2,990 results match your criteria: "University of TUNIS El Manar[Affiliation]"

Advanced artificial intelligence framework for T classification of TNM lung cancer inFDG-PET/CT imaging.

Biomed Phys Eng Express

October 2024

University of Tunis El Manar, Faculty of Medicine of Tunis, Laboratory of Biophysics and Medical Technologies (Higher Institute of Medical Technologies of Tunis), Department of Nuclear Medicine, Salah Azaiez Institute, Tunis, Tunisia.

Article Synopsis
  • - The integration of AI in lung cancer management aims to enhance diagnostic and treatment strategies by automatically segmenting lung tumors and classifying lung cancer using PET/CT imaging.
  • - A modified ResNet-50 model was utilized for accurate tumor segmentation, producing 3D models that help visualize tumor boundaries for better treatment planning.
  • - The study's AI framework showed strong performance in classifying T stages of lung tumors, which is crucial for determining treatment options and assessing prognosis, ultimately improving patient outcomes.
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Vancomycin-resistant enterococci (VRE) are a public health concern as they lead to therapeutic impasses and play a pivotal role in the dissemination of vancomycin resistance genes. As recent evidence suggests that wildlife can play a role in the dissemination of bacterial resistomes, this study explored the potential role of Algerian wild birds as a reservoir of VRE. A total of 222 cloacal and fecal samples were collected from various wild bird species and screened for VRE using a selective medium.

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Background: Deficiency in vitamin D is widely prevalent around the world. Oral vitamin D supplementation is suggested for older adults to sustain appropriate 25-hydroxyvitamin D (25(OH)D) levels throughout the year. At present, cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) are the most commonly used compounds.

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The cyst of the canal of nuck: a great mimicker of groin hernia in female.

ANZ J Surg

December 2024

Department of General Surgery, Trauma and Great Burns Center of Ben Arous, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

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Soil contamination by trace elements and radioelements and related environmental risks in agricultural soils of the M'Dhilla Basin (southwestern Tunisia).

Environ Monit Assess

October 2024

Department of Geology, Sedimentary Environments, Oil Systems and Reservoir Characterization Laboratory, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Agricultural soil contaminated by phosphogypsum pile stocked in plan air remains a major problem in M'Dhilla city southwestern of Tunisia. The present effort aimed to enhance the knowledge of trace elements and radioactivity abundance and to assess the corresponding environment. X-ray fluorescence spectroscopy was used to evaluate the trace elements, radioactive elements, and major element concentrations.

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Unusual case report of bifocal gastrointestinal stromal tumor in the first jejunal loop uncovered by severe hemorrhage.

Int J Surg Case Rep

November 2024

General Surgery Department, Mahmoud El Matri Hospital, V59M+628, Ariana, Tunisia; Faculty of Medicine of Tunis, University of Tunis El Manar, R534+F9H, Rue de la Faculté de Médecine, Tunis, Tunisia.

Article Synopsis
  • Gastrointestinal stromal tumors (GISTs) are rare tumors in the digestive tract, making up only 1% of gastrointestinal tumors, with jejunal GISTs being even less common.
  • A unique case involved a 60-year-old woman who experienced severe gastrointestinal bleeding due to two jejunal GISTs, which were diagnosed after normal initial endoscopy but confirmed through imaging and jejunoscopy.
  • The case underscores the importance of recognizing rare presentations of GISTs, as well as the need for surgery and advanced diagnostic tools for effective treatment and management.
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Giant cell tumor of the cervical spine: A very uncommon cause for cervical spine compression.

Radiol Case Rep

December 2024

Department of Neurosurgery, Trauma and Burns Center, Ben Arous. University of Tunis - El Manar, Faculty of Medicine of Tunis, Ben Arous, Tunisia.

Giant cell tumors (GCTs) are rare neoplasms, primarily found in long bones, typically affecting the epiphysis of the distal femur, proximal tibia, and distal radius. However, their occurrence in the cervical spine is exceedingly rare. Here, we present a case report of a 21-year-old female patient who presented with progressive neck pain, radiating numbness, and right hemiparesis.

