-old boy exhibiting Sprengel's deformity, iris and chorioretinal coloboma, and mild motor development delay, identified to have a significant interstitial deletion on chromosome 11 through advanced genetic testing methods.* -
- The findings emphasize the variability in symptoms associated with 11q deletions and suggest that the observed deformities might not have a direct genetic link but rather could be
Atomic Force Microsocopy: Key Unconventional Approach for Bacterial Nanotubes Characterization In Vivo.
ACS Omega
November 2024
Laboratoire de Physique des Solides (LPS), UMR CNRS 8502, University Paris-Saclay, University Paris-Sud, Orsay 91405, France.
Article Synopsis
- Bacterial communication plays a critical role in controlling growth and addressing issues like antimicrobial resistance and energy production in Microbial Fuel Cells.
- Recent findings have identified a novel type of communication between bacteria using nanotubes, which are tiny filaments enabling direct nutrient exchange between neighboring cells.
- This study utilizes atomic force microscopy (AFM) in liquid to provide the first direct visualization of bacterial nanotubes on live bacteria, shedding light on their properties and potential applications in managing bacterial behavior.
Symptomatic diffuse cystic lymphangioma of the spleen in an adult: A case report.
Int J Surg Case Rep
November 2024
Department of General Surgery, Trauma and Burns Center, Ben Arous, University of Tunis El Manar, Tunisia.
Article Synopsis
- * A case study of a 54-year-old woman with chronic left upper quadrant pain led to the discovery of a 3.9 cm non-vascular splenic mass, confirmed as cystic lymphangioma through imaging and requiring laparoscopic splenectomy for symptomatic relief.
- * Though rare in adults, splenic cystic lymphangiomas can necessitate surgery if symptomatic, with imaging being crucial for diagnosis, and laparoscopic splenectomy being the preferred treatment due to its effectiveness and safety.
Relationship Between Cognitive Estimation, Executive Functions, and Theory of Mind in Patients With Prefrontal Cortex Damage.
Arch Clin Neuropsychol
November 2024
Univ Angers, Universite de Nantes, LPPL, SFR CONFLUENCES, 2 Boulevard Lavoisier, 49045 Angers Cedex 01, France.
Objective: Conflicting evidence has arisen from the few studies that have examined the role of the prefrontal cortex and executive control functions in theory of mind (ToM). Moreover, the involvement of other cognitive domains in the ability to infer mental states is still under debate. This study aims to examine, in addition to the potential contribution of executive functions, the role of cognitive estimation in ToM abilities, given that cognitive estimation processes are strongly associated with some aspects of executive control functions.
View Article and Find Full Text PDFThe 14-bp insertion/deletion as a promising gene polymorphism to understand cancer risk: Evidence from a systematic review and comprehensive meta-analysis.
Heliyon
November 2024
Laboratory of Microorganismes and Active Biomolecules, Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Article Synopsis
- HLA-G 14-bp insertion/deletion polymorphism is linked to cancer risk, particularly associated with the D allele, suggesting it may contribute to cancer cell escape mechanisms.
- A meta-analysis of 39 studies showed a significant association between this polymorphism and breast cancer, with specific variations in risk based on ethnicity and geographic location.
- Significant cancer risks linked to the D allele were observed in populations from North Africa, the Middle East, and South America, but no such risks were noted in Europe or North Asia.
Predictive Factors for Fertility of Daughter Cysts in Hepatic Cystic Echinococcosis and Insights into the Origin of Daughter Cysts.
Surg Infect (Larchmt)
November 2024
Faculty of Medicine, Department of General and Digestive Surgery, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.
The cycle of and its developmental potential has always been a subject of debate. While the origin of protoscoleces was well defined, the origin of daughter cysts (DC) was still a contentious topic, and several hypotheses have been proposed. The aim of this work was to study the fertility of DC and its predictive factors in order to determine its origin.
View Article and Find Full Text PDFExploring Polysaccharides: Extraction, Characterization, and Analysis of Antioxidant and Antimicrobial Properties.
Polymers (Basel)
November 2024
Laboratory of Biotechnology and Biogeoresources Valorization, Higher Institute of Biotechnology of Sidi Thabet (ISBST), LR11ES31, Ariana 2020, Tunisia.
Article Synopsis
- - Polysaccharides were extracted from leaves (WSPRaL) and stems (WSPRaS) of a plant, yielding about 3% and 3.25%, respectively, with varying compositions of proteins, lipids, and sugars.
- - Detailed analyses showed that WSPRaL and WSPRaS contain different types of carbohydrates, with SEM and FT-IR used to examine their microstructure and physicochemical properties.
- - The polysaccharides demonstrated strong antioxidant, antibacterial, and biofilm-inhibitory activities, suggesting their potential as functional ingredients in the food and nutraceutical industries.
Uncovered: Integrating Experimental and Computational Approaches to Antibacterial and Phytochemical Profiling.
