2,990 results match your criteria: "University of TUNIS El Manar[Affiliation]"
NeuroVar: an open-source tool for the visualization of gene expression and variation data for biomarkers of neurological diseases.
GigaByte
November 2024
Department of Computer Science, Faculty of Science, University of Ibadan, 200132, Ibadan, Oyo State, Nigeria.
Article Synopsis
- A new tool called NeuroVar was developed to help visualize and analyze large genomic data, specifically focusing on neurological diseases.
- It uses an interactive Shiny application and a standalone desktop version for easy access and user experience.
- NeuroVar allows users to explore genetic variations and gene expression profiles by filtering data from the ClinGen database, and it's available for free on GitHub.
Interstitial 11q deletion in a patient with Sprengel's deformity: a case report and review of the literature.
Mol Cytogenet
December 2024
Department of Genetics, Charles Nicolle Hospital, Tunis, Tunisia.
Article Synopsis
- The article discusses a rare genetic abnormality involving deletions on chromosome 11, specifically between the 11q13 and 11q23 regions, which can lead to various clinical features including intellectual disabilities and malformations, though these do not consistently correlate with specific genetic patterns.* -
- The case study focuses on a 9-year-old boy exhibiting Sprengel's deformity, iris and chorioretinal coloboma, and mild motor development delay, identified to have a significant interstitial deletion on chromosome 11 through advanced genetic testing methods.* -
- The findings emphasize the variability in symptoms associated with 11q deletions and suggest that the observed deformities might not have a direct genetic link but rather could be
Atomic Force Microsocopy: Key Unconventional Approach for Bacterial Nanotubes Characterization In Vivo.
ACS Omega
November 2024
Laboratoire de Physique des Solides (LPS), UMR CNRS 8502, University Paris-Saclay, University Paris-Sud, Orsay 91405, France.
Article Synopsis
- Bacterial communication plays a critical role in controlling growth and addressing issues like antimicrobial resistance and energy production in Microbial Fuel Cells.
- Recent findings have identified a novel type of communication between bacteria using nanotubes, which are tiny filaments enabling direct nutrient exchange between neighboring cells.
- This study utilizes atomic force microscopy (AFM) in liquid to provide the first direct visualization of bacterial nanotubes on live bacteria, shedding light on their properties and potential applications in managing bacterial behavior.
Symptomatic diffuse cystic lymphangioma of the spleen in an adult: A case report.
Int J Surg Case Rep
January 2025
Department of General Surgery, Trauma and Burns Center, Ben Arous, University of Tunis El Manar, Tunisia.
Article Synopsis
- * A case study of a 54-year-old woman with chronic left upper quadrant pain led to the discovery of a 3.9 cm non-vascular splenic mass, confirmed as cystic lymphangioma through imaging and requiring laparoscopic splenectomy for symptomatic relief.
- * Though rare in adults, splenic cystic lymphangiomas can necessitate surgery if symptomatic, with imaging being crucial for diagnosis, and laparoscopic splenectomy being the preferred treatment due to its effectiveness and safety.
Relationship Between Cognitive Estimation, Executive Functions, and Theory of Mind in Patients With Prefrontal Cortex Damage.
Arch Clin Neuropsychol
November 2024
Univ Angers, Universite de Nantes, LPPL, SFR CONFLUENCES, 2 Boulevard Lavoisier, 49045 Angers Cedex 01, France.
Objective: Conflicting evidence has arisen from the few studies that have examined the role of the prefrontal cortex and executive control functions in theory of mind (ToM). Moreover, the involvement of other cognitive domains in the ability to infer mental states is still under debate. This study aims to examine, in addition to the potential contribution of executive functions, the role of cognitive estimation in ToM abilities, given that cognitive estimation processes are strongly associated with some aspects of executive control functions.
View Article and Find Full Text PDFThe 14-bp insertion/deletion as a promising gene polymorphism to understand cancer risk: Evidence from a systematic review and comprehensive meta-analysis.
Heliyon
November 2024
Laboratory of Microorganismes and Active Biomolecules, Sciences Faculty of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Article Synopsis
- HLA-G 14-bp insertion/deletion polymorphism is linked to cancer risk, particularly associated with the D allele, suggesting it may contribute to cancer cell escape mechanisms.
- A meta-analysis of 39 studies showed a significant association between this polymorphism and breast cancer, with specific variations in risk based on ethnicity and geographic location.
- Significant cancer risks linked to the D allele were observed in populations from North Africa, the Middle East, and South America, but no such risks were noted in Europe or North Asia.
Predictive Factors for Fertility of Daughter Cysts in Hepatic Cystic Echinococcosis and Insights into the Origin of Daughter Cysts.