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Novel Inflammatory Markers Associated With Cutaneous Leukocytoclastic Vasculitis Etiology.

Indian Dermatol Online J

August 2024

Department of Internal Medicine, University of Tunis El Manar, Faculty of Medicine of Tunis, Department of Internal Medicine, 1007, Tunis, Tunisia.

Article Synopsis
  • The study aimed to compare inflammatory markers to help differentiate between secondary leukocytoclastic vasculitis (SLV) and idiopathic leukocytoclastic vasculitis (ILV).
  • Researchers analyzed clinical and laboratory data from 77 patients diagnosed with cutaneous leukocytoclastic vasculitis, calculating various ratios including PLR, NLR, CAR, and FAR.
  • Significant differences in these ratios were found between SLV and ILV groups, indicating that elevated ratios may suggest SLV, which warrants thorough evaluation in affected patients.
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Unusual coexistence of low-grade mucinous cystic neoplasm and idiopathic granulomatous hepatitis.

Int J Surg Case Rep

November 2024

University of Tunis El Manar, Faculty of Medicine of Tunis, Tunisia; Department of Surgery, Mongi Slim Hospital La Marsa, Tunisia.

Introduction And Importance: Mucinous cystic neoplasms (MCNs) of the liver are rare precancerous lesions, accounting for less than 5 % of all hepatic cysts. The coexistence of MCNs with idiopathic granulomatous hepatitis is exceedingly uncommon and lacks documentation in the existing literature.

Case Presentation: A 43-year-old Tunisian woman with no significant medical history presented with persistent right hypochondrium pain.

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Conservative treatment in uterine perivascular epithelioid cell tumor of uncertain malignant potential: a case report.

J Med Case Rep

October 2024

Department of Surgical Oncology, Salah Azaiez Institute, Faculty of Medicine of Tunis, University of Tunis El Manar, Boulevard 9 Avril 1938, Tunis, Tunisia.

Introduction: Perivascular epithelioid cell tumors are uncommon mesenchymal tumors. The genital tract is the most common extrarenal location. Preoperative diagnosis is rarely achieved owing to non-specific symptoms and imaging features.

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An easy and efficient approach for the synthesis of highly regioselective functionalized dihydronaphthalen-1(2)-one family of α-tetralones from functionalized tetralone precursors which derived from Morita-Baylis-Hillman (MBH) adducts as starting substrates has been developed. The target dihydronaphthalen-1(2)-ones are obtained through the oxidation of tetrahydronaphthalenes (THN) using DDQ as the oxidizing agent, conducted in aqueous acetic acid at reflux conditions. The yields obtained ranged from 90 to 98%.

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Article Synopsis
  • - The study investigates how a personalized dietary plan affects kidney stone formation (urolithiasis) and related urinary parameters over 3 months in patients with different types of kidney stones.
  • - It involved 69 patients with various types of stones and measured changes in urinary components like calcium, oxalate, and uric acid before and after the dietary intervention.
  • - Results showed significant reductions in urinary oxalate levels and improvements in crystalluria for some stone types, highlighting the positive impact of diet in managing kidney stones.
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Neurofilaments light chains as a diagnostic and predictive biomarker for Tunisian Multiple Sclerosis patients.

Mult Scler Relat Disord

November 2024

Neurology Department, LR18SP03, Razi University Hospital, 1 rue des orangers, Manouba, Tunis 2010, Tunisia; Faculty of Medicine of Tunis, University of Tunis El Manar, 15, Rue Djebel Lakhdhar, La Rabta, Tunis 1007, Tunisia; Clinical Investigation Center (CIC) "Neurosciences and Mental Health", Razi University Hospital, 1 rue des orangers, Manouba, Tunis 2010, Tunisia. Electronic address:

Background: Multiple Sclerosis (MS) course was shown to be more severe among North Africans compared to Caucasians. Validation of prognostic biomarkers of disease activity and severity is a priority in our practice.

Objective: We aimed to investigate the association between baseline cerebrospinal fluid (CSF) and serum NfL (sNFL) levels and disease activity and disability accrual in a cohort of Tunisian patients with MS.

