Academic Drug Discovery Units in the UK: Progress and challenges.

The contributions of academic drug discovery are well characterised in the US context but less well understood elsewhere. This paper provides a UK perspective, focusing on the activities of Drug Discovery Units (DDUs). These units have established themselves as coordinators of translational research, working at the early stages of the drug pipeline to link up the academic and industry capabilities needed to take drug candidates towards the market.

Demographics shape public preferences for carbon dioxide removal and solar geoengineering interventions across 30 countries.

Climate intervention technologies such as carbon dioxide removal and solar geoengineering are becoming more actively considered as solutions to global warming. The demographic aspects of the public serve as a core determinant of social vulnerability and the ability for people to cope with, or fail to cope with, exposure to heat waves, air pollution, or disruptions in access to modern energy services. This study examines public preferences for 10 different climate interventions utilizing an original, large-scale, cross-country set of nationally representative surveys in 30 countries.

A joint research agenda for climate action bridges behavioral sciences and urban planning.

We argue for systematically integrating behavioral sciences and urban planning to develop a joint agenda for research and planning practice. By viewing urban form as a critical choice architecture for making people’s choices more climate-friendly, this approach may unlock new pathways for higher liveability of cities.

Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations: a comparison of England and Denmark using the OpenSAFELY platform and National Registry Data.

Objectives: To examine the impact of the COVID-19 pandemic on deprivation-related inequalities in hospitalisations for cardiovascular disease (CVD) conditions in Denmark and England between March 2018 and December 2021.

Design: Time-series studies in England and Denmark.

Setting: With the approval of National Health Service England, we used English primary care electronic health records, linked to secondary care and death registry data through the OpenSAFELY platform and nationwide Danish health registry data.

The low-carbon risk society: Dilemmas of risk-risk tradeoffs in energy innovations, transitions, and climate policy.

As countries and communities grapple with climate change, they seek to rapidly decarbonize their economies and cultures. A low-carbon future will likely depend on more distributed solar energy, the electrification of mobility, and more efficient homes and buildings. But what emergent risks are evident within this low-carbon society? This exploratory study first reviews the existing literature to identify 75 risk-risk tradeoffs by their category, medium of distribution, and type.

Like diamonds in the sky? Public perceptions, governance, and information framing of solar geoengineering activities in Mexico, the United Kingdom, and the United States.

Solar geoengineering (also known as solar radiation modification) is garnering more attention (and controversy) among media and policymakers in response to the impacts of climate change. Such debates have become more prominent following the first-ever field trials of stratospheric aerosol injection (SAI) in 2022. How the lay public perceives solar geoengineering remains unclear, however.

Screen time, mute, mixed messages, and panic: An international auto-ethnographic study of knowledge workers during a pandemic.

The coronavirus pandemic provoked worldwide changes to the workplace, leading to rapid changes in lifestyles and working conditions. While organizations and governments struggled to develop regulations and policies, individuals were forced to find ways to manage work and life. During the pandemic and quarantine, a group of knowledge workers from around the world convened virtually and agreed to use qualitative autoethnographic methods to study how the quarantine disrupted their conventional patterns of work and care.

Public engagement for inclusive and sustainable governance of climate interventions.

The need for public engagement is increasingly evident as discussions intensify around emerging methods for carbon dioxide removal and controversial proposals around solar geoengineering. Based on 44 focus groups in 22 countries across the Global North and Global South (N = 323 participants), this article traces public preferences for a variety of bottom-up and top-down engagement practices ranging from information recipient to broad decision authority. Here, we show that engagement practices need to be responsive to local political cultures and socio-technical environments, while attending to the global dimensions and interconnectedness of the issues at stake.

How students learn to lead in pre- and early-career experiences.

This study illuminates the leadership experiences of undergraduate business students undertaking a 1-year work placement. Semi-structured interviews and reflective journals were used to explore the students' leadership experiences before and during their placement. Through reflection on these experiences, students were able to make sense of their own leadership learning as well as develop their leadership identity.

Inherent Bias in Electronic Health Records: A Scoping Review of Sources of Bias.

Objectives: 1.1Biases inherent in electronic health records (EHRs), and therefore in medical artificial intelligence (AI) models may significantly exacerbate health inequities and challenge the adoption of ethical and responsible AI in healthcare. Biases arise from multiple sources, some of which are not as documented in the literature.

Public perceptions on carbon removal from focus groups in 22 countries.

Carbon removal is emerging as a pillar of governmental and industry commitments toward achieving Net Zero targets. Drawing from 44 focus groups in 22 countries, we map technical and societal issues that a representative sample of publics raise on five major types of carbon removal (forests, soils, direct air capture, enhanced weathering, and bioenergy with carbon capture and storage), and how these translate to preferences for governance actors, mechanisms, and rationales. We assess gaps and overlaps between a global range of public perceptions and how carbon removal is currently emerging in assessment, innovation, and decision-making.

Public perceptions and support of climate intervention technologies across the Global North and Global South.

Novel, potentially radical climate intervention technologies like carbon dioxide removal and solar geoengineering are attracting attention as the adverse impacts of climate change are increasingly felt. The ability of publics, particularly in the Global South, to participate in discussions about research, policy, and deployment is restricted amidst a lack of familiarity and engagement. Drawing on a large-scale, cross-country exercise of nationally representative surveys (N = 30,284) in 30 countries and 19 languages, this article establishes the first global baseline of public perceptions of climate-intervention technologies.

Actors, legitimacy, and governance challenges facing negative emissions and solar geoengineering technologies.