Pharmaceuticals (Basel)
November 2024
Department of Biology, College of Science, University of Ha'il, Ha'il 81451, Saudi Arabia.
Article Synopsis
- - The study investigates the biological properties of ginger rhizome grown in Sudan, focusing on its antibacterial, antioxidant, and phytochemical properties to assess its potential for medicinal use
- - Results show that the Sudanese ginger extract exhibits moderate antibacterial activity against various bacteria, with specific inhibition and bactericidal concentrations identified, alongside a diverse range of chemical constituents found through phytochemical screening
- - The research suggests a promising future for ginger rhizome in pharmaceutical development, with detailed molecular interactions supporting its antimicrobial potential, as revealed by GC-MS analysis and computational studies
In-Depth Analysis of L. Leaf Extract: Alleviating Pulmonary Histological Disturbances, Pro-Inflammatory Responses, and Oxidative Stress from Isolated or Combined Exposure to Inhaled Toluene and Noise in Rats.
Biology (Basel)
November 2024
Laboratory of Research "LR 23/ES/10": Population Pathology, Environmental Aggressors, Alternative Therapy, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis 1068, Tunisia.
Article Synopsis
- This study examined the lung damage in rats due to exposure to inhaled toluene and noise, focusing on the protective effects of L. leaf extract (OLE).
- Rats were divided into groups based on different exposure combinations and received OLE treatment over six weeks.
- Results showed that toluene and noise exposure caused significant lung tissue damage and inflammation, while OLE treatment reduced oxidative stress and inflammation, suggesting its potential as a therapeutic agent for lung health.
Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81.
Sci Rep
November 2024
Faculty of Medicine of Tunis - LR99ES09 Research Laboratory «Antimicrobial resistance», University of Tunis El Manar, 1007, Tunis, Tunisia.
Article Synopsis
- Fluoroquinolone-resistant (FQs-R) E. coli from patients undergoing prostate biopsies are increasingly common, raising concerns about using FQs for infection prevention.
- A study between 2016 and 2018 found that 61.06% of patients carried FQs-R Enterobacterales, primarily E. coli, with varying resistance profiles linked to specific genetic mutations.
- The research highlighted that these resistance mechanisms, including mutations in the gyrA and parC genes as well as certain plasmid-mediated resistance genes, significantly elevate the Minimum Inhibitory Concentrations (MICs), posing a risk for post-procedure infections.
Characterization of Yeast Isolated from the Gut Microbiota of Tunisian Children with Autism Spectrum Disorder.
J Fungi (Basel)
October 2024
Department of Immunology, Microbiology and Parasitology, Faculty of Medicine and Nursing, University of the Basque Country, UPV/EHU, 48080 Bilbao, Spain.
Article Synopsis
- Research on the microbiota-gut-brain axis in autism has largely focused on bacteria, with fungi being underexplored, prompting a study on fungal involvement in Tunisian children with autism spectrum disorder.
- The study involved fecal sample analysis from 28 autistic children and 46 controls; they identified fungal isolates and tested their antifungal susceptibility and virulence factors.
- Results showed a significant presence of fungi in both groups, with specific antifungal resistance and virulence traits in the isolates, indicating a potential link between gut fungi and autism that warrants further investigation.
High Prevalence of aCL-IgA and aβ2GPI-IgA in Drug-Free Schizophrenia Patients: Evidence of a Potential Autoimmune Link.
Antibodies (Basel)
November 2024
Faculty of Medicine of Sousse, University of Sousse, Sousse 4002, Tunisia.
Article Synopsis
- Schizophrenia (SZ) may have an autoimmune aspect, as indicated by higher levels of antiphospholipid antibodies in patients compared to healthy individuals.
- * The study analyzed serum samples from 80 drug-free SZ patients and 80 matched controls, finding significantly elevated aCL-IgM, aCL-IgA, and aβ2GPI-IgA levels in SZ patients.
- * These findings suggest a potential autoimmune link in SZ, warranting further research into the role of these antibodies in the disease's development and their connection to antiphospholipid syndrome.
French-Speaking Network of Pharmacogenetics (RNPGx) Recommendations for Clinical Use of Mavacamten.
Clin Pharmacol Ther
November 2024
Laboratoire de Pharmacologie et Toxicologie NeuroCardiovasculaire, UR7296, Hopitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France.
Mavacamten, the first drug in the class of β-cardiac myosin modulator, is used for the treatment of patients with hypertrophic cardiomyopathy. This orally administered drug demonstrates wide interpatient variability in pharmacokinetics parameters, due in part to variant CYP2C19 alleles. Individuals who are CYP2C19 poor metabolizers have increased exposure and are at increased risk of reduced cardiac hypercontractility.
View Article and Find Full Text PDFTardive seizure after electroconvulsive therapy: Prevalence and associated factors.
Encephale
November 2024
University of Tunis El Manar, Faculty of Medicine of Tunis, Department of Psychiatry D, Razi Hospital, Manouba, Tunisia.
