15 results match your criteria: "University of Tabuk: 71491 Tabuk[Affiliation]"

Dysregulated Vitamin D, , , and Δ32 Gene Variations are Associated with Coronary Artery Disease.

Discov Med

November 2024

Department of Medical Lab Technology, Prince Fahad Bin Sultan Chair for Biomedical Research, Faculty of Applied Medical Sciences, University of Tabuk, 71491 Tabuk, Saudi Arabia.

Article Synopsis
  • - Insufficient vitamin D levels are linked to chronic conditions like cancers, diabetes, and cardiovascular diseases, particularly coronary artery disease (CAD), with enzymes involved in vitamin D metabolism potentially affecting these levels.
  • - The study analyzed genetic mutations (rs1562902 C > T, rs12255372 G > T, and Δ32 bp deletion) for their relationships with reduced vitamin D and CAD risk, using specific PCR techniques for genotyping.
  • - Results showed significant associations between certain genetic variants and higher CAD risk, particularly the rs1562902 C > T genotype and Δ32 deletion, suggesting these mutations may be genetic indicators for CAD susceptibility.
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Article Synopsis
  • The study examined how high-pressure processing (HPP) affects the composition and structure of micellar casein concentrates (MCC) derived from cow (BMCC) and goat (CMCC) milk under varying pressures of 100 to 500 MPa for 30 minutes.
  • It found significant increases in calcium and phosphorus solubility in BMCC, with solubility reaching over 90%, while CMCC showed lower increases; particle size also decreased more in BMCC than in CMCC.
  • Changes in protein structure were noted, with BMCC showing a decrease in fluorescence intensity (indicating higher surface hydrophobicity) and alterations in α-helix and β-sheet content, suggesting that HPP can effectively improve
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Mosquitoes are considered one of the most lethal creatures on the planet and are responsible for millions of fatalities annually through the transmission of several diseases to humans. Green trash is commonly employed in agricultural fertilizer manufacturing and microbial bioprocesses for energy production. However, there is limited information available on the conversion of green waste into biocides.

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Whole-Exome Sequencing Detecting a Recurrent Pathogenic Mutation, p.His63Asp (H63D) in COVID-19 Patients and Its Effect on Mortality.

Discov Med

July 2024

Department of Medical Lab Technology, Prince Fahad Bin Sultan Chair for Biomedical Research, Faculty of Applied Medical Sciences, University of Tabuk, 71491 Tabuk, Saudi Arabia.

Background: In recent years, various coronaviruses have caused severe respiratory illnesses worldwide. For example the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections of COVID-19 outbreak in 2019 in Wuhan, China. Genome-wide association studies (GWAS) have significantly expanded our comprehension of how specific genetic variations are linked to diseases.

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Application of edible nanocomposites from chitosan/fenugreek seed mucilage/selenium nanoparticles for protecting lemon from green mold.

Int J Biol Macromol

July 2024

Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, El-Sadat City 32897, Egypt.

Green (Penicillium digitatum) mold can severely endanger the citrus fruits production and quality. Targeting the protection of lemon fruits from green mold infestations with nanobiotechnology approach, the fenugreek seed mucilage (FM) was extracted and exploited for biosynthesis of selenium (SeNPs) nanoparticles; their nanocomposites (NCs) with chitosan (CT) was constructed and employed as antifungal materials and edible coating (ECs) to protect lemon fruits against green mold. The nanoparticles formation and conjugations were verified by infrared (FTIR) analysis and electron microscopy.

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In this study, we tackle the challenge of optimizing the design of a Brushless Direct Current (BLDC) motor. Utilizing an established analytical model, we introduced the Multi-Objective Generalized Normal Distribution Optimization (MOGNDO) method, a biomimetic approach based on Pareto optimality, dominance, and external archiving. We initially tested MOGNDO on standard multi-objective benchmark functions, where it showed strong performance.

