2 results match your criteria: "University of Toronto Faculty of Medicine Toronto[Affiliation]"

A computerized tablet with visual feedback of hand position for functional magnetic resonance imaging.

Front Hum Neurosci

April 2015

Graham Laboratory, Physical Sciences Platform, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre Toronto, ON, Canada ; Department of Medical Biophysics, University of Toronto Faculty of Medicine Toronto, ON, Canada ; Heart and Stroke Foundation Canadian Partnership for Stroke Recovery Canada.

Neuropsychological tests behavioral tasks that very commonly involve handwriting and drawing are widely used in the clinic to detect abnormal brain function. Functional magnetic resonance imaging (fMRI) may be useful in increasing the specificity of such tests. However, performing complex pen-and-paper tests during fMRI involves engineering challenges.

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We studied the effect of brefeldin A, which inhibits the intracellular trafficking of membrane proteins from the cytosolic pool to the cell surface, on terbutaline (a beta2-specific adrenergic agonist)-induced alterations in ion transport by primary monolayer cultures of fetal rat distal lung epithelium. The amiloride-sensitive short circuit current (Isc) increased 2.5-fold 50 min after application of terbutaline (10 microM) from basolateral side; this response was abolished by pretreatment with brefeldin A (1 microg/ml).

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