Effects of coastal protection structures in controlling erosion and livelihoods.

The fiscal and social cost of ameliorating the impact of coastal erosion resulting from climate change is an increasing burden for coastal states, and in developing nations the physical interventions implemented may present a double agony - increasing debt levels and potentially obstructing livelihoods in the rural coasts. Against this background, this study was conducted to explore the impact of hard-engineered coastal protection on coastal vulnerability and community livelihoods in Ghana using a combination of Unmanned Aerial Vehicles (UAV), geographic information system tools and social survey. Shoreline change analysis by the application of the Digital Shoreline Analysis System (DSAS) with aerial photographs from 2005 to 2022 reveals an average statistical rate of change of -1 m/year in shoreline erosion of the beaches.

Competition between transcription and loop extrusion modulates promoter and enhancer dynamics.

The spatiotemporal configuration of genes with distal regulatory elements, and the impact of chromatin mobility on transcription, remain unclear. Loop extrusion is an attractive model for bringing genetic elements together, but how this functionally interacts with transcription is also largely unknown. We combine live tracking of genomic loci and nascent transcripts with molecular dynamics simulations to assess the spatiotemporal arrangement of the gene and its enhancer, in response to a battery of perturbations.

Ribosome biogenesis and the cellular energy economy.

Cell growth relies upon the ability to produce new proteins, which requires energy and chemical precursors, and an adequate supply of the molecular machines for protein synthesis - ribosomes. Although not widely appreciated, ribosomes are remarkably abundant in all cells. For example, in a rapidly growing yeast cell there are ∼2-4 x 10 ribosomes, produced and exported to the cytoplasm at a rate of ∼2,000-4,000 per minute, with ribosomal proteins making up ∼50% of total cellular protein number and ∼30% of cellular protein mass.

Identifying key questions in the ecology and evolution of cancer.

The application of evolutionary and ecological principles to cancer prevention and treatment, as well as recognizing cancer as a selection force in nature, has gained impetus over the last 50 years. Following the initial theoretical approaches that combined knowledge from interdisciplinary fields, it became clear that using the eco-evolutionary framework is of key importance to understand cancer. We are now at a pivotal point where accumulating evidence starts to steer the future directions of the discipline and allows us to underpin the key challenges that remain to be addressed.

Disentangling the Microphysical Effects of Fire Particles on Convective Clouds Through A Case Study.

Aerosol emissions from forest fires may impact cloud droplet activation through an increase in particle number concentrations ("the number effect") and also through a decrease in the hygroscopicity of the entire aerosol population ("the hygroscopicity effect") when fully internal mixing is assumed in models. This study investigated these effects of fire particles on the properties of simulated deep convective clouds (DCCs), using cloud-resolving simulations with the Weather Research and Forecasting model coupled with Chemistry for a case study in a partly idealized setting. We found that the magnitude of the hygroscopicity effect was in some cases strong enough to entirely offset the number/size effect, in terms of its influence on modeled droplet and ice crystal concentrations.

Increased phantom recollection after sleep.

Sleep is known to benefit memory consolidation, but its effect on false memory is less clear. We applied the simplified conjoint recognition paradigm to investigate how sleep affects the cognitive processes behind correct or false recognition, according to fuzzy-trace theory, and measured the retrieval of verbatim traces, retrieval of gist traces, and phantom recollection. Participants studied 24 lists of semantically related words lacking the strongest common associate or theme word.

False memories in obstructive sleep apnoea syndrome: evidence from the divided attention paradigm at encoding or retrieval.

Patients with obstructive sleep apnoea syndrome (OSAS) exhibit impaired retrieval of item-specific information, increasing their propensity to generate false recognitions. The present study investigated the effect of OSAS on false recognition, using a divided-attention paradigm to examine whether reducing the availability of attentional resources during encoding or retrieval in healthy participants mimics the effect of OSAS. We tested four groups of participants, using the Deese - Roediger - McDermott paradigm: patients with OSAS and controls, either under full attention or under divided attention at encoding or retrieval.

Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics.

A key feature of Notch signaling is that it directs immediate changes in transcription via the DNA-binding factor CSL, switching it from repression to activation. How Notch generates both a sensitive and accurate response-in the absence of any amplification step-remains to be elucidated. To address this question, we developed real-time analysis of CSL dynamics including single-molecule tracking in vivo.

Coastal ocean and shelf-sea biogeochemical cycling of trace elements and isotopes: lessons learned from GEOTRACES.

Continental shelves and shelf seas play a central role in the global carbon cycle. However, their importance with respect to trace element and isotope (TEI) inputs to ocean basins is less well understood. Here, we present major findings on shelf TEI biogeochemistry from the GEOTRACES programme as well as a proof of concept for a new method to estimate shelf TEI fluxes.

WMO World Record Lightning Extremes: Longest Reported Flash Distance and Longest Reported Flash Duration.

A World Meteorological Organization weather and climate extremes committee has judged that the world's longest reported distance for a single lightning flash occurred with a horizontal distance of 321 km (199.5 mi) over Oklahoma in 2007, while the world's longest reported duration for a single lightning flash is an event that lasted continuously for 7.74 seconds over southern France in 2012.

mtDNA variation in the Buryat population of the Barguzin Valley: New insights into the micro-evolutionary history of the Baikal area.

Background: Southern Siberian populations, including the Buryat, have been of great interest in investigating the exchanges between Eastern and Western Eurasia and understanding the peopling of Siberia and the New World.

Aim: Previous studies mainly employed a phylogenetic approach, and thus used pooled samples to detect a maximum of variability. As different sampling strategies may result in different pictures of a population's evolutionary history, we proposed in this study to focus on a local Buryat population selected on the basis of geographical, archaeological and ethno-historical data.