6,740 results match your criteria: "University of The Ryukyus[Affiliation]"
Biomed Eng Online
December 2024
ORTHOREBIRTH Co., Ltd., Yokohama, Japan.
Background: A biodegradable nonwoven fabric that can be used to extract adipose-derived stem cells (ADSCs) from adipose tissue slices was developed, which were cultured rapidly without enzymatic treatment. The extracted and cultured ADSCs remain on the nonwoven fabric and form a thick cell sheet. The aim was to use the thick cell sheet as a treatment by transplanting it into the living body.
View Article and Find Full Text PDFJ Gastroenterol
December 2024
Department of Gastroenterological Endoscopy, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.
Background: Despite accumulating evidence and recommendations for management of colonic diverticular bleeding (CDB), the changes in its clinical management and outcomes remain unknown.
Methods: We performed a retrospective tendency analysis on a biennial basis, a propensity score-matched cohort study between the first and latter half groups, and mediation analyses to compare the diagnostic and treatment methods between January 2010 and December 2019 (CODE BLUE-J Study).
Results: A total of 6575 patients with CDB were included.
Nat Prod Res
December 2024
Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Japan.
One new acyclic norditerpenoid, lamellodysideol () was isolated from the Indonesian marine sponge together with known phytol (). The structure of was determined on the basis of spectral evidence and by comparison with known related molecules including optical rotation data. The relative configurations of and were proposed using quantum chemical calculation of NMR chemical shifts at DFT levels.
View Article and Find Full Text PDFDev Growth Differ
December 2024
Graduate School of Medical Sciences, Tottori University Yonago, Tottori, Japan.
5'Hox genes regulate pattern formation along the axes of the limb. Previously, we showed that Hoxa13/Hoxd13 double-mutant newts lacked all digits of the forelimbs during development and regeneration, showing that newt Hox13 is necessary for digit formation in development and regeneration. In addition, we found another unique phenotype.
View Article and Find Full Text PDFAm J Pathol
December 2024
Department of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Japan.
Periodontitis was reported to be associated with aspiration pneumonia. However, the relationship between periodontitis and aspiration pneumonia remains unclear. This study investigated the virulence factor of Porphyromonas gingivalis, which exacerbates aspiration pneumonia, and the role of IL-35, an inhibitory heterodimeric cytokine of EBI3 and p35, in aspiration pneumonia using Ebi3 knockout (KO) mice.
View Article and Find Full Text PDFJ Dermatol
December 2024
Department of Dermatology, University of the Ryukyus Graduate School of Medicine, Okinawa, Japan.
Hypertens Res
December 2024
Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
Home blood pressure (BP) measurement is widely used, and home BP plays a central role in hypertension management in clinical practice in Japan. We updated the systematic review to determine whether home BP-based antihypertensive treatment is superior to office BP-based treatment in improving clinical outcomes, including BP levels, in adult patients with essential hypertension. A literature search identified 14 randomized controlled trials (RCTs).
View Article and Find Full Text PDFGlycoconj J
December 2024
Department of Urology, University of the Ryukyus Graduate School of Medicine, 207 Uehara, Nishihara, Nakagami-gun, Okinawa, 903-0215, Japan.
Stage-specific embryonic antigen-4 (SSEA-4) is a developmentally regulated antigen, while expression level of SSEA-4 and / or its synthase ST3GAL2 is associated with prognosis in various malignancies. We have reported a prominent increase of SSEA-4 in castration-resistant prostate cancer (CRPC) and its negative correlation with the androgen receptor (AR). Meanwhile, loss of AR has increased to approximately 30% with the growing use of androgen receptor signaling inhibitor for metastatic CRPC (mCRPC).
View Article and Find Full Text PDFZool Stud
September 2024
Biodiversity Research Center, Academia Sinica, Taipei 115, Taiwan. E-mail: (Tang).
Rützler & Muzik, 1993 is a poriferan species that competes with corals and is known as a coral-killing sponge. However, limited information is available on its biology, including morphological traits. This study aims to examine the arrangement and development of spicules in various body parts of the sponge, including settled larvae.