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Article Synopsis
  • Inguinal lymph node metastasis and the number of metastatic lymph nodes (NMLN) are key prognostic factors in vulvar squamous cell carcinoma (VSCC), but the lymph node ratio (LNR) also reflects lymphadenectomy effectiveness.
  • This study analyzed data from 192 VSCC patients to assess the impact of LNR and lymph node count on overall survival (OS) and recurrence-free survival (RFS).
  • Results indicated significant findings with a 5-year OS of 52.5% and 5-year RFS of 55.8%, highlighting LNR, FIGO stage, and negative margins as critical independent prognostic factors.
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Case Study: Contribution of Extended Sequencing and Phylogeographic Analysis in the Investigation of Measles Outbreaks in Tunisia in 2019.

Vaccines (Basel)

September 2024

Laboratory of Clinical Virology, WHO Reference Laboratory for Poliomyelitis and Measles in the Eastern Mediterranean Region, Pasteur Institute of Tunis, University Tunis El Manar (UTM), Tunis 1002, Tunisia.

Despite the availability of an effective vaccine for several decades, the measles virus continues to spread worldwide. From 2018 to 2019, several countries experienced large measles outbreaks with genotype B3, including Tunisia. We analyzed 66 samples collected from serologically confirmed measles cases during this outbreak.

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Article Synopsis
  • The study focuses on the diplectanid monogenean, a common gill parasite of the gilthead seabream found in the Mediterranean Sea, aiming to understand its population structure and genetic diversity through molecular analysis.
  • Researchers analyzed samples from wild and cage-reared gilthead seabream across fifteen locations in Tunisia, Italy, and Spain, revealing that there is likely just one species of the parasite widespread throughout the region, with evidence of recent population expansion.
  • The study shows high haplotype diversity and significant genetic variation among the parasite populations, with notable differences between those in the Adriatic Sea and other areas, suggesting considerable gene flow due to host movement.
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Reversion of neurovirulent mutations, recombination and high intra-host diversity in vaccine-derived poliovirus excreted by patients with primary immune deficiency.

J Med Virol

September 2024

Laboratory of Clinical Virology, WHO Regional Reference Laboratory for Poliomyelitis and Measles for the EMR, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.

Article Synopsis
  • * A study examined the genetic evolution of PV genomes from MHC class II-deficient PID patients, using stool samples to detect the virus through several advanced techniques, including full genome sequencing.
  • * Results indicated that while one patient cleared the virus with few mutations, two others showed significant genetic diversity in the virus, leading to severe outcomes and potential paralysis, highlighting the need for further research on the implications of intra-host diversity in PV evolution.
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Caligus minimus Otto, 1821 has been known for over two centuries and it is the second oldest of the approximately 275 species of Caligus O. F. Müller, 1985.

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Introduction: Stercoral perforation of the colon is a rare and life-threatening condition caused by pressure necrosis due to fecal impaction. It is commonly associated with chronic constipation, particularly in patients with neurogenic bowel disorders or prolonged opioid use. However, its occurrence in the context of chronic heroin use is rarely reported.

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We present quantum coupled-state calculations for the rotational excitation of interstellar propargylimine due to collisions with helium. The calculations are based on new high-accurate three-dimensional potential energy surfaces (3D-PESs) adapted for rigid-rotor scattering computations. The two PESs (/-PGIM-He) were determined using the explicitly correlated coupled-cluster approach with single, double and perturbative triple excitation [CCSCD(T)-F12] and the standard aug-cc-pVTZ basis set.

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Antiviral responses induced by double-stranded RNA (dsRNA) include RNA interference (RNAi) and pattern-triggered immunity (PTI), but their relative contributions to antiviral defence are not well understood. We aimed at testing the impact of exogenous applied dsRNA on both layers of defence against potato virus X expressing GFP (PVX-GFP) in Nicotiana benthamiana. Co-inoculation of PVX-GFP with either sequence-specific (RNAi) or nonspecific dsRNA (PTI) showed that nonspecific dsRNA reduced virus accumulation in both inoculated and systemic leaves.

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