Single but Not Combined In Vitro Exposure to Bisphenol A and Nanoplastics Affects the Cholinergic Function of the Ascidian .

Nanoplastics are known to represent a threat to marine ecosystems. Their combination with other contaminants of emerging concerns (CECs) may amplify ecotoxic effects, with unknown impacts on marine biodiversity. This study investigates the effects, single and combined, of bisphenol A (BPA)-one of the most hazardous CECs-and polystyrene nanoparticles (PS NPs)-as a proxy for nanoplastics, being among the most commonly found asmarine debris-on cholinesterase (ChE) activities of the ascidian .

Effect of Digoxin vs Beta-Blockers on Left Atrial Strain for Heart Rate-Controlled Atrial Fibrillation: The DIGOBET-AF Randomized Clinical Trial.

Unlabelled: BACKGROUND AND OBJECTIVE: Left atrial strain (LAS) has prognostic value in patients with atrial fibrillation (AF). Consequently, therapies that improve LAS may help reduce AF-related adverse cardiac events. We aimed to compare how digoxin and bisoprolol modulate LAS in patients with AF being treated with rate control.

Laser-ablated graphene electrodes modified with redox melanin-like film for redox capacitive sensing via the scavenging of nitrite ions.

Improper use and harmful effects of nitrite ions pose a significant risk to human health. To address this concern, the use of carbon-based materials for electrochemical sensing is regarded as one of the most promising detection tools for ensuring the quality of drinking water and food products. In this context, we developed laser-ablated graphene electrodes (LAGEs) by direct laser scribing on a polyimide substrate, which were subsequently modified by electrochemical deposition of a redox-active melanin-like film (MeLF/LAGEs).

Potential physiological tolerance mechanisms in faba bean to spp. parasitism.

spp. are root parasitic plants that cause severe yield losses in faba bean ( L.).

Alleviation of drought stress in tomato by foliar application of seafood waste extract.

To manage the adverse effects of garbage pollution and avoid using chemicals, a natural extract of seafood shells was obtained and explored for its beneficial role. Physical characterization highlighted that its active compounds correspond to chitin and its derivative, chitosan. The ability of the extracted biostimulant to foster tomato tolerance was tested on drought-stressed plants.

Full Circle: When HSFs bring the heat-mapping the transcriptional circuitries of HSF-type regulators in .

Heat shock factor (HSF)-type regulators are stress-responsive transcription factors widely distributed among eukaryotes, including fungi. They carry a four-stranded winged helix-turn-helix DNA-binding domain considered as the signature domain for HSFs. The genome of the opportunistic yeast encodes four HSF members, namely, Sfl1, Sfl2, Skn7, and the essential regulator, Hsf1.

Ramadan diurnal intermittent fasting in patients with diabetes: assessment of knowledge, practices, risk of complications, and impact of pre-ramadan education.

Objectives: Evaluate diabetic patients' knowledge, practices, and the prevalence of complications during Ramadan fasting (RF) before and after an education program.

Methods: We conducted a prospective study including 140 consecutive diabetic patients (DP) who intended to observe RF in 2023. Patients underwent a questionnaire and received pre-Ramadan education (PRE) according to the IDF-DAR 2021 recommendations.

Rapid detection of SARS-CoV-2 RNA using a one-step fast multiplex RT-PCR coupled to lateral flow immunoassay.

Background: The COVID-19 has put emphasis on pivotal needs for diagnosis and surveillance worldwide, with the subsequent shortage of diagnostic reagents and kits. Therefore, it has become strategic for the countries to access diagnostics, expand testing capacity, and develop their own diagnostic capabilities and alternative rapid accurate nucleic acid diagnostics that are at lower costs. Here, we propose a visual SARS-CoV-2 detection using a one-step fast multiplex reverse transcription-PCR (RT-PCR) amplification coupled to lateral flow immunoassay detection on a PCRD device (Abingdon Health, UK).

Associations of HLA-G 3'UTR polymorphisms and increased HLA-G expression with gastric cancer susceptibility and prognosis.

Background: Gastric cancer (GC) remains a serious health concern and is characterized by a multifactorial etiology involving both genetic and epigenetic factors. The aim of the current study was to examine the relationship between Human leukocyte antigen (HLA)-G 3'UTR polymorphisms and the expression of HLA-G in both tumor tissues and plasma samples from patients with GC in the Tunisian population.

Methods: HLA-G 3'UTR polymorphisms (14pb Insertion/deletion and + 3142C/G) were identified by polymerase chain reaction (PCR) or Sanger sequencing.

Voice recognition enhancement by genetic algorithm.

This research paper investigates the application of Genetic Algorithms (GA) in optimizing Artificial Neural Networks (ANN) for phoneme recognition. The study examines the formalism of GA, their parameters, and operators, and describes the genetic strategy adopted for phoneme recognition using the TIMIT sound database. The paper presents the outcomes of experiments conducted on the phonemes of the test base and the DR1 dialect learning base of the TIMIT base, and compares the recognition rates obtained by learning and testing with those guided by Self-Organizing Map (SOM) experiments.

One Receptor Show: Evaluation of Feature Extraction Methods for a Single Gas Sensor Based on α-Tocopherol-Substituted Zinc Phthalocyanine.

A consistent part of gas sensor research activities aims to improve sensing performances by synthesizing new sensing materials, improving the selection of elements in arrays, and optimizing the feature extraction and classification algorithms. This paper combines most of these aspects to confer selectivity to a low-selectivity sensor by using feature extraction algorithms applied to the sensor response kinetics. Several algorithms were employed to represent the kinetic behavior of the sensor response during the adsorption and desorption phases.

A new genus and a new species of microcotylids (Polyopisthocotyla, Platyhelminthes), gill parasite of the pink dentex (Teleostei, Sparidae) off Tunisia and notes on Polyopisthocotyla and Monopisthocotyla from spp.

The study of the polyopisthocotylan parasites of marine fishes in the western Mediterranean is carried on using an integrative approach combining morphology and DNA barcodes. n. gen.

Retraction of biomedical publications with Tunisian affiliation: causes, characteristics, and legislation regarding breaches of scientific integrity.

Introduction: breaches of research integrity have risen during these years. Tunisia´s stance regarding scientific integrity remains unknown. The aim of our study was to identify the reasons for the retraction of Tunisia-affiliated publications in the biomedical field, to describe the characteristics of these retractions, and to assess the position of Tunisian legislation regarding breaches of research integrity.

Acantholytic Dyskeratotic Acanthoma of the Nail Revealed by a Longitudinal Erythronychia.

Introduction: Focal acantholytic dyskeratosis is a distinctive histological pattern first described by Ackerman in 1972, consisting of focal suprabasal clefts in the epidermis and dyskeratotic cells at all levels of the epidermis with hyperkeratosis and parakeratosis. The first case of subungual acantholytic dyskeratosis acanthoma (ADA) was reported in 1990. This subungual variant is a very rare entity.

Sarcoidosis in north African people: about 35 cases.

Background And Aim: Sarcoidosis is a systemic disease of unknown cause characterized by the formation of non-caseating granulomatous inflammation in various organs, mainly  lungs and intrathoracic lymph nodes. Its clinical and paraclinical presentation can vary from mild to life-threatening. Our objective is to study the clinical, paraclinical and evolution profile of mediastino-pulmonary sarcoidosis.

Dermoscopy of Lichen Planus Pigmentosus and Histopathological Correlation: A Case Series.

Introduction: Lichen planus pigmentosus (LPP) is an acquired pigmentary disorder affecting the dark-skinned population. There is a wide range of differentials, with substantial clinicopathological overlap. Dermoscopy may contribute to the better characterization of this dermatosis.

Pre-sacral glomangioma: a rare localization of glomus tumors: case report.

Introduction And Importance: Deep-located glomangiomas are rarely reported. Because of their scarcity, treatment strategy is hard to establish. Herein, the authors report the first case to our knowledge of pre-sacral glomangioma.

Appendiceal diverticulitis: A rare case report highlighting diagnostic challenges and complication risks.

Introduction And Importance: Diverticular disease of the appendix is a rare condition often mistaken for acute appendicitis, with most cases diagnosed incidentally during histopathology, underscoring the importance of comprehensive pathological evaluation for accurate diagnosis.

Case Presentation: A 34-year-old male presented with one day of periumbilical pain migrating to the right iliac fossa, without vomiting or bowel changes. Clinical examination revealed tenderness in the RIF.