Testing neonate-infant membrane oxygenators with the University of Texas neonatal pulsatile cardiopulmonary bypass system in vitro.

Neurologic complications are already well documented after cardiopulmonary bypass (CPB) procedures in neonates and infants. Physiologic pulsatile flow CPB systems may be the alternative to the currently used steady-flow CPB circuits. In addition to the pulsatile pump, a membrane oxygenator should be chosen carefully, because only a few membrane oxygenators are suitable for physiologic pulsatile flow.

Twelve-hour canine heart preservation with a simple, portable hypothermic organ perfusion device.

Background: Cardiac transplantation is limited to an ischemic time of around 6 hours by available preservation solution and technique. Complex organ preservation devices have been developed that extend this time to 24 hours or more, but are clinically impractical. This study evaluates a portable oxygen-driven organ perfusion device weighing approximately 13.

A technique for separation of perfluorocarbons from blood used in cardiopulmonary bypass laboratory procedures.

Eliminating from physiologic circulation a significant amount of unnecessary perfluorocarbons (PFC) is advantageous since little is known about long-term effects of PFC in the circulatory system. The basic circuitry, cell-washer, mechanical manipulations, and overall concept revealed that a significant amount of PFC can be retrieved and estimated in volume and compared to initial volumes. A method of separating a certain PFC blood substitute from blood following laboratory cardiopulmonary bypass is described.

Penetrating intrapericardial wounds: clinical experience with a surgical protocol.

Background: From 1972 to 1977, a treatment protocol was developed at our institution for patients with suspected penetrating intrapericardial wounds. It consists of immediate transport to the operating room, pericardial decompression by subxiphoid pericardial window under local or light general anesthesia in patients in stable condition, and median sternotomy and operative repair with limited use of cardiopulmonary bypass.

Methods: The records of 79 consecutive patients with acute penetrating intrapericardial injury who underwent operation from March 1978 to July 1991 were reviewed.