638 results match your criteria: "University of Texas at Austin - Dell Medical School[Affiliation]"

Objective: Describe a student coproduced curriculum to lay the foundation for professional identity development (PID).

Methods: Occurring during the introductory course of medical school, the Grab Bag Activity (GBA) is coordinated by upper-level students to offer informal, self-selected activities sponsored by upper-level students or faculty for incoming first-year students. Various levels of relationship are fostered: student to peer, student to near-peer, and student to faculty.

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Background: Diagnostic test evaluation requires a reference standard. We describe an approach for creating a reference standard for acute infection using unrestricted adjudication and apply it to compare biomarker tools.

Methods: Adults and children with suspected acute infection enrolled in three prospective studies at emergency departments and urgent cares were included.

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Psychedelics in Psychiatry: Oh, What A Trip!

Am J Psychiatry

January 2025

Department of Psychiatry and Behavioral Sciences, Center for Psychedelic Research and Therapy, and Institute for Early Life Adversity Research, University of Texas at Austin Dell Medical School (Fonzo, Nemeroff); Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison (Kalin).

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MDMA and MDMA-Assisted Therapy.

Am J Psychiatry

January 2025

Directorate of Behavioral Health, Walter Reed National Military Medical Center, Bethesda, MD (Wolfgang); Departments of Psychiatry (Wolfgang) and Medical and Clinical Psychology (Gray), Uniformed Services University, Bethesda, MD; Departments of Psychiatry (Wolfgang, Krystal), Neuroscience (Krystal), and Psychology (Krystal), Yale University School of Medicine, New Haven, CT; Center for Psychedelic Research and Therapy, Department of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School (Fonzo, Nemeroff); Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, UCLA (Grzenda); Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham (Kraguljac); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, Stanford University and Veterans Affairs Palo Alto Health Care System, Palo Alto, CA (Rodriguez).

Article Synopsis
  • MDMA, also known as Ecstasy or Molly, has been used since the 1970s for both recreational and therapeutic purposes, with the FDA recognizing its potential for treating PTSD as a Breakthrough Therapy in 2017.
  • The effects of MDMA in therapeutic settings are distinct, promoting trust and self-compassion while allowing cognitive clarity, which differentiates it from other psychedelics.
  • Preliminary evidence indicates that MDMA-Assisted Therapy is effective, with 67%-71% of PTSD patients no longer meeting diagnostic criteria after treatment, significantly more than those receiving placebo therapy.
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Psilocybin: From Psychiatric Pariah to Perceived Panacea.

Am J Psychiatry

January 2025

Department of Psychiatry and Behavioral Sciences (Fonzo, Barksdale, Nemeroff) and Center for Psychedelic Research and Therapy (Fonzo, Nemeroff), University of Texas at Austin Dell Medical School, Austin; Institute for Early Life Adversity Research, University of Texas at Austin, Austin (Fonzo, Nemeroff); Department of Behavioral Health, Walter Reed National Military Medical Center, Bethesda, MD (Wolfgang); Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD (Wolfgang); Department of Psychiatry, Yale University School of Medicine, New Haven, CT (Wolfgang, Krystal); Butler Hospital, Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI (Carpenter); Department of Psychiatry and Behavioral Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham (Kraguljac); Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles (Grzenda); Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta (McDonald); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA (Rodriguez); Veterans Affairs Palo Alto Health Care System, Palo Alto, CA (Rodriguez).

Objective: The authors critically examine the evidence base for psilocybin administered with psychological support/therapy (PST) in the treatment of psychiatric disorders and offer practical recommendations to guide future research endeavors.

Methods: PubMed was searched for English-language articles from January 1998 to November 2023, using the search term "psilocybin." A total of 1,449 articles were identified and screened through titles and abstracts.

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Navigating the Surgical Pathway for Frail, Older Adults Undergoing Colorectal Surgery.

Clin Colon Rectal Surg

January 2025

Division of Colon and Rectal Surgery, Department of Surgery and Perioperative Care, University of Texas at Austin Dell Medical School, Austin, Texas.

Adults ≥ 65 years of age comprise nearly 20% of the U.S. population and over half of surgical patients.

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Objectives: Pre-exposure prophylaxis (PrEP) is a key biomedical intervention for ending the HIV epidemic in the United States, but its uptake is impeded by systemic barriers, including fragmented workflows and ineffective data coordination. This study aims to design PrEPLinker, a blockchain-based, client-centered platform to enhance care to address these challenges by improving care coordination and enabling clients to securely manage their identity and PrEP-related data.

Materials And Methods: Using Houston, Texas, as a use case, we conducted a needs assessment with PrEP collaborators to evaluate existing workflows and identify barriers in the PrEP care continuum.

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Unlabelled: This case is a rare presentation of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), where malignant pericardial effusion (MPE) served as the primary manifestation. A 58-year-old woman, post-breast implant removal, presented with pleuritic chest pain, fever, and chills. Clinical evaluation revealed jugular venous distention, muffled heart sounds, and hemodynamic instability.

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Despite global awareness of the impacts of climate change on human health, assessment of resident physicians' confidence in environmental health is limited. Lack of confidence in explaining environmental health topics can affect both patient education and advocacy efforts. To determine how confident resident physicians are in their environmental health training and their ability to explain climate health topics.