Surg Infect (Larchmt)
November 2024
Faculty of Medicine, Department of General and Digestive Surgery, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.
Article Synopsis
- The study investigates the fertility of daughter cysts (DC) from hepatic echinococcal cysts to understand their origin, amidst ongoing debates about their developmental potential.
- A total of 248 DC from 27 cysts in 21 patients were analyzed, revealing a fertility rate of 64.5%, with specific factors such as cyst size, DC size, and WHO classification type CE2 significantly influencing fertility.
- The results indicate most DC were fertile, and the absence of hooks in infertile DC challenges existing theories about their formation.
Exploring Polysaccharides: Extraction, Characterization, and Analysis of Antioxidant and Antimicrobial Properties.
Polymers (Basel)
November 2024
Laboratory of Biotechnology and Biogeoresources Valorization, Higher Institute of Biotechnology of Sidi Thabet (ISBST), LR11ES31, Ariana 2020, Tunisia.
Article Synopsis
- - Polysaccharides were extracted from leaves (WSPRaL) and stems (WSPRaS) of a plant, yielding about 3% and 3.25%, respectively, with varying compositions of proteins, lipids, and sugars.
- - Detailed analyses showed that WSPRaL and WSPRaS contain different types of carbohydrates, with SEM and FT-IR used to examine their microstructure and physicochemical properties.
- - The polysaccharides demonstrated strong antioxidant, antibacterial, and biofilm-inhibitory activities, suggesting their potential as functional ingredients in the food and nutraceutical industries.
Uncovered: Integrating Experimental and Computational Approaches to Antibacterial and Phytochemical Profiling.
Pharmaceuticals (Basel)
November 2024
Department of Biology, College of Science, University of Ha'il, Ha'il 81451, Saudi Arabia.
Article Synopsis
- - The study investigates the biological properties of ginger rhizome grown in Sudan, focusing on its antibacterial, antioxidant, and phytochemical properties to assess its potential for medicinal use
- - Results show that the Sudanese ginger extract exhibits moderate antibacterial activity against various bacteria, with specific inhibition and bactericidal concentrations identified, alongside a diverse range of chemical constituents found through phytochemical screening
- - The research suggests a promising future for ginger rhizome in pharmaceutical development, with detailed molecular interactions supporting its antimicrobial potential, as revealed by GC-MS analysis and computational studies
In-Depth Analysis of L. Leaf Extract: Alleviating Pulmonary Histological Disturbances, Pro-Inflammatory Responses, and Oxidative Stress from Isolated or Combined Exposure to Inhaled Toluene and Noise in Rats.
Biology (Basel)
November 2024
Laboratory of Research "LR 23/ES/10": Population Pathology, Environmental Aggressors, Alternative Therapy, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis 1068, Tunisia.
Article Synopsis
- This study examined the lung damage in rats due to exposure to inhaled toluene and noise, focusing on the protective effects of L. leaf extract (OLE).
- Rats were divided into groups based on different exposure combinations and received OLE treatment over six weeks.
- Results showed that toluene and noise exposure caused significant lung tissue damage and inflammation, while OLE treatment reduced oxidative stress and inflammation, suggesting its potential as a therapeutic agent for lung health.
Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81.
Sci Rep
November 2024
Faculty of Medicine of Tunis - LR99ES09 Research Laboratory «Antimicrobial resistance», University of Tunis El Manar, 1007, Tunis, Tunisia.
Article Synopsis
- Fluoroquinolone-resistant (FQs-R) E. coli from patients undergoing prostate biopsies are increasingly common, raising concerns about using FQs for infection prevention.
- A study between 2016 and 2018 found that 61.06% of patients carried FQs-R Enterobacterales, primarily E. coli, with varying resistance profiles linked to specific genetic mutations.
- The research highlighted that these resistance mechanisms, including mutations in the gyrA and parC genes as well as certain plasmid-mediated resistance genes, significantly elevate the Minimum Inhibitory Concentrations (MICs), posing a risk for post-procedure infections.
Characterization of Yeast Isolated from the Gut Microbiota of Tunisian Children with Autism Spectrum Disorder.
J Fungi (Basel)
October 2024
Department of Immunology, Microbiology and Parasitology, Faculty of Medicine and Nursing, University of the Basque Country, UPV/EHU, 48080 Bilbao, Spain.
Article Synopsis
- Research on the microbiota-gut-brain axis in autism has largely focused on bacteria, with fungi being underexplored, prompting a study on fungal involvement in Tunisian children with autism spectrum disorder.
- The study involved fecal sample analysis from 28 autistic children and 46 controls; they identified fungal isolates and tested their antifungal susceptibility and virulence factors.