Article Synopsis
- Tardive seizures are rare, spontaneous seizures that can occur after electroconvulsive therapy (ECT), potentially leading to severe complications like status epilepticus, and the risk factors and management are not well-defined.
- This study aimed to explore the prevalence of tardive seizures in patients undergoing ECT at Razi Hospital over seven years and to identify factors linked to this occurrence.
- The retrospective analysis included 1,931 ECT sessions from 157 patients, revealing a 4.45% incidence of tardive seizures among patients and a prevalence rate of 0.57% for individual sessions.
Plasma levels and diagnostic utility of VEGF, MMP-9 and TIMP-2 in the diagnosis of psoriasis forms.
Growth Factors
November 2024
Laboratory of Biochemistry, La Rabta Hospital Tunis and LR99ES11, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia.
Article Synopsis
- Psoriasis is a common autoimmune skin disease, but its exact cause is still unclear; this study explores whether specific biomarkers can indicate the presence and severity of the condition.
- The research focuses on the relationship between serum levels of VEGF, MMP-9, and TIMP-2 in 115 psoriatic patients compared to 51 controls, using ELISA methods for measurement.
- Findings show that while VEGF has low effectiveness in distinguishing between psoriasis variants, the combination of TIMP-2 and inflammation Z-score significantly improves discriminative power, highlighting the role of inflammation and tissue damage in the disease's progression.
Neglected knee swelling: A case report of massive synovial chondromatosis.
Int J Surg Case Rep
December 2024
University of Tunis El Manar, Faculty of Medicine of Tunis, 1007, Tunisia; Department of Orthopedic Surgery, Hospital Mongi Slim, La Marsa, Tunisia.
Article Synopsis
- * A case presented involved a 68-year-old man who underwent surgery to remove a large mass in his knee caused by SC, which was confirmed through histological examination.
- * Early diagnosis and timely surgical intervention are crucial in managing SC to prevent complications, while vigilance is needed for potential malignant transformation in resistant cases.
Optimizing makespan and resource utilization in cloud computing environment via evolutionary scheduling approach.
PLoS One
November 2024
Department of Mathematics and Statistics, College of Science, Taif University, Taif, Saudi Arabia.
As a new computing resources distribution platform, cloud technology greatly influenced society with the conception of on-demand resource usage through virtualization technology. Virtualization technology allows physical resource usage in a way that will enable multiple end-users to have similar hardware infrastructure. In the cloud, many challenges exist on the provider side due to the expectations of clients.
View Article and Find Full Text PDFA large gastric inflammatory fibroid polyp revealed by an upper gastrointestinal bleeding: a case report.
Future Sci OA
December 2024
Department of Gastroenterology, Mohamed Taher Maamouri Hospital, Nabeul, Tunisia.
Article Synopsis
- - Inflammatory fibroid polyps (IFPs) are uncommon lesions found in the stomach, making up just 0.1% of gastric polyps, and often show no symptoms.
- - When symptoms do occur, they can include abdominal pain and gastrointestinal bleeding, particularly if the polyp becomes ulcerated.
- - A case study is presented involving a 72-year-old woman with a 35mm IFP in the prepyloric region, which was discovered after she experienced upper gastrointestinal bleeding and epigastric pain, leading to an endoscopic resection.
Deciphering the Resistome and Mobiolme of an Avian-Associated ST249 Clone that Acquired Vancomycin Resistance Isolated from Neutropenic Patient in Tunisia.
Microb Drug Resist
December 2024
Laboratory Ward, National Bone Marrow Transplant Center, Tunis, Tunisia.
Article Synopsis
- - The study identified the first vancomycin-resistant Enterococcus (VREfs) strain in Tunisia from an 8-year-old patient with bone marrow issues, using whole-genome sequencing (WGS) after isolating it during a hospital stay.
- - The strain showed significant resistance levels, with minimum inhibitory concentrations of vancomycin >256 mg/L and teicoplanin at 16 mg/L, and was classified as the ST249 clone typically found in avian sources.
- - This report highlights a novel case where an initially vancomycin-susceptible strain acquired resistance via a plasmid that carried a transposon, aided by specific genetic mechanisms related to conjugation and CRISPR interference
Pulmonary actinomycosis complicating COVID-19 pneumonia in an immunocompetent patient: a case report.
Future Sci OA
December 2024
Pulmonology Department, Mohamed Taher Maamouri University Hospital Nabeul University of Tunis El Manar, Nabeul, Tunisia.
Article Synopsis
- - A case study reports a 48-year-old male smoker who developed pyopneumothorax after experiencing pneumonia caused by COVID-19, requiring oxygen support and antibiotic treatment.
- - After initial recovery, he experienced hemoptysis, leading to a diagnosis of actinomycosis through endoscopic biopsy histopathology.
- - The patient responded well to prolonged antibiotic therapy with amoxicillin, highlighting the need to consider pulmonary actinomycosis in patients displaying lasting respiratory symptoms post-COVID-19.