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The new cationic surfactant-based azo Schiff compound (azoS8) was prepared, characterized, and investigated as a corrosion inhibitor for carbon steel in 1 M HCl by means of electrochemical approaches in this study. The chemical structure of azoS8 has been verified by the FTIR and H NMR spectra. According to the electrochemical system, the examined surfactant is a mixed-type inhibitor.

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Background: Diabetes mellitus (DM) is a metabolic disorder characterized by high blood glucose levels that occurs either due to insufficient insulin production or mounting resistance to its action. The purpose of this study was to investigate if methanolic extracts of seeds, , and leaves had any effect on blood sugar levels in normal and streptozotocin (STZ) diabetic rats, as well as to explore the most effective extract.

Method: Healthy male albino rats weighing 185-266 g were divided into nine groups of eight rats each: normal control, diabetic control, diabetic rats with dietary supplements of , , and methanolic extracts, and diabetics treated with insulin.

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The pathogenicity of HCC could be enhanced by TNF-α and NFκB, which are crucial parts of the inflammatory pathway inside the HCC microenvironment. Therefore, we aimed to discover the therapeutic effects of QNZ, an inhibitor of both TNF-α and NFκB, in an experimental model of HCC in rats. HCC was experimentally induced in rats by thioacetamide, and some of the rats were treated with QNZ.

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Therapeutic effects of blocking β-catenin against hepatocellular carcinoma-induced activation of inflammation, fibrosis and tumor invasion.

Biomed Pharmacother

March 2021

Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, 71491, Tabuk, Saudi Arabia. Electronic address:

Destructive effects of hepatocellular carcinoma (HCC) is enhanced by many cellular mechanisms including activation of fibrosis, inflammation and tumor invasion. Therefore, this study was conducted to investigate the therapeutic effects of iCRT14, β-catenin blocker, on HCC. In addition, the molecular effects of iCRT14 will be investigated on inflammation, fibrosis and tumor invasion pathways.

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Donepezil (DNPZ) has shown neuroprotective effect in many disorders. The current study tested the putative retinoprotection provided by donepezil in mouse diabetic retinopathy. Swiss albino mice were allocated to, 1] saline control, 2] diabetic, 3&4] diabetic+DNPZ (1 or 4 mg/kg).

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The present study is focused on the assembly of two new thin films based on the direct layer deposition of lanthanum ion from solution with two aryl-azo-pyrogallol ligands onto the surface of a glass substrate. Assembled lanthanum (III) complexes were characterized by different techniques including thermal gravimetric analysis, metal analysis by acid digestion and complexometric titration, Fourier transforms infrared, transmission electron microscopy, and X-ray diffraction. Two complexes were highly similar in their patterns and crystallinities with the characterized particle size range 23.

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The wild has a restricted distribution in small scattered areas of Jabal Al-Lauz (2580 m above sea level), a mountain in northwestern Saudi Arabia. Major objective of current study is to provide information about by analyzing its ecology in terms of floristic diversity, plant associations, environmental features, and its size structure and nutritional value. For this purpose, 12 stands of 20 m were selected along the Jabal Al-Lauz mountain ridge.

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[Purpose] This review synthesizes findings from studies on two forms of Constraint-Induced Movement Therapies: the original Constraint-Induced Movement Therapy and the modified Constraint-Induced Movement Therapy, in adult stroke patients including the evidence, current limitations and future directions. [Methods] We critically reviewed studies evaluating the effectiveness of Constraint-Induced Movement Therapies in chronic stoke focusing on the functional (i.e.

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Tannery wastewater pre-treatment.

Water Sci Technol

October 2009

Faculty of Engineering, University of Tabuk, PO. Box 741, 71491 Tabuk, Saudi Arabia.

Tannery wastewater is one of the most pollution sources. It can cause environmental problems related to its high organic matter, suspended solids and chromium. Chromium (III) salts are the most widely used chemicals for tanning processes, causing the tannery wastewater to be highly pollutant with chromium.

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