Test-Retest Reliability of Mismatch Negativity and Late Discriminative Negativity Response in Children With Listening Difficulties.

The aim of the study was to determine the test-retest reliability of MMN and LDN recorded to simple speech contrasts in children with listening difficulties. MMN and LDN responses were recorded from Fz and Cz electrodes for a /da/-/ga/ contrast twice within a 10-day period. To extract MMN and LDN, auditory-evoked responses to /ga/ stimuli presented alone were subtracted from the responses to /ga/ presented within an oddball sequence.

Global Algorithm for the Endovascular Treatment of Chronic Femoropopliteal Lesions: An Interdisciplinary Expert Opinion Statement.

A global treatment algorithm was developed for the endovascular revascularization of femoropopliteal lesions and chronic total occlusions, aiming toward a more standardized approach to endovascular treatment in patients with peripheral artery disease. The following steps are proposed. 1) Evaluation of lesion morphology based on preprocedural imaging by Duplex sonography and intravenous ultrasound for selection of lesion preparation tools.

Effectiveness of primary-contact physiotherapy in managing musculoskeletal conditions in emergency departments: protocol for the RESHAP-ED randomised controlled trial.

Introduction: Patients with musculoskeletal conditions often seek care in an emergency department (ED). The problem is that the time required to manage these patients places an additional pressure on ED physician and nursing staff, who are primarily trained and resourced to manage high-acuity patients. Primary-contact physiotherapists could play a greater role in supporting ED physician and nursing staff in the management of patients presenting to the ED with musculoskeletal conditions.

Trends in opioid dispensing to injured workers following codeine scheduling changes in Australia: a retrospective cohort study.

Objectives: To describe the prevalence and patterns of opioid analgesic and pain medicine dispenses, and the impact of up-scheduling of low-dose (≤15 mg) codeine-containing products to Australians with accepted workers' compensation time loss claims for musculoskeletal conditions between 2010 and 2019.

Design: Interrupted time series.

Setting: Workers' compensation scheme in Victoria, Australia.

Quercetin loaded biogenic squalene nano-lipid carriers for the treatment of dry eye syndrome.

In this study, quercetin-incorporated squalene nanostructured lipid carriers (QS-NLCs) were developed to mitigate the pathological conditions of dry eye disease (DED). The melt emulsification method was used to prepare QS-NLCs. The resulting NLCs have 93.

Immo-bile-izing CD8 T cell anti-tumor immunity.

Hepatocellular carcinoma is poorly responsive to immune checkpoint blockade. In a recent issue of Science, Varanasi et al. reveal how bile acids dampen anti-tumor CD8 T cell responses in the liver, contributing to cancer progression and poor immunotherapy outcomes.

Extreme storm events drive beach connectivity through headland bypassing.

Headland bypassing is a mainly wave-driven coastal process that interconnects sediment compartments and allows the continuity of longshore sediment transport. In turn, waves are subject to the variability of atmospheric patterns and climate drivers. This study focuses on identifying the atmospheric systems and associated hydrodynamic conditions that have triggered bypassing pulses in the study area, Fingal Head (New South Wales, Australia), over the last 33 years.

Excitatory and inhibitory neurotransmitter alterations with advancing age and injury in the mouse retina.

Increasing age and elevated intraocular pressure (IOP) are the two major risk factors for glaucoma, the most common cause of irreversible blindness worldwide. Accumulating evidence is pointing to metabolic failure predisposing to neuronal loss with advancing age and IOP injury. Many neurotransmitters are synthesized from endogenous metabolites and are essential for correct cell to cell signaling along the visual pathways.

A novel layered porous Fe, Cu dual-loading biochar heterogeneous catalyst to guided non-free radical pathway for peroxymonosulfate activation.

Engineering active sites on catalyst surface to enhance selective oxidation pathways in advanced oxidation processes (AOPs) is key to the efficient removal of pollutants. In this work, a method of loading bimetallic ions and simultaneously activating the surface of swine manure biochar using cetyltrimethylammonium bromide (CTAB) was developed. By applying SiO templating method to increase the surface area and pore size of the catalyst, this study prepared a copper-iron-loaded layered porous catalyst (CFBC-0.

Cultural diversity in early hearing detection and intervention: service provider perspectives.

This study investigated service providers' perspectives on the barriers experienced by families from culturally and linguistically diverse backgrounds along the Early Hearing Detection and Intervention (EHDI) pathway in Victoria, Australia. Twelve service providers (i.e.

A Longitudinal Study of Reading and Mental Health Development in Children With Reported Ear and Hearing Difficulties.

Purpose: Reported ear and hearing difficulties (rEHD) are known to be associated with reading difficulties as well as mental health problems. In this study, we aim to examine the relationship between reading and mental health in children with rEHD.

Method: In this study, we used structural equation modeling to measure the strength of longitudinal relationships between reading and mental health-related variables in children with rEHD-aged 5-11 years-in four large longitudinal databases from the United Kingdom ( = 5,254), the United States (s = 1,541 and 6,401), and Australia ( = 2,272).

Patient Perspectives on Conversational Artificial Intelligence for Atrial Fibrillation Self-Management: Qualitative Analysis.

Background: Conversational artificial intelligence (AI) allows for engaging interactions, however, its acceptability, barriers, and enablers to support patients with atrial fibrillation (AF) are unknown.

Objective: This work stems from the Coordinating Health care with AI-supported Technology for patients with AF (CHAT-AF) trial and aims to explore patient perspectives on receiving support from a conversational AI support program.

Methods: Patients with AF recruited for a randomized controlled trial who received the intervention were approached for semistructured interviews using purposive sampling.

Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients.

The human genome project ushered in a genomic medicine era that was largely unimaginable three decades ago. Discoveries of druggable cancer drivers enabled biomarker-driven gene- and immune-targeted therapy and transformed cancer treatment. Minimizing treatment not expected to benefit, and toxicity-including financial and time-are important goals of modern oncology.

Atrial fibrillation burden in clinical practice, research, and technology development: a clinical consensus statement of the European Society of Cardiology Council on Stroke and the European Heart Rhythm Association.

Atrial fibrillation (AF) is one of the most common cardiac diseases and a complicating comorbidity for multiple associated diseases. Many clinical decisions regarding AF are currently based on the binary recognition of AF being present or absent with the categorical appraisal of AF as continued or intermittent. Assessment of AF in clinical trials is largely limited to the time to (first) detection of an AF episode.

Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis.

Pancreatic cancer (PC) is a highly metastatic malignancy. More than 80% of patients with PC present with advanced-stage disease, preventing potentially curative surgery. The neuropeptide Y (NPY) system, best known for its role in controlling energy homeostasis, has also been shown to promote tumorigenesis in a range of cancer types, but its role in PC has yet to be explored.

Policy decisions matter: Cessation of logging benefits 34 threatened species in Victoria, Australia.

In January 2024, the Australian state of Victoria committed to ending native forest logging six years ahead of schedule, a decision that has been advocated for by scientists and conservationists for decades. However, the direct benefits for threatened species from this policy change has not been quantified. This study assesses the spatial overlap between areas approved for logging and the habitats of nationally listed threatened species, to estimate the potential impacts of continued logging and the likely benefits of its cessation.

Understanding the expectations, positions and ambitions of LMICs during pandemic treaty negotiations, and the factors contributing to them.

Global South countries account for two-thirds of WHO Member States and are a crucial voice in negotiating the 'pandemic treaty', which Member States agreed was necessary if the world was to avoid a repeat of the significant inequity that resulted during COVID-19. The negotiation of a pandemic treaty presents an opportunity to recalibrate global health systems and processes for pandemic prevention, preparedness and response. However, for this to eventuate through global solidarity, as many Global South countries have said they expect, then concessions by developed states on issues that they have long protected must occur.

We are not doing enough: Truth-telling and Aboriginal and Torres Strait Islander history in Australian Public Health.

Most public health practitioners and researchers in Australia acknowledge the poorer health and wellbeing of Aboriginal and Torres Strait Islanders peoples relative to non-Indigenous Australians; some work with Aboriginal and Torres Strait Islander communities; however, few acknowledge the role that public health itself has played in the plight of Aboriginal and Torres Strait Islanders peoples throughout Australia's colonial history. In this essay, we - Aboriginal, Torres Strait Islander, and non-Indigenous scholars at the Sydney School of Public Health (SSPH) - argue that truth-telling, which is critical for reconciliation, can only truly begin in Australian public health circles when we listen to the stories and truths of Aboriginal and Torres Strait Islander peoples as it relates to the colonial history of public health in Australia. Herein we give a brief outline of that history and provide some recommendations on ways forward; we also describe the successes and failures at SSPH in hopes that our story can help the broader Australian public health community on their truth-telling journeys.

Nurses, Chaplains, Clergy and Measurement Scales.

Much of the research in this issue relates to the long-standing profession of nursing and, secondly, the even longer established professions of chaplaincy and the clergy. This issue also provides evidence of the ever-increasing number of religious and spirituality measurement scales, as well as various other forms of religious and/or spiritual evaluations and the associated psychometric properties. Several articles researching religiosity/spirituality, however, identify common research limitations, in particular the error of using contaminated scales and the need to avoid tautological and uninterpretable results.

Could adaptive deep brain stimulation treat freezing of gait in Parkinson's disease?

Next-generation neurostimulators capable of running closed-loop adaptive deep brain stimulation (aDBS) are about to enter the clinical landscape for the treatment of Parkinson's disease. Already promising results using aDBS have been achieved for symptoms such as bradykinesia, rigidity and motor fluctuations. However, the heterogeneity of freezing of gait (FoG) with its wide range of clinical presentations and its exacerbation with cognitive and emotional load make it more difficult to predict and treat.

Fan therapy for breathlessness - how do you do it and why?

Purpose Of The Review: This review summarises high-level evidence for fan therapy and adds a commentary on the relatively-neglected question of how to optimise benefits based on qualitative evidence, clinical experience and broader research and theory.

Recent Findings: Recent high-level evidence suggests the fan reduces time to recovery from episodic breathlessness rather than reduces daily levels over a longer period. Lower grade evidence suggests the fan can also help people increase their physical activity.

Estimated Cancer Risk in Females Who Meet the Criteria to Exit Cervical Cancer Screening.

Importance: Cervical screening guidelines in the US recommend that most females can exit routine screening at age 65 years following 2 recent consecutive negative cotest results (concurrent human papillomavirus and cytology tests). However, empirical data on the subsequent risks of cancer and cancer death in this subgroup of females are limited.

Objective: To estimate the risks of cervical cancer and cervical cancer death among females who meet the cotesting criteria to exit screening.

Iridium Nanocrystals Enriched with Defects and Atomic Steps to Enhance Oxygen Evolution Reaction Performance.

The presence of defects can significantly improve catalytic activity and stability, as they influence the binding of the reactants, intermediates, and products to the catalyst. Controlling defects in the structures of nanocrystal catalysts is synthetically challenging. In this study, we demonstrate the ability to control the growth of Ir nanocrystals, enabling the tuning of both structural and surface defects.