4 results match your criteria: "University of Traditional Chinese Medicine in Shanghai[Affiliation]"

Breast cancer (BRCA) is the most common malignancies worldwide with increasing rate. Dolichol phosphate mannose synthase (DPMS) is a critical mannosyltransferase involved in the posttranslational modification of proteins. At present, there is limited knowledge regarding the function of DPMS in breast cancer.

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Cadmium, a common metal, is an environmental contaminant that is hepatotoxic and immunotoxic. Cadmium exposure may affect hepatitis B immunity. The purpose of this study was to assess the association between cadmium exposure and hepatitis B serology in the US population and to develop a model to predict susceptibility of hepatitis B.

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Aims. To investigate the anticolorectal cancer (CRC) effects of Bufalin, a bioactive polyhydroxysteroid from Venenum Bufonis, using HCT116 human CRC cell and an established orthotopic xenograft model in mice, and to explore the mechanisms of action. Material and Methods.

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Article Synopsis
  • The study focused on the insulin-like growth factor 2 (IGF2) gene and its loss of imprinting (LOI) in 90 gastric cancer patients compared to 90 non-cancer controls.
  • IGF2 LOI was found in 48.5% of primary tumor tissues and was associated with advanced stage gastric tumors but did not significantly impact survival rates.
  • The research suggests that LOI of IGF2 may contribute to gastric cancer development by increasing IGF2 expression, indicating its potential as a clinical marker for identifying individuals at higher risk for the disease.
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