1 results match your criteria: "University of Toronto 160 College Street Toronto ON Canada M5S 3E1.[Affiliation]"
Specific targeting of the deubiquitinase and E3 ligase families with engineered ubiquitin variants.
Bioeng Transl Med
March 2017
Banting and Best Dept. of Medical Research and the Dept. of Molecular Genetics Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto 160 College Street Toronto ON Canada M5S 3E1.
The ubiquitin proteasome system (UPS) has garnered much attention due to its potential for the development of therapeutics. Following a successful clinical application of general proteasome inhibitors much effort has been devoted to targeting individual UPS components including E3 enzymes and deubiquitinases that control specificity of ubiquitination. Our group has developed a novel approach for targeting the UPS proteins using engineered ubiquitin variants (Ubvs).
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