View Article and Find Full Text PDFTrop Med Health
December 2024
Department of Global Health, Graduate School of Health Sciences, University of the Ryukyus, Nishihara, Japan.
Introduction: The COVID-19 pandemic has severely impacted the health and education of learners globally. However, there is a lack of information on enablers and barriers to the implementation of comprehensive school health policies during the pandemic.
Methods: This study utilized a case study design, and was conducted in the Division of City Schools of Navotas.
Respir Investig
December 2024
Department of Pulmonology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Background: No previous studies have compared respiratory clinics and respiratory specialized facilities regarding causative diseases for bloody sputum and hemoptysis in Japan.
Methods: We retrospectively compared causative diseases for bloody sputum and hemoptysis between 3 respiratory clinics (clinic group) and 7 departments of respiratory medicine at hospitals (hospital group) in Japan.
Results: We collected data from 231 patients (median age, 51 years; age range, 24-96 years; 109 men (47.
J Med Case Rep
December 2024
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nakagami, Nishihara, Okinawa, 903-0215, Japan.
Background: Adult hypophosphatasia is an uncommon inherited disorder of mineral homeostasis affecting bone. It arises from mutations within the Alkaline Phosphatase, Biomineralization Associated (ALPL) gene, which encodes tissue-nonspecific alkaline phosphatase. Because of its low prevalence and non-specific clinical manifestations, underdiagnosis and misdiagnosis are frequent, particularly in Asian populations.
View Article and Find Full Text PDFPlant Mol Biol
December 2024
Department of Gene Function and Phenomics, National Institute of Genetics, Shizuoka, 411-8540, Japan.
Inorganic polyphosphate (polyP) is a linear polymer of phosphate that plays various roles in cells, including in phosphate and metal homeostasis. Homologs of the vacuolar transporter chaperone 4 (VTC4), catalyzing polyP synthesis in many eukaryotes, are absent in red algae, which are among the earliest divergent plant lineages. We identified homologs of polyphosphate kinase 1 (PPK1), a conserved polyP synthase in bacteria, in 42 eukaryotic genomes, including 31 species detected in this study and 12 species of red algae.
View Article and Find Full Text PDFZookeys
December 2024
The Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.
Species of the genus Cuvier, 1829 (Pempheridae) from Japan and Taiwan are taxonomically reviewed based on morphology supported by molecular phylogenetic analysis. Ten species are recognized from these countries: Bleeker, 1855, Koeda & Motomura, 2017, Döderlein, 1883, Jordan & Evermann, 1902, Cuvier, 1831, Jordan & Hubbs, 1925, Bleeker, 1877, Koeda, Yoshino & Tachihara, 2013, Cuvier, 1831, Tominaga, 1963. Nine of them are distributed in Japan, and five of them in Taiwan.
View Article and Find Full Text PDFStem Cell Res Ther
December 2024
Department of Orthopedic Surgery, Kanazawa Medical University, Kahoku, Ishikawa, 920-0293, Japan.
Background: Adipose-derived stem cells (ADSCs) are widely used in the field of regenerative medicine because of their various functions, including anti-inflammatory effects. ADSCs are considered to exert their anti-inflammatory effects by secreting anti-inflammatory cytokines and extracellular vesicles. Although recent studies have reported that metabolites have a variety of physiological activities, whether those secreted by ADSCs have anti-inflammatory properties remains unclear.
View Article and Find Full Text PDFMar Pollut Bull
December 2024
School of Marine Biosciences, Kitasato University, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa 252-0373, Japan.
Nitrogen's impact on corals has been widely studied, but the role of phosphate is often overlooked due to its low concentrations in seawater. Previous studies have suggested that phosphate can penetrate intercellular spaces to reach the extracellular calcifying medium (ECM), where it adsorbs onto skeletal surfaces and disrupts calcium carbonate crystallization, thereby inhibiting skeletal growth. Based on this mechanism, we hypothesized that skeletal growth inhibition depends not only on phosphate concentration but also on total phosphate load (flow volume × concentration).
