5 results match your criteria: "University of Texas Health Sciences Center in San Antonio[Affiliation]"
Incident heart failure in chronic kidney disease: proteomics informs biology and risk stratification.
Eur Heart J
August 2024
Division of Cardiology, University of California San Francisco, San Francisco, CA, USA.
Background And Aims: Incident heart failure (HF) among individuals with chronic kidney disease (CKD) incurs hospitalizations that burden patients and health care systems. There are few preventative therapies, and the Pooled Cohort equations to Prevent Heart Failure (PCP-HF) perform poorly in the setting of CKD. New drug targets and better risk stratification are urgently needed.
View Article and Find Full Text PDFProteomics of CKD progression in the chronic renal insufficiency cohort.
Nat Commun
October 2023
Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA.
Article Synopsis
- This study investigates the link between 4638 plasma proteins and the risk of kidney failure in 3235 participants over a 10-year period, using data from the Chronic Renal Insufficiency Cohort Study.
- Researchers identify 100 proteins significantly associated with a 50% decline in kidney function, with a focus on pathways related to bone morphogenetic proteins and ephrin signaling.
- A developed risk model based on 65 proteins shows strong predictive ability for kidney failure, suggesting that modifiable protein markers could assist in creating treatments to slow chronic kidney disease progression.
Idasanutlin, an MDM2 antagonist, showed clinical activity and a rapid reduction in JAK2 V617F allele burden in patients with polycythemia vera (PV) in a phase 1 study. This open-label phase 2 study evaluated idasanutlin in patients with hydroxyurea (HU)-resistant/-intolerant PV, per the European LeukemiaNet criteria, and phlebotomy dependence; prior ruxolitinib exposure was permitted. Idasanutlin was administered once daily on days 1 through 5 of each 28-day cycle.
View Article and Find Full Text PDFCircumferential viscodilation of Schlemm's canal for open-angle glaucoma: ab-interno vs ab-externo canaloplasty with tensioning suture.
Clin Ophthalmol
December 2018
Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.
Purpose: To compare the efficacy of minimally invasive ab-interno canaloplasty (ABiC) vs ab-externo canaloplasty (CP) in reducing intraocular pressure (IOP) and glaucoma medication dependence.
Patients And Methods: This nonrandomized, retrospective, single-center, paired eye study assessed the 12-month outcomes of 12 patients with primary open-angle glaucoma who underwent ABiC in one eye and CP in the other eye, either as stand-alone procedures or combined with cataract extraction. Primary endpoints included mean IOP and number of glaucoma medications at 12 months postoperative.
Fibromyalgia syndrome: case-based learning.
CNS Spectr
October 2009
University Clinical Research Center, University of Texas Health Sciences Center in San Antonio, Texas, USA.