- Results showed a significant presence of fungi in both groups, with specific antifungal resistance and virulence traits in the isolates, indicating a potential link between gut fungi and autism that warrants further investigation.
High Prevalence of aCL-IgA and aβ2GPI-IgA in Drug-Free Schizophrenia Patients: Evidence of a Potential Autoimmune Link.
Antibodies (Basel)
November 2024
Faculty of Medicine of Sousse, University of Sousse, Sousse 4002, Tunisia.
Article Synopsis
- Schizophrenia (SZ) may have an autoimmune aspect, as indicated by higher levels of antiphospholipid antibodies in patients compared to healthy individuals.
- * The study analyzed serum samples from 80 drug-free SZ patients and 80 matched controls, finding significantly elevated aCL-IgM, aCL-IgA, and aβ2GPI-IgA levels in SZ patients.
- * These findings suggest a potential autoimmune link in SZ, warranting further research into the role of these antibodies in the disease's development and their connection to antiphospholipid syndrome.
French-Speaking Network of Pharmacogenetics (RNPGx) Recommendations for Clinical Use of Mavacamten.
Clin Pharmacol Ther
February 2025
Laboratoire de Pharmacologie et Toxicologie NeuroCardiovasculaire, UR7296, Hopitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France.
Mavacamten, the first drug in the class of β-cardiac myosin modulator, is used for the treatment of patients with hypertrophic cardiomyopathy. This orally administered drug demonstrates wide interpatient variability in pharmacokinetics parameters, due in part to variant CYP2C19 alleles. Individuals who are CYP2C19 poor metabolizers have increased exposure and are at increased risk of reduced cardiac hypercontractility.
View Article and Find Full Text PDFTardive seizure after electroconvulsive therapy: Prevalence and associated factors.
Encephale
November 2024
University of Tunis El Manar, Faculty of Medicine of Tunis, Department of Psychiatry D, Razi Hospital, Manouba, Tunisia.
Article Synopsis
- Tardive seizures are rare, spontaneous seizures that can occur after electroconvulsive therapy (ECT), potentially leading to severe complications like status epilepticus, and the risk factors and management are not well-defined.
- This study aimed to explore the prevalence of tardive seizures in patients undergoing ECT at Razi Hospital over seven years and to identify factors linked to this occurrence.
- The retrospective analysis included 1,931 ECT sessions from 157 patients, revealing a 4.45% incidence of tardive seizures among patients and a prevalence rate of 0.57% for individual sessions.
Plasma levels and diagnostic utility of VEGF, MMP-9 and TIMP-2 in the diagnosis of psoriasis forms.
Growth Factors
October 2024
Laboratory of Biochemistry, La Rabta Hospital Tunis and LR99ES11, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia.
Article Synopsis
- Psoriasis is a common autoimmune skin disease, but its exact cause is still unclear; this study explores whether specific biomarkers can indicate the presence and severity of the condition.
- The research focuses on the relationship between serum levels of VEGF, MMP-9, and TIMP-2 in 115 psoriatic patients compared to 51 controls, using ELISA methods for measurement.
- Findings show that while VEGF has low effectiveness in distinguishing between psoriasis variants, the combination of TIMP-2 and inflammation Z-score significantly improves discriminative power, highlighting the role of inflammation and tissue damage in the disease's progression.
Neglected knee swelling: A case report of massive synovial chondromatosis.
Int J Surg Case Rep
December 2024
University of Tunis El Manar, Faculty of Medicine of Tunis, 1007, Tunisia; Department of Orthopedic Surgery, Hospital Mongi Slim, La Marsa, Tunisia.
Article Synopsis
- * A case presented involved a 68-year-old man who underwent surgery to remove a large mass in his knee caused by SC, which was confirmed through histological examination.
- * Early diagnosis and timely surgical intervention are crucial in managing SC to prevent complications, while vigilance is needed for potential malignant transformation in resistant cases.
A large gastric inflammatory fibroid polyp revealed by an upper gastrointestinal bleeding: a case report.
Future Sci OA
December 2024
Department of Gastroenterology, Mohamed Taher Maamouri Hospital, Nabeul, Tunisia.
Article Synopsis
- - Inflammatory fibroid polyps (IFPs) are uncommon lesions found in the stomach, making up just 0.1% of gastric polyps, and often show no symptoms.
- - When symptoms do occur, they can include abdominal pain and gastrointestinal bleeding, particularly if the polyp becomes ulcerated.
- - A case study is presented involving a 72-year-old woman with a 35mm IFP in the prepyloric region, which was discovered after she experienced upper gastrointestinal bleeding and epigastric pain, leading to an endoscopic resection.