View Article and Find Full Text PDFObstet Gynecol Sci
December 2024
Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan.
Objective: To evaluate the diagnostic utility and limitations of routine p16 and Ki-67 immunohistochemistry (IHC) in detecting high-grade squamous intraepithelial lesions (HSILs) in the uterine cervix.
Methods: We reviewed 2,061 cervical biopsy records, including 271 morphologically indeterminate squamous lesions, evaluated using p16/Ki-67 IHC for HSIL detection or exclusion. HSIL was diagnosed based on p16 positivity and a high Ki-67 labeling index (Ki-LI).
Clin Biochem
December 2024
Department of Hospital Pharmacy, Nagasaki University Hospital, Nagasaki, Japan; Department of Molecular Pathochemistry, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. Electronic address:
Background: The factors contributing to the development of severe coronavirus disease 2019 (COVID-19) following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain unclear. Although the presence of immune complexes (ICs), formed between antibodies and their antigens, has been linked to COVID-19 severity, their role requires further investigation, and the antigens within these ICs are yet to be characterized.
Method: Here, a C1q enzyme-liked immunosorbent assay and immune complexome analysis were used to determine IC concentrations and characterize IC antigens, respectively, in the sera of 64 unvaccinated COVID-19 patients with PCR-confirmed SARS-CoV-2 infection, enrolled at seven participating centers in 2020.
Leuk Res
December 2024
Laboratory of Hemato-Immunology, Graduate School of Health Sciences, University of the Ryukyus, Nishihara, Japan.
Leuk Lymphoma
December 2024
Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.
Nrf2 plays a critical role in regulating cytoprotective transcriptional responses and glucose metabolism while also preventing inflammation-induced carcinogenesis. However, Nrf2 can paradoxically promote carcinogenesis. Here, we aimed to elucidate the role of Nrf2 in ATL associated with HTLV-1.
View Article and Find Full Text PDFJ Fish Biol
December 2024
Tropical Biosphere Research Center, University of the Ryukyus, Okinawa, Japan.
Here, we provide the first in situ observations of foraging habitats of Chaetodon daedalma, which is endemic to the subtropical north-west Pacific. Overall, 62.4% of bites were from the substratum, 30.
View Article and Find Full Text PDFJ Clin Med
November 2024
Department of Pediatric Dentistry, Asahi University School of Dentistry, Gifu 501-0296, Japan.
Dental pulp (DP) is a connective tissue composed of various cell types, including fibroblasts, neurons, adipocytes, endothelial cells, and odontoblasts. It contains a rich supply of pluripotent stem cells, making it an important resource for cell-based regenerative medicine. However, current stem cell collection methods rely heavily on the enzymatic digestion of dissected DP tissue to isolate and propagate primary cells, which often results in low recovery rates and reduced cell survival, particularly from deciduous teeth.
View Article and Find Full Text PDFHeart Vessels
December 2024
Department of Cardiovascular Medicine, Nephrology, and Neurology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara Town, Okinawa, Japan.
J Arrhythm
December 2024
Department of Clinical Research and Management, Graduate School of Medicine University of the Ryukyus Nishihara Okinawa Japan.
Background: Direct oral anticoagulants (DOACs) are preferred for stroke prevention in nonvalvular atrial fibrillation (NVAF); however, warfarin is still used. This study examined why physicians may choose warfarin over DOACs and the associated safety outcomes in patients with NVAF.
Methods: We conducted a new-user, active-comparator cohort study in newly diagnosed patients with NVAF to assess safety outcomes after the introduction of DOACs in Japan.
J Atheroscler Thromb
December 2024
Division of Endocrinology, Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus.
A 59-year-old Japanese woman was referred for an extremely low level of circulating high-density lipoprotein cholesterol (HDL-C). The serum HDL-C level had long been within the normal range but suddenly decreased asymptomatically to 7 mg/dL. She had no typical symptoms associated with familial lecithin, cholesterol acyltransferase deficiency (FLD), including proteinuria, anemia, and corneal opacity.
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