Institutional theory, behavioral science, sociology and even political science all emphasize the importance of actors in achieving social change. Despite this salience, the actors involved in researching, promoting, or deploying negative emissions and solar geoengineering technologies remain underexplored within the literature. In this study, based on a rigorous sample of semi-structured expert interviews ( = 125), we empirically explore the types of actors and groups associated with both negative emissions and solar geoengineering research and deployment.

Virtual reality technology for surgical learning: qualitative outcomes of the first virtual reality training course for emergency and essential surgery delivered by a UK-Uganda partnership.

Introduction: The extensive resources needed to train surgeons and maintain skill levels in low-income and middle-income countries (LMICs) are limited and confined to urban settings. Surgical education of remote/rural doctors is, therefore, paramount. Virtual reality (VR) has the potential to disseminate surgical knowledge and skill development at low costs.

Attention, sentiments and emotions towards emerging climate technologies on Twitter.

Public perception of emerging climate technologies, such as greenhouse gas removal (GGR) and solar radiation management (SRM), will strongly influence their future development and deployment. Studying perceptions of these technologies with traditional survey methods is challenging, because they are largely unknown to the public. Social media data provides a complementary line of evidence by allowing for retrospective analysis of how individuals share their unsolicited opinions.

Transforming the grid for a more environmentally and socially sustainable electricity system in Great Britain is a slow and uneven process.

Electricity system decarbonization is key for environmental sustainability. From a consumption-production perspective, much attention has been paid to changes in how electricity is generated and used, but electricity systems also rely on a grid infrastructure that connects and integrates production and consumption, and which will also need to transform. At the same time, new technologies in the electricity system, including the grid, offer the potential for more socially sustainable ways of producing and consuming energy.

Participation through the lens of care: Situated accountabilities in the codesign of a digital health platform for HIV care.

Participation of citizens and service users is increasingly commonplace in research, policy and technology development. Alongside this development, social scientists have become increasingly incorporated into large-scale research and innovation projects to facilitate participatory spaces. This requires reflection on the mechanisms, outcomes and, ultimately, the accountabilities of participation.

Online information search by people with Multiple Sclerosis: A systematic review.

Background: People with Multiple Sclerosis (pwMS) search for information online about various aspects of living with their disease, but details about patterns of searching and outcomes are unclear. This means that opportunities to leverage online resources to support pwMS, and to enhance shared decision making, may be missed. We aimed to do a systematic review of the literature on digital information searching by pwMS.

The political economy of net-zero transitions: Policy drivers, barriers, and justice benefits to decarbonization in eight carbon-neutral countries.

This study examines the political economy of decarbonization in eight countries over the period 2000 to 2021/2022 that have already achieved a national net-zero transition. These countries are Bhutan, Suriname, Panama, Guyana, Comoros, Gabon, Madagascar, and Niue. It utilizes an analytical method of a rich, interdisciplinary and systematized literature review integrated with thematic analysis.

Living alone and mental health: parallel analyses in UK longitudinal population surveys and electronic health records prior to and during the COVID-19 pandemic.

Background: People who live alone experience greater levels of mental illness; however, it is unclear whether the COVID-19 pandemic had a disproportionately negative impact on this demographic.

Objective: To describe the mental health gap between those who live alone and with others in the UK prior to and during the COVID-19 pandemic.

Methods: Self-reported psychological distress and life satisfaction in 10 prospective longitudinal population surveys (LPSs) assessed in the nearest pre-pandemic sweep and three periods during the pandemic.

Ethnic differences in the indirect effects of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England: a population-based, observational cohort study using the OpenSAFELY platform.

Background: The COVID-19 pandemic disrupted healthcare and may have impacted ethnic inequalities in healthcare. We aimed to describe the impact of pandemic-related disruption on ethnic differences in clinical monitoring and hospital admissions for non-COVID conditions in England.

Methods: In this population-based, observational cohort study we used primary care electronic health record data with linkage to hospital episode statistics data and mortality data within OpenSAFELY, a data analytics platform created, with approval of NHS England, to address urgent COVID-19 research questions.

Governmentality Versus Community: The Impact of the COVID Lockdowns.

The COVID lockdowns were characterised by new forms of governmentality as lives were disrupted and controlled through the vertical transmission of biopolitics by the state. The paper considers how this was experienced by academics in 11 different countries through analysis of diaries written during the first lockdown. The paper asks if communities can offer an alternative to governmentality by looking at three levels: the national, the neighbourhood and the personal.

Use of delivery drones for humanitarian operations: analysis of adoption barriers among logistics service providers from the technology acceptance model perspective.

Delivery drones are yet to be adopted as a systematic delivery system for humanitarian operations but have the potential to substantially increase the efficiency and effectiveness of future delivery options. Thus, we analyse the impact of factors affecting the adoption of delivery drones by logistics service providers for humanitarian operations. A conceptual model of potential barriers to adoption and development is created using the Technology Acceptance Model theory involving security, perceived usefulness, perceived ease of use and attitude as factors that affect the intention to use.

Overconfidence at the time of COVID-19:Does it lead to laxer attitudes?

Background: Health education campaigns often aim to create awareness by increasing objective knowledge about pathogens, such as COVID-19. However, the present paper proposes that confidence in one's knowledge more than knowledge is a significant factor that leads to a laxer attitude toward COVID-19 and hence lower support for protective measures and reduced intention to comply with preemptive behaviors.

Methods: We tested two hypotheses in three studies conducted between 2020 and 2022.