471 results match your criteria: "University of Tennessee Memphis[Affiliation]"
Primary 3-Month Outcomes of a Double-Blind Randomized Prospective Study (The QUEST Study) Assessing Effectiveness and Safety of Novel High-Frequency Electric Nerve Block System for Treatment of Post-Amputation Pain.
J Pain Res
June 2024
Department of Pain Management, Cleveland Clinic, Cleveland, OH, USA.
Purpose: This multicenter, randomized, double-blinded, active sham-controlled pivotal study was designed to assess the efficacy and safety of high-frequency nerve block treatment for chronic post-amputation and phantom limb pain.
Patients And Methods: QUEST enrolled 180 unilateral lower-limb amputees with severe post-amputation pain, 170 of whom were implanted with the Altius device, were randomized 1:1 to active-sham or treatment groups and reached the primary endpoint. Responders were those subjects who received ≥50% pain relief 30 min after treatment in ≥50% of their self-initiated treatment sessions within the 3-month randomized period.
Mobility Rates After Lower-Limb Amputation for Patients Treated with Physician-Led Collaborative Care Model.
Ann Vasc Surg
August 2024
Division of Vascular Surgery, University of Tennessee-Memphis, Memphis, TN. Electronic address:
Background: Clinical outcomes after major lower-limb amputation have been historically poor. The current care provided to most amputees is often disorganized and without physician supervision. The primary purpose of this study is to examine rates of postamputation mobility achieved with a prosthesis by patients with chronic limb-threatening ischemia and/or diabetes who required major lower-limb amputation and were treated under an established physician-led collaborative care pathway.
View Article and Find Full Text PDFArticle Synopsis
- Many bee species possess specific cytochrome P450 enzymes (P450s) that help detoxify certain insecticides, but the alfalfa leafcutter bee lacks these enzymes and is significantly more sensitive to insecticides.
- Research investigated the P450 genes in various Megachilidae bee species, revealing that many lack the CYP9Q-related genes and instead have evolved distinct P450s that cannot metabolize common neonicotinoid insecticides.
- Conversely, some tribes within the Megachilidae, like Osmiini and Dioxyini, do have protective P450s that can detoxify these harmful chemicals, highlighting the need for better pesticide risk assessments based on these evolutionary patterns.
Objective: We measured utilization of clinician-performed head and neck ultrasound among otolaryngologists, endocrinologists, and general surgeons, using Medicare Provider Utilization and Payment Data.
Study Design: Retrospective analysis of Medicare billing database.
Setting: University.
A prospective evaluation of neck and shoulder function following treatments of early-stage human papillomavirus-associated oropharynx cancer.
Clin Otolaryngol
September 2023
Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, California, USA.
Objectives: To compare post-treatment neck and shoulder function between human papillomavirus-associated oropharynx squamous cell carcinoma (HPV + OPSCC) treatments.
Design: Prospective, repeated-measures study.
Setting: Tertiary care center.
Prospective quality of life outcomes for human papillomavirus associated oropharynx cancer patients after surgery alone.
Am J Otolaryngol
June 2023
Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California-San Francisco, San Francisco, CA, United States of America. Electronic address:
Purpose: To evaluate changes in patient-reported quality of life (QOL) to inform treatment decisions for human papillomavirus-associated oropharynx squamous cell carcinoma (HPV + OPSCC).
Materials And Methods: Patients with American Joint Committee on Cancer (AJCC) 8th edition cT0-T3 and cN0-N3 HPV + OPSCC treated with transoral robotic surgery to the primary site with neck dissection completed questionnaires prior to surgery and at three-months and one-year post-operatively. Questionnaires included four validated instruments: the University of Washington Quality of Life Questionnaire (UW-QOL), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and Head and Neck Module (HN35), and the Neck Dissection Impairment Index (NDII).
Article Synopsis
- The American Heart Association's Children's Research Network began in July 2017 with four programs focused on improving children's heart health through various research approaches at different hospitals across the U.S.
- Each center has specific goals: Children's National aims to address rheumatic heart disease, Duke focuses on obesity risk factors and treatments, Utah leverages big data for congenital heart defects, and Northwestern studies early cardiovascular health patterns.
- Despite challenges, including those posed by the COVID-19 pandemic, all centers surpassed their initial research productivity, training, and collaboration goals.
Fractional Flow Reserve or Intravascular Ultrasound for PCI.
N Engl J Med
December 2022
University of Tennessee Memphis, Memphis, TN
A Case of Severe Multisystem Inflammatory Syndrome in Children (MIS-C) Treated with Multiple Biologics.
