5 results match your criteria: "University of Technology of Dresden[Affiliation]"
NRP2 transcriptionally regulates its downstream effector WDFY1.
Sci Rep
March 2016
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, U.S.A.
Neuropilins (NRPs) are cell surface glycoproteins that often act as co-receptors for plexins and VEGF family receptors. Neuropilin-2 (NRP2), a family member of NRPs, was shown to regulate autophagy and endocytic trafficking in cancer cells, a function distinctly different from its role as a co-receptor. WD Repeat and FYVE domain containing 1 (WDFY1)-protein acts downstream of NRP2 for this function.
View Article and Find Full Text PDFEffect of recombinant human keratinocyte growth factor (rHuKGF, Palifermin) on radiation-induced mouse urinary bladder dysfunction.
Int J Radiat Oncol Biol Phys
October 2007
Department of Radiotherapy and Radiation Oncology, University of Technology of Dresden, Dresden, Germany.
Purpose: To determine the effect of Palifermin (rHuKGF) on acute and late radiation effects in mouse urinary bladder.
Methods And Materials: Graded radiation doses were applied on day 0. Single subcutaneous injections of Palifermin (15 mg/kg) were given on day -2 or day +2.
Radiation induced late damage to the barrier function of small blood vessels in mouse bladder.
J Urol
December 2006
Department of Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology of Dresden, Fetscherstrasse 74, D-01307 Dresden, Germany.
Purpose: We identified changes in vascular barrier function in relation to collagen deposition during the late radiation response of mouse bladders. In this study albumin leakage was assessed as a marker of blood vessel barrier disruption.
Materials And Methods: Female C3H/Neu mice were irradiated with a single dose of 20 Gy and sacrificed for (immuno) histological studies after 90, 120, 180, 240 and 360 days.
Radiation-induced damage to mouse urothelial barrier.
Radiother Oncol
August 2006
Department of Radiotherapy and Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology of Dresden, Germany.
Purpose: To determine changes of the urothelial barrier during the early as well as late radiation response in mouse urinary bladder.
Materials And Methods: Groups of mice were irradiated with a single dose of 20Gy and sacrificed between days 0 and 360. Urothelial cell numbers were counted, and the fraction of urothelium with a positive immunohistochemical signal for uroplakin-III (UP-III) on the luminal surface of the bladder was defined.
Radiation induced inflammatory changes in the mouse bladder: the role of cyclooxygenase-2.
J Urol
April 2006
Clinic of Radiotherapy and Radiation Oncology, University of Technology of Dresden, Dresden, Germany.
Purpose: We assessed the effect of irradiation on COX-2 expression in blood vessels of the mouse bladder wall during the early and late radiation response phases. Vasodilatation was quantified as an additional marker of inflammation related to COX-2 activity.
Materials And Methods: Female C3H/Neu mice were irradiated with a single dose of 20 Gy.