Loss of alveolar bone density in postmenopausal, osteopenic women is associated with circulating levels of gelatinases.

Objective: To determine whether circulating levels of two matrix metalloproteinases, MMP-2 and MMP-9, are associated with loss of alveolar bone density (ABD) or height (ABH), or with progression of periodontitis (relative clinical attachment level [RCAL]), among postmenopausal women with local and systemic bone loss.

Background: This study was planned as part of a 2-year randomized, double-blind, placebo-controlled, clinical trial examining efficacy/safety of subantimicrobial dose doxycycline (20 mg bid) in postmenopausal osteopenic women. This study examines whether serum levels of gelatinases are associated with local changes in the periodontium.

Hedgehog and TGFβ signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma.

Oral Squamous Cell Carcinoma (OSCC) is the sixth most common cancer worldwide. OSCC invasion into the lymph nodes and mandible correlates with increased rates of recurrence and lower overall survival. Tumors that infiltrate mandibular bone proliferate rapidly and induce bone destruction.

The partially edentulous patient: fixed prosthodontics or implant treatment options.

The replacement of missing teeth by conventional fixed partial dentures or by implant supported prostheses occupies a major portion of the average restorative and prosthodontic practice. New materials, techniques, and technologies are constantly being added to our armamentarium. The demand for fixed prosthodontic patient services will continue to grow.

The single-unit crown: factors for clinical success.

Application of the crown preparation guidelines obtained through theoretical models, laboratory testing and clinical studies provide an evidence-based rationale for clinical practice procedures. The evidence-based rationale has been presented to support basic day-to-day techniques in clinical practice. As new techniques and materials are developed, each should be evaluated carefully prior to clinical use and acceptance.