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Article Synopsis
  • Accurate intraoperative diagnosis of primary CNS lymphoma (PCNSL) is vital for surgical decisions but is challenging due to similar features with other CNS diseases; a new method combines stimulated Raman histology (SRH) with deep learning to improve this process.
  • The RapidLymphoma system uses a portable Raman microscope to create virtual images of tissue samples in under three minutes and employs a deep learning model trained on 54,000 images, allowing it to detect PCNSL and differentiate it from other conditions effectively.
  • In testing, RapidLymphoma achieved a high accuracy rate of 97.81%, performing better than traditional methods, and demonstrated its capability to identify specific histological features crucial for diagnosis, providing quick feedback
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Background/purpose: Childhood Sjögren disease (cSjD) is a rare disease. There are no widely accepted diagnostic or classification criteria for cSjD. To fill this gap, members from CARRA Sjogren Workgroup and the International cSjD Workgroup created a clinical diagnostic algorithm.

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Background: Caregivers of people living with dementia (PLWD) often experience burden based on their care recipients' symptoms of wandering, disorientation, and agitation.

Objective: To examine the utilization and perceived value of technology-based solutions for caregiving among caregivers of PLWD.

Methods: In collaboration with three Texas sites, PLWD and family caregiver dyads were recruited from clinical and community sites to assess the feasibility of a caregiving technology.

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Objectives: To measure physical activity in a cohort of children who survived greater than or equal to 3 days of invasive ventilation.

Design: Prospective cohort study (2018-2021).

Setting: Quaternary children's hospital PICU.

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Neurofibromatosis type 1 (NF1) is one of the most common genetic conditions. It can be inherited in an autosomal dominant manner, but almost half of cases occur de novo. NF1 is associated with café-au-lait macules, freckles in the inguinal and axillary region, neurofibromas, Lisch nodules of the iris or choroidal abnormalities, optic pathway gliomas, and distinctive bone anomalies.

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Background: Ayahuasca is an Amazonian brew with 5-HT-dependent psychedelic effects taken by religious groups globally. Recently, psychedelics have been shown to impair the formation of recollections (hippocampal-dependent episodic memory for specific details) and potentially distort memory while remembering. However, psychedelics spare or enhance the formation of familiarity-based memory (cortical-dependent feeling of knowing that a stimulus has been processed).

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Neurohospitalist Core Competencies.

Neurohospitalist

November 2024

Department of Neurology and Neurosciences, Stanford University School of Medicine, Stanford, CA, USA.

The Neurohospitalist Core Competencies comprise a set of competency-based learning objectives that encapsulate the knowledge, skills, and attitudes of neurohospitalitists who specialize in the care of hospitalized patients with neurologic conditions. These competencies serve to characterize the rapidly expanding field of neurohospitalist medicine. The 27 chapters are divided into 3 sections entitled: neurological conditions, clinical interventions and interpretation of ancillary studies, and neurohospitalist role in the healthcare system.

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As the population ages, the prevalence of cognitive impairment due to neurodegenerative diseases such as Alzheimer disease (AD) is expected to double in the United States to nearly 14 million over the next 40 years. AD and related dementias (ADRD) are a leading cause of morbidity and mortality and among the costliest to society. Although emerging biomedical interventions for ADRD focus on early stages and are currently limited to AD, care management can benefit patients with ADRD across the disease course.

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Chronic alcohol consumption exacerbates ischemia-associated skeletal muscle mitochondrial dysfunction in a murine model of peripheral artery disease.

Biochim Biophys Acta Mol Basis Dis

February 2025

Department of Public Health, Usha Kundu MD College of Health, University of West Florida, Pensacola, FL, USA; Department of Biology, Baylor University, Waco, TX, USA. Electronic address:

Article Synopsis
  • Peripheral artery disease (PAD) leads to muscle damage linked to mitochondrial dysfunction, and the study aims to understand how alcohol and a high-fat diet affect this condition in a mouse model.
  • Mice were placed on high-fat-sucrose (HFS) or low-fat-sucrose (LFS) diets and given ethanol to analyze its impact on oxidative stress and mitochondrial health after inducing limb ischemia.
  • Findings revealed that high-fat and alcohol consumption worsened mitochondrial issues in muscles, with reduced levels of the enzyme ALDH2 correlating with increased oxidative stress, suggesting ALDH2 may be a therapeutic target for PAD patients with unhealthy diets.
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Speech perception and language comprehension in primary progressive aphasia.

Cortex

December 2024

Department of Speech, Language, and Hearing Sciences, The University of Texas at Austin, Austin, TX, USA; Department of Neurology, The University of Texas at Austin Dell Medical School, Austin, TX, USA.

Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by progressive loss of speech and language. Although speech perception and language comprehension deficits are observed in individuals with PPA, these deficits have been understudied relative to production deficits. Recent work has examined receptive language processing at sublexical, lexical, and semantic levels in PPA; however, systematic investigation of these levels of processing within a single PPA cohort is lacking.

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Objective: This qualitative study aimed to analyse rectal cancer survivors' lived experiences to identify facilitators and barriers to support access.

Design: We conducted one-on-one semi-structured interviews and employed thematic analysis to identify key themes and insights.

Setting/participants: Participants included eight rectal cancer survivors and three caregivers recruited at Texas Colorectal Collaborative sites.

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Article Synopsis
  • The 2023 American Epilepsy Society Annual Course focused on the importance of timing in evaluating and treating epilepsy, especially for vulnerable populations and those facing health disparities.
  • The course covered a wide range of topics, including gaps in epilepsy care, behavioral health optimization, seizure forecasting, and treatment timing for various seizure types and conditions.
  • Key discussions included the role of neuromodulation versus surgery, strategies for autoimmune-associated epilepsy, dietary therapy, and leveraging new biomarkers in collaboration with neuropsychological outcomes.
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Objective: The population of adults with single-ventricle congenital heart disease (CHD) is growing. This study explores their lived experiences through an adult developmental psychology framework.

Methods: Individuals aged 18 and older with single-ventricle CHD participated in Experience Group sessions and 1:1 interviews.

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