Unusual pseudocapacitive lithium-ion storage on defective CoOnanosheets.

Secondary lithium-ion batteries are restricted in large-scale applications including power grids and long driving electric vehicles owing to the low specific capacity of conventional intercalation anodes possessing sluggish Li-ion diffusion kinetics. Herein, we demonstrate an unusual pseudocapacitive lithium-ion storage on defective CoOnanosheet anodes for high-performance rechargeable batteries. Cobalt-oxide nanosheets presented here composed of various defects including vacancies, dislocations and grain boundaries.

Hypervalent iodine promoted the synthesis of cycloheptatrienes and cyclopropanes.

A new strategy is reported for intramolecular Buchner-type reactions using PIDA as a promotor. Traditionally, the Buchner reaction is achieved Rh-carbenoids derived from Rh catalysts with diazo compounds. Herein, the first metal-free Buchner-type reaction to construct highly strained cycloheptatriene- and cyclopropane-fused lactams is presented.

Understanding the emotional response to COVID-19 information in news and social media: A mental health perspective.

The impact of the COVID-19 pandemic and ensuing social restrictions has been profound, affecting the health, livelihoods, and wellbeing of populations worldwide. Studies have shown widespread effects on mental health, with an increase in stress, loneliness, and depression symptoms related to the pandemic. Media plays a critical role in containing and managing crises, by informing society and fostering positive behavior change.

Followers' unclear demands during the COVID-19 pandemic can undermine leaders' well-being: A moderated mediation model from an entrapment perspective.

Although effective leaders are important for reducing employee stress during the COVID-19, limited studies have examined how follower behaviors can influence leader stress and well-being during the COVID-19. This study draws on defeat-entrapment theory to examine how followers' unclear demands during the COVID-19 consequently impact leaders' psychological states and well-being. We conducted a three-wave time-lagged investigation with a sample of 281 leaders in the United Kingdom and found that followers' unclear demands could generate feelings of entrapment in leaders, leading to decreased levels of well-being outcomes in leaders.

Predictive scores for identifying patients with type 2 diabetes mellitus at risk of acute myocardial infarction and sudden cardiac death.

Introduction: The present study evaluated the application of incorporating non-linear J/U-shaped relationships between mean HbA1c and cholesterol levels into risk scores for predicting acute myocardial infarction (AMI) and non-AMI-related sudden cardiac death (SCD) respectively, amongst patients with type 2 diabetes mellitus.

Methods: This was a territory-wide cohort study of patients with type 2 diabetes mellitus above the age 40 and free from prior AMI and SCD, with or without prescriptions of anti-diabetic agents between January 1st, 2009 to December 31st, 2009 at government-funded hospitals and clinics in Hong Kong. Patients recruited were followed up until 31 December 2019 or their date of death.

Development and validation of early warning score systems for COVID-19 patients.

COVID-19 is a major, urgent, and ongoing threat to global health. Globally more than 24 million have been infected and the disease has claimed more than a million lives as of November 2020. Predicting which patients will need respiratory support is important to guiding individual patient treatment and also to ensuring sufficient resources are available.

Single-atom catalysts for high-energy rechargeable batteries.

Clean and sustainable electrochemical energy storage has attracted extensive attention. It remains a great challenge to achieve next-generation rechargeable battery systems with high energy density, good rate capability, excellent cycling stability, efficient active material utilization, and high coulombic efficiency. Many catalysts have been explored to promote electrochemical reactions during the charge and discharge process.

Realization of High Energy Density Sodium-Ion Hybrid Capacitors through Interface Engineering of Pseudocapacitive 3D-CoO-NrGO Hybrid Anodes.

Sodium-ion hybrid capacitors (SHCs) have attracted great attention owing to the improved power density and cycling stability in comparison with sodium-ion batteries. Nevertheless, the energy density (<100 Wh·kg) is usually limited by low specific capacity anodes (<150 mAh·g) and "kinetics mismatch" between the electrodes. Hence, we report a high energy density (153 Wh·kg) SHC based on a highly pseudocapacitive interface-engineered 3D-CoO-NrGO anode.

Modular Construction of Prussian Blue Analog and TiO Dual-Compartment Janus Nanoreactor for Efficient Photocatalytic Water Splitting.

Janus structures that include different functional compartments have attracted significant attention due to their specific properties in a diverse range of applications. However, it remains challenge to develop an effective strategy for achieving strong interfacial interaction. Herein, a Janus nanoreactor consisting of TiO 2D nanocrystals integrated with Prussian blue analog (PBA) single crystals is proposed and synthesized by mimicking the planting process.

Resistant Starch Production and Glucose Release from Pre-Prepared Chilled Food: The SPUD Project.

With an increasing prevalence of diabetes worldwide, effective dietary strategies for blood glucose control are crucial. As carbohydrates make up approximately 50% of the diet, it is neither practical nor advisable to avoid them altogether. Most of the carbohydrate in the diet is derived from starch, found in potatoes, pasta, rice and bread.

Loosen control without losing control: Formalization and decentralization within commons-based peer production.

This study considers commons-based peer production (CBPP) by examining the organizational processes of the free/libre open-source software community, Drupal. It does so by exploring the sociotechnical systems that have emerged around both Drupal's development and its face-to-face communitarian events. There has been criticism of the simplistic nature of previous research into free software; this study addresses this by linking studies of CBPP with a qualitative study of Drupal's organizational processes.

Continuous selective deoxygenation of palm oil for renewable diesel production over Ni catalysts supported on AlO and LaO-AlO.

The present study provides, for the first time in the literature, a comparative assessment of the catalytic performance of Ni catalysts supported on γ-AlO and γ-AlO modified with LaO, in a continuous flow trickle bed reactor, for the selective deoxygenation of palm oil. The catalysts were prepared the wet impregnation method and were characterized, after calcination and/or reduction, by N adsorption/desorption, XRD, NH-TPD, CO-TPD, H-TPR, H-TPD, XPS and TEM, and after the time-on-stream tests, by TGA, TPO, Raman and TEM. Catalytic experiments were performed between 300-400 °C, at a constant pressure (30 bar) and different LHSV (1.

APOBEC and Cancer Viroimmunotherapy: Thinking the Unthinkable.

The apolipoprotein B mRNA editing enzyme catalytic polypeptide (APOBEC) family protects against infection by degrading incoming viral genomes through cytosine deamination. Here, we review how the potential to unleash these potent DNA mutagens comes at a price as APOBEC DNA mutagenesis can contribute to development of multiple types of cancer. In addition, because viral infection induces its expression, APOBEC is seen as the enemy of oncolytic virotherapy through mutation of the viral genome and by generating virotherapy-resistant tumors.

The alkali degradation of LDPE-based radiation-grafted anion-exchange membranes studied using different e methods.

Radiation-grafted anion-exchange membranes (RG-AEM) in alkaline membrane fuel cells (AEMFC) exhibit promising performances (low resistances, high power outputs and reasonably high alkali stabilities). Much research is focused on developing AEMs with enhanced chemical stabilities in the OH-forms at temperatures >60 °C. This study contributes towards this effort by providing a comparison of three different methods of screening alkali stabilities (where different laboratories conducted experiments on exactly the same batches of RG-AEM).

Electrochemical performance of nano-sized LiFePO-embedded 3D-cubic ordered mesoporous carbon and nitrogenous carbon composites.

Herein, we report a single-step synthesis, characterization, and electrochemical performance of nano-sized LiFePO (LFP)-embedded 3D-cubic mesoporous carbon (CSI-809) and nitrogenous carbon (MNC-859) composites. Furthermore, in order to investigate the effects of both CSI-809 and MNC-859 on the electrochemical characteristics of LFP, a systematic study was performed on the morphology and microstructure of the composites, , LFP/CSI-809 and LFP/MNC-859, using XRD, FE-SEM, FT-Raman, and BET surface area analyses. Among these composites, LFP/MNC-859 exhibited better electrochemical performance with higher specific capacity and rate capability as compared to those of LFP/CSI-809.

Mechanochromic and Thermochromic Sensors Based on Graphene Infused Polymer Opals.

High quality opal-like photonic crystals containing graphene are fabricated using evaporation-driven self-assembly of soft polymer colloids. A miniscule amount of pristine graphene within a colloidal crystal lattice results in the formation of colloidal crystals with a strong angle-dependent structural color and a stop band that can be reversibly shifted across the visible spectrum. The crystals can be mechanically deformed or can reversibly change color as a function of their temperature, hence their sensitive mechanochromic and thermochromic response make them attractive candidates for a wide range of visual sensing applications.

Regression of Atherosclerosis in ApoE-/- Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel "Cytotopic" Anti-Thrombin Without Prolonged Anticoagulation.

Background Anticoagulants induce atherosclerosis regression in animal models but exploiting this clinically is limited by bleeding events. Here we test a novel thrombin inhibitor, PTL060, comprising hirulog covalently linked to a synthetic myristoyl electrostatic switch to tether to cell membranes. Methods and Results ApoE-/- mice were fed chow or high-fat diets, before transplantation of congenic aortic segments or injection of PTL060, parental hirulog, control saline, or labeled CD11b positive cells.

Janus particles: design, preparation, and biomedical applications.

Janus particles with an anisotropic structure have emerged as a focus of intensive research due to their diverse composition and surface chemistry, which show excellent performance in various fields, especially in biomedical applications. In this review, we briefly introduce the structures, composition, and properties of Janus particles, followed by a summary of their biomedical applications. Then we review several design strategies including morphology, particle size, composition, and surface modification, that will affect the performance of Janus particles.

Description of the Lesch-Nyhan neurobehavioral disorder and its management through participant observation of three young individuals.

Background: Lesch-Nyhan disease (LND; OMIM 300322), caused by virtually absent hypoxanthine-guanine phosphoribosyltransferase activity, in its classic form is characterised by hyperuricemia, variable cognitive impairment, severe motor disorder and a characteristic behavioural disorder (Lesch-Nyhan Behavior, LNB), typically described as self-injurious behavior (SIB) and "self-mutilation." This work focuses on the latter aspect with the aim of exploring and broadening it.

Methods: The participant observation method was used to follow three children diagnosed with LND individually, in different contexts of daily life, always with their usual restraints and in the presence of a caregiver.

Impaired platelet-dependent thrombin generation associated with thrombocytopenia is improved by prothrombin complex concentrates in vitro.

Background: Impaired thrombin generation (TG) in patients with acquired coagulopathy, is due to low coagulation factors and thrombocytopenia. The latter is typically treated with platelet transfusions and the former with plasma and occasionally with prothrombin complex concentrates (PCCs). We hypothesized that manipulating the concentrations of coagulation factors might result in restoration of platelet-dependent TG over and above that of simple replacement therapy.

A selective and easily recyclable dimer based on a calix[4]pyrrole derivative for the removal of mercury(ii) from water.

A recyclable mercury(ii) selective dimer based on a calix[4]pyrrole derivative has been synthesised and characterised by mass and FT-IR spectrometry, Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray (EDX). Information regarding the ability of the dimer to interact with metal cations was obtained from FTIR and SEM-EDX analyses. A striking feature of micrographs of the loaded dimer is the change of morphology with the cation.

Chemoradiotherapy screening in a novel biomimetic polymer based pancreatic cancer model.

Pancreatic Ductal Adenocarcinoma (PDAC) is a deadly and aggressive disease with a very low survival rate. This is partly due to the resistance of the disease to currently available treatment options. Herein, we report for the first time the use of a novel polyurethane scaffold based PDAC model for screening the short and relatively long term (1 and 17 days post-treatment) responses of chemotherapy, radiotherapy and their combination.

End of season influenza vaccine effectiveness in primary care in adults and children in the United Kingdom in 2018/19.

2018/19 was the first season of introduction of a newly licensed adjuvanted influenza vaccine (aTIV) for adults aged 65 years and over and the sixth season in the roll-out of a childhood influenza vaccination programme with a quadrivalent live attenuated influenza vaccine (LAIV). The season saw mainly A(H1N1)pdm09 and latterly A(H3N2) circulation. End-of-season adjusted vaccine effectiveness (aVE) estimates against laboratory confirmed influenza infection in primary care were calculated using the test negative case control method adjusting for key confounders.

Appraisal of Cu(ii) adsorption by graphene oxide and its modelling artificial neural network.

Graphene oxide (GO), as an emerging material, exhibits extraordinary performance in terms of water treatment. Adsorption is a process that is influenced by multiple factors and is difficult to simulate by traditional statistical models. Artificial neural networks (ANNs) can establish highly accurate nonlinear functional relationships between multiple variables; hence, we constructed a three-layered ANN model to predict the removal performance of Cu(ii) metal ions by the prepared GO.