Case Rep Rheumatol
August 2022
University of Tennessee Memphis, Department of Rheumatology, Memphis, USA.
Article Synopsis
- The COVID-19 virus has led to significant health impacts worldwide, especially highlighting severe outcomes like pneumonia and ARDS, along with a concerning autoinflammatory response in some patients.
- The delayed response to the virus can result in MIS-C, which is a potentially fatal inflammatory syndrome that necessitates early diagnosis and treatment to avoid permanent organ damage.
- A case study of a 12-year-old boy with severe MIS-C illustrates the critical interventions needed, such as immunomodulating therapies, to improve patient outcomes after requiring intensive medical support.
Management of the parotid for high-risk cutaneous squamous cell carcinoma: A review from the salivary section of the American Head and Neck Society.
Am J Otolaryngol
March 2022
Department of Otolaryngology - Head and Neck Surgery, University of Tennessee - Memphis, Memphis, TN, USA.
Background: Metastases to the parotid nodal basin in patients with high-risk cutaneous squamous cell carcinoma (HRcSCC) impact disease specific survival (DSS) and overall survival (OS).
Methods: A writing group convened by the Salivary Section of the American Head and Neck Society (AHNS) developed contemporary, evidence-based recommendations regarding management of the parotid nodal basin in HRcSCC based on available literature, expert consultation, and collective experience. The statements and recommendations were then submitted and approved by the AHNS Salivary Committee.
Lower Eyelid Ectropion Secondary to Over-the-Counter Treatment of Xanthelasma.
Ophthalmic Plast Reconstr Surg
January 2022
Tennessee Oculoplastics, Nashville, Tennessee, U.S.A.
Xanthelasmas are localized accumulations of lipids, mainly cholesterol, that can occur in the epidermis, dermis, and muscle of the eyelids. They are the most common cutaneous presentation of xanthoma and occur most commonly on the upper eyelid near the inner canthus. Despite their benign presence, xanthelasmas can be cosmetically concerning.
View Article and Find Full Text PDFEvaluation of Staged TCAR and Cardiac Surgery or Structural Heart Intervention.
Vasc Endovascular Surg
October 2021
Division of Vascular Surgery, University of Tennessee-Memphis, Memphis, TN, USA.
Article Synopsis
- The study examines TCAR (transcarotid artery revascularization stenting) as a treatment for patients with both carotid and cardiac disease, finding its effectiveness comparable to carotid endarterectomy (CEA).
- A review of 37 patients showed no major complications like heart or neurological issues after TCAR, although 8% did have a minor complication (neck hematoma).
- The results suggest that using TCAR before cardiac procedures is a safe and effective approach for patients with these dual conditions.
Uncaptured rates of postpartum venous thromboembolism: a US national analysis.
BJOG
September 2021
University of Miami Miller School of Medicine, Miami, FL, USA.
Objective: To quantify the proportion of postpartum venous thromboembolism (VTE) readmissions, including those that occur at different hospitals from index admission, and describe risk factors for this outcome.
Design: Retrospective observational study.
Setting: US hospitals included in the Nationwide Readmissions Database.
Elevated neutrophil-lymphocyte ratios in extremely preterm neonates with histologic chorioamnionitis.
J Perinatol
June 2021
Department of Pediatrics, Saint Louis University School of Medicine, St Louis, MO, USA.
Objective: Histologic chorioamnionitis (HCA) is a placental inflammation linked to preterm birth and adverse neonatal outcome. The neutrophil-lymphocyte ratio (NLR) can identify various inflammatory disorders, however its utility in HCA is not clear. Our goal was to examine NLR values and HCA diagnoses in at-risk pregnancies and neonates.
View Article and Find Full Text PDFIncreased Risk of ACLF and Inpatient Mortality in Hospitalized Patients with Cirrhosis and Hepatic Hydrothorax.
Dig Dis Sci
October 2021
Department of Medicine, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA.
Background: Hepatic hydrothorax (HH) remains a difficult-to-treat complication of cirrhosis.
Aim: To define the mortality, length of stay (LOS), and risk of ACLF in patients admitted with HH.
Methods: We utilized the North American Consortium for the Study of End-stage Liver Disease, a prospective cohort of 2868 non-electively hospitalized patients with cirrhosis from 14 tertiary care hepatology centers in North America.
Primary Melanoma of the Lacrimal Sac Treated With Pembrolizumab.
Ophthalmic Plast Reconstr Surg
May 2021
Tennessee Oculoplastics, Nashville, Tennessee, U.S.A.
Article Synopsis
- Primary melanoma of the lacrimal sac is rare but aggressive, often leading to high mortality and frequent recurrence.
- A patient was diagnosed with metastatic melanoma after a biopsy during routine surgery and treated with local excision and immunotherapy (pembrolizumab).
- Two years post-diagnosis, the patient shows significant improvement, emphasizing the importance of cancer genomics and a multidisciplinary approach in managing such cases.
Background In adults with heart failure, elevated heart rate is associated with lower survival. We determined whether an elevated heart rate was associated with an increased risk of death or heart transplant in children with dilated cardiomyopathy. Methods and Results The study is an analysis of the Pediatric Cardiomyopathy Registry and includes baseline data, annual follow-up, and censoring events (transplant or death) in 557 children (51% male, median age 1.
View Article and Find Full Text PDFMaternal trauma and fear history predict methylation and gene expression in newborns.
PeerJ
May 2020
Department of Gynecology and Obstetrics, Emory University, Atlanta, GA, United States of America.
Trauma and related fear exert significant influence on mental and physical health throughout the lifespan and are associated with intergenerational patterns of development, health, and behavior. DNA methylation and gene expression are involved in our developmental adaptations to our experiences and can be influenced by social interventions. Patterns of DNA methylation and expression of a gene involved in neurodevelopment and psychiatric risk () have been linked with childhood trauma.
View Article and Find Full Text PDFObjective: Internet delivery of behavioural weight control interventions offers potential for broad geographic reach and accessibility, but weight losses online fall short of those produced with the same programme delivered in-person. This pilot study examined feasibility and preliminary efficacy of a video-based platform for delivering weekly chat as part of a 6-month, 24-session online group behavioural weight control programme compared with the established text-based format, which has produced the best online weight losses to date.
Method: Women with obesity (N = 32) were randomized to either (a) weekly video group chat sessions and provided with a cellular-enabled scale (Video) or (b) Text-based weekly chat sessions and given a digital scale (Text) and followed for 6 months to determine weight loss and treatment engagement.
Expression of α-amylase in without antibiotics-resistant gene and effects of glycosylation on the enzymic thermostability.
3 Biotech
November 2019
1State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, School of Life Sciences, Hubei University, Wuhan, 430062 Hubei China.
Article Synopsis
- Thermostable α-amylases, particularly the one derived from BLA, show high thermal and pH stability, making them valuable for industrial use.
- The recombinant α-amylase Pic-BLA, produced without antibiotic resistance genes in yeast, achieved an impressive amylase activity of 900 U/mL and exhibited a significant increase in molecular mass due to deep glycosylation.
- Comparisons of thermostability between glycosylated Pic-BLA and non-glycosylated Eco-BLA indicate that glycosylation has minimal impact on the enzyme's heat tolerance.
Nonvisualization of Sentinel Lymph Nodes by Lymphoscintigraphy in Primary Cutaneous Melanoma: Incidence, Risk Factors, and a Review of Management Options.
Plast Reconstr Surg
October 2019
Department of Plastic and Reconstructive Surgery, University of Tennessee-Memphis, Memphis, Tenn.
A Survey of the Complex General Surgical Oncology Fellowship Programs Regarding Applicant Selection and Rank.
Ann Surg Oncol
September 2019
Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Article Synopsis
- There is a high demand for Complex General Surgical Oncology (CGSO) fellowships, yet clarity on academic and qualitative factors influencing applicant selection is lacking.
- A survey sent to CGSO fellowship program directors revealed that most have specific benchmarks for applicant qualifications, such as ABSITE scores and publication counts.
- The interview process is the most crucial factor in ranking candidates, with personal attributes like teamwork, communication skills, and surgical abilities being prioritized over personal statements.
Drug-Induced Sleep Endoscopy and Surgical Outcomes: A Multicenter Cohort Study.
Laryngoscope
March 2019
USC Caruso Department of Otolaryngology-Head & Neck Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California, U.S.A.
Objective: To evaluate the association between findings of blinded reviews of preoperative drug-induced sleep endoscopy (DISE) examinations using the VOTE Classification and obstructive sleep apnea (OSA) surgical outcomes in a large multicenter, international cohort.
Methods: Retrospective, multi-center cohort study of adults without tonsillar hypertrophy who underwent pharyngeal surgery for OSA. The study included only participants without enlarged tonsils.