Deciphering the Resistome and Mobiolme of an Avian-Associated ST249 Clone that Acquired Vancomycin Resistance Isolated from Neutropenic Patient in Tunisia.
Microb Drug Resist
December 2024
Laboratory Ward, National Bone Marrow Transplant Center, Tunis, Tunisia.
Article Synopsis
- - The study identified the first vancomycin-resistant Enterococcus (VREfs) strain in Tunisia from an 8-year-old patient with bone marrow issues, using whole-genome sequencing (WGS) after isolating it during a hospital stay.
- - The strain showed significant resistance levels, with minimum inhibitory concentrations of vancomycin >256 mg/L and teicoplanin at 16 mg/L, and was classified as the ST249 clone typically found in avian sources.
- - This report highlights a novel case where an initially vancomycin-susceptible strain acquired resistance via a plasmid that carried a transposon, aided by specific genetic mechanisms related to conjugation and CRISPR interference
Pulmonary actinomycosis complicating COVID-19 pneumonia in an immunocompetent patient: a case report.
Future Sci OA
December 2024
Pulmonology Department, Mohamed Taher Maamouri University Hospital Nabeul University of Tunis El Manar, Nabeul, Tunisia.
Article Synopsis
- - A case study reports a 48-year-old male smoker who developed pyopneumothorax after experiencing pneumonia caused by COVID-19, requiring oxygen support and antibiotic treatment.
- - After initial recovery, he experienced hemoptysis, leading to a diagnosis of actinomycosis through endoscopic biopsy histopathology.
- - The patient responded well to prolonged antibiotic therapy with amoxicillin, highlighting the need to consider pulmonary actinomycosis in patients displaying lasting respiratory symptoms post-COVID-19.
Article Synopsis
- - The study investigates the nutritional status of breast cancer patients undergoing chemotherapy and explores how nutrition affects the severity of chemotherapy-related digestive issues.
- - Conducted on 107 women with an average age of 52, the study found that 41% were malnourished, 80% experienced constipation, and strong adherence to a Mediterranean diet was linked to less severe nausea and constipation.
- - The results emphasize the importance of early nutritional intervention to enhance the tolerance and effectiveness of chemotherapy treatments in breast cancer patients.
The fastest 24-hour ultramarathoners are from Eastern Europe.
Sci Rep
November 2024
Institute of Primary Care, University of Zurich, Zurich, Switzerland.
Article Synopsis
- Ultramarathon running, especially 24-hour races, is becoming increasingly popular, yet there's limited knowledge about the origins of top runners and their fastest race locations.
- A study utilizing a machine learning model analyzed over 171,000 race records and found that the majority of athletes come from the USA and Europe, with Tunisians showing the fastest average speeds.
- The study revealed a strong connection between an athlete's country of origin and the race location, with the fastest races occurring in Israel, Romania, and other European and Asian countries; men generally ran faster than women, particularly in age groups 35-49.
Inguinal swelling unveiling biphasic synovial sarcoma: A case report.
Int J Surg Case Rep
December 2024
University of Tunis El Manar, Faculty of Medicine of Tunis, 1007, Tunisia; Private Pathology Laboratory, Tunis, Tunisia.
Article Synopsis
- * A 35-year-old man was diagnosed with biphasic synovial sarcoma after imaging and biopsy confirmed a mass in his right inguinal area; he underwent successful surgery and received radiation therapy post-operation.
- * The case emphasizes the importance of using various diagnostic tools, like MRI and CT scans, for staging the tumor and that a tailored treatment approach is crucial for managing this rare condition.
Prevalence and Associated Factors of Falls in Persons with Multiple Sclerosis: A Cross-Sectional Study.
Tunis Med
November 2024
Physical Medicine and Rehabilitation Department, Military Hospital of Tunis, Tunisia.
Article Synopsis
- Multiple sclerosis (MS) is a disabling condition affecting the brain and spinal cord, and falls pose a significant health risk for individuals with MS (PwMS).
- A study conducted at the Military Hospital of Tunis surveyed 30 PwMS to assess the frequency and factors associated with falls, finding that 21 participants had fallen at least once.
- Results indicated that certain clinical assessments and factors, like MS walking ability and vestibular issues, were significantly linked to the likelihood of falls, underlining the importance of using specific scales to identify individuals at risk.
[Not Available].
Tunis Med
November 2024
Pneumology Department, Hospital of the Internal Security Forces La Marsa, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Introduction: Epistaxis in children is a very common reason for consultation in ENT and pediatric emergencies. Most of these epistaxis are benign, but it is their recurrence that motivates anxious parents, to consult. Allergic rhinitis is a common pathology among children in Tunisia, it seemed interesting to us to study the association between allergic rhinitis and epistaxis.
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