4 results match your criteria: "University of ToledoToledo[Affiliation]"
HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies.
Front Pharmacol
August 2017
Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of ToledoToledo, OH, United States.
This study was designed to determine the mechanisms by which the novel silybin derivative, (E)-3-(3-(benzyloxy) phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one ( or ), produces its anticancer efficacy in ovarian cancer cells. Compound induced apoptosis in ovarian cancer cells in a time-dependent manner by significantly upregulating the expression of Bax and Bak and downregulating the expression of Bcl-2. Interestingly, induced the cleavage of Bax p21 into its more efficacious cleaved form, Bax p18.
View Article and Find Full Text PDFEffects of Ceftriaxone on Glial Glutamate Transporters in Wistar Rats Administered Sequential Ethanol and Methamphetamine.
Front Neurosci
September 2016
Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of ToledoToledo, OH, USA; Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of ToledoToledo, OH, USA.
Methamphetamine (METH) is one of the psychostimulants that is co-abused with ethanol. Repeated exposure to high dose of METH has been shown to cause increases in extracellular glutamate concentration. We have recently reported that ethanol exposure can also increase the extracellular glutamate concentration and downregulate the expression of glutamate transporter subtype 1 (GLT-1).
View Article and Find Full Text PDFEffects of Benzodiazepines on Acinar and Myoepithelial Cells.
Front Pharmacol
July 2016
Department of Pharmacology, College of Pharmacy and Pharmaceutical, The University of ToledoToledo, OH, US; Program of Post-Graduation, Department of Pharmacology, School of Dentistry, Health and Bioscience School, Pontifical Catholic University of ParanáCuritiba, Brazil.
Article Synopsis
- Benzodiazepines (BZDs) can lead to decreased saliva production by affecting the structure of parotid glands, resulting in changes in cell types like acinar, ductal, and myoepithelial cells.
- The study involved 90 male Wistar rats, with different groups receiving varying treatments of BZDs or pilocarpine over 30 to 60 days to observe effects on cell expression.
- Results indicated that lorazepam increased calponin expression in myoepithelial cells, while midazolam combined with pilocarpine enhanced cell proliferation but reduced calponin levels, suggesting that myoepithelial cells might be particularly affected by BZDs.