Temperature-Dependent Nitrous Oxide/Carbon Dioxide Preferential Adsorption in a Thiazolium-Functionalized NU-1000 Metal-Organic Framework.

Solvent-assisted ligand incorporation (SALI) of the ditopic linker 5-carboxy-3-(4-carboxybenzyl)thiazolium bromide [()Br] into the zirconium metal-organic framework [ZrO(OH)(HO)(TBAPy), where NU = Northwestern University and HTBAPy = 1,3,6,8-tetrakis(-benzoic-acid)pyrene], led to the SALIed material of minimal formula [ZrO(OH)(HO)(TBAPy)()]Br. has been thoroughly characterized in the solid state. As confirmed by powder X-ray diffraction, this material keeps the same three-dimensional architecture of and the dicarboxylic extra linker bridges adjacent [Zr] nodes 8 Å far apart along the crystallographic -axis.

Eruption of Bioengineered Teeth: A New Approach Based on a Polycaprolactone Biomembrane.

Obtaining a functional tooth is the ultimate goal of tooth engineering. However, the implantation of bioengineered teeth in the jawbone of adult animals never allows for spontaneous eruption due mainly to ankylosis within the bone crypt. The objective of this study was to develop an innovative approach allowing eruption of implanted bioengineered teeth through the isolation of the germ from the bone crypt using a polycaprolactone membrane (PCL).

Carbon Dioxide Capture and Utilization with Isomeric Forms of Bis(amino)-Tagged Zinc Bipyrazolate Metal-Organic Frameworks.

Aiming at extending the tagged zinc bipyrazolate metal-organic frameworks (MOFs) family, the ligand 3,3'-diamino-4,4'-bipyrazole (3,3'-H L) has been synthesized in good yield. The reaction with zinc(II) acetate hydrate led to the related MOF Zn(3,3'-L). The compound is isostructural with its mono(amino) analogue Zn(BPZNH ) and with Zn(3,5-L), its isomeric parent built with 3,5-diamino-4,4'-bipyrazole.

Highly Nickel-Loaded γ-Alumina Composites for a Radiofrequency-Heated, Low-Temperature CO Methanation Scheme.

In this work, we joined highly Ni-loaded γ-Al O composites, straightforwardly prepared by impregnation methods, with an induction heating setup suited to control, almost in real-time, any temperature swing at the catalyst sites (i. e., "hot spots" ignition) caused by an exothermic reaction at the heart of the power-to-gas (P2G) chain: CO methanation.

Cobalt(II) Bipyrazolate Metal-Organic Frameworks as Heterogeneous Catalysts in Cumene Aerobic Oxidation: A Tag-Dependent Selectivity.

Three metal-organic frameworks with the general formula (BPZX = 3-X-4,4'-bipyrazolate, X = H, NH, NO) constructed with ligands having different functional groups on the same skeleton have been employed as heterogeneous catalysts for aerobic liquid-phase oxidation of cumene with O as oxidant. O adsorption isotherms collected at = 1 atm and = 195 and 273 K have cast light on the relative affinity of these catalysts for dioxygen. The highest gas uptake at 195 K is found for (3.

Playing with covalent triazine framework tiles for improved CO adsorption properties and catalytic performance.

The rational design and synthesis of covalent triazine frameworks (CTFs) from defined dicyano-aryl building blocks or their binary mixtures is of fundamental importance for a judicious tuning of the chemico-physical and morphological properties of this class of porous organic polymers. In fact, their gas adsorption capacity and their performance in a variety of catalytic transformations can be modulated through an appropriate selection of the building blocks. In this contribution, a set of five CTFs (-) have been prepared under classical ionothermal conditions from single dicyano-aryl or heteroaryl systems.

Tuning Carbon Dioxide Adsorption Affinity of Zinc(II) MOFs by Mixing Bis(pyrazolate) Ligands with N-Containing Tags.

The four zinc(II) mixed-ligand metal-organic frameworks (MIXMOFs) Zn(BPZ)(BPZNO), Zn(BPZ)(BPZNH), Zn(BPZNO)(BPZNH), and Zn(BPZ)(BPZNO)(BPZNH) (HBPZ = 4,4'-bipyrazole; HBPZNO = 3-nitro-4,4'-bipyrazole; HBPZNH = 3-amino-4,4'-bipyrazole) were prepared through solvothermal routes and fully investigated in the solid state. Isoreticular to the end members Zn(BPZ) and Zn(BPZX) (X = NO, NH), they are the first examples ever reported of (pyr)azolate MIXMOFs. Their crystal structure is characterized by a three-dimensional open framework with one-dimensional square or rhombic channels decorated by the functional groups.

Quick mass-production of MAX (TiAlC) book with pages separated by stacking faults benefiting removal of "A" layer.

A creative and universal technique, magnetism and vortex current coupling growth (MVC), has been developed for the super-rapid mass-production of the layered MAX (TiAlC) phase. The book-like MAX grows from the bottom to the top layer by layer, separated by stacking faults to benefit the removal of the "A" layer from MAX.

Hydrogenolysis of Dinuclear PCN Ligated Pd μ-Hydroxides and Their Mononuclear Pd Hydroxide Analogues.

The hydrogenolysis of mono- and dinuclear Pd hydroxides was investigated both experimentally and computationally. It was found that the dinuclear μ-hydroxide complexes {[(PCN )Pd] (μ-OH)}(OTf) (PCN =1-[3-[(di-tert-butylphosphino)methyl]phenyl]-1H-pyrazole; PCN =1-[3-[(di-tert-butylphosphino)methyl]phenyl]-5-methyl-1H-pyrazole) react with H to form the analogous dinuclear hydride species {[(PCN )Pd] (μ-H)}(OTf). The dinuclear μ-hydride complexes were fully characterized, and are rare examples of structurally characterized unsupported singly bridged μ-H Pd dimers.

Focus on the Different Projects of Telemedicine Centered on the Elderly In France.

Telemedicine is now in vogue, allowing computer and communication tools to be deployed in different fields of health, such as Cardiology, Dermatology, areas in which it has received interest, and in international studies. As the population ages, older people are increasingly concerned about this innovative practice. This is a narrative review of both the literature and Internet pertaining to telemedicine projects within the field of geriatric subjects in France.

Nickel Sulfides Decorated SiC Foam for the Low Temperature Conversion of H₂S into Elemental Sulfur.

The selective oxidation of H₂S to elemental sulfur was carried out on a NiS₂/SiC catalyst under reaction temperatures between 40 and 80 °C using highly H₂S enriched effluents (from 0.5 to 1 vol.%).

Periodontal Tissues, Maxillary Jaw Bone, and Tooth Regeneration Approaches: From Animal Models Analyses to Clinical Applications.

This review encompasses different pre-clinical bioengineering approaches for periodontal tissues, maxillary jaw bone, and the entire tooth. Moreover, it sheds light on their potential clinical therapeutic applications in the field of regenerative medicine. Herein, the electrospinning method for the synthesis of polycaprolactone (PCL) membranes, that are capable of mimicking the extracellular matrix (ECM), has been described.

Contamination of dental unit waterlines: assessment of three continuous water disinfection systems.

Objectives: To assess the efficacy of three continuous water disinfection systems for dental units under real conditions of dental care.

Design And Settings: A prospective study carried out from 45 days to 20 months on the water microbial quality of the dental units is benefited from three different systems: two chemical treatment systems (IGN EVO/Calbenium/IGN Cartridge and Sterispray) and one physical treatment system (BacTerminator). Studied items were six dental units of the Dental Medicine and Oral Surgery Center within the University Hospital of Strasbourg (HUS), France.

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis.

The mechanisms underlying transthyretin-related amyloidosis in vivo remain unclear. The abundance of the 49-127 transthyretin fragment in ex vivo deposits suggests that a proteolytic cleavage has a crucial role in destabilizing the tetramer and releasing the highly amyloidogenic 49-127 truncated protomer. Here, we investigate the mechanism of cleavage and release of the 49-127 fragment from the prototypic S52P variant, and we show that the proteolysis/fibrillogenesis pathway is common to several amyloidogenic variants of transthyretin and requires the action of biomechanical forces provided by the shear stress of physiological fluid flow.

Microfluidic conceived Trojan microcarriers for oral delivery of nanoparticles.

In this study, we report on a novel method for the synthesis of poly(acrylamide) Trojan microparticles containing ketoprofen loaded poly(ethyl acrylate) or poly(methyl acrylate) nanoparticles. To develop these composite particles, a polymerizable nanoemulsion was used as a template. This nanoemulsion was obtained in an elongational-flow micromixer (μRMX) which was linked to a capillary-based microfluidic device for its emulsification into micron range droplets.

A Novel Mutation in the ROGDI Gene in a Patient with Kohlschütter-Tönz Syndrome.

Kohlschütter-Tönz Syndrome (KTZS) is an autosomal recessive disorder caused by mutations in the ROGDI gene. This syndrome is characterized by epilepsy, psychomotor regression and amelogenesis imperfecta. In this paper, we report a case of a 13-year-old Malian girl presenting with this rare disease.

Silicon carbide coated with TiO2 with enhanced cobalt active phase dispersion for Fischer-Tropsch synthesis.

The introduction of a thin layer of TiO2 on β-SiC allows a significant improvement of the cobalt dispersion. This catalyst exhibits an excellent and stable catalytic activity for the Fischer-Tropsch synthesis (FTS) with high C5+ selectivity, which contributes to the development of a new active catalyst family in the gas-to-liquid process.

Microfluidic conceived pH sensitive core-shell particles for dual drug delivery.

In current study, we report on the synthesis of core-shell microparticles for dual drug delivery by means of a two co-axial microfluidic device and online UV assisted free radical polymerization. Before developing pH-sensitive particles, ketoprofen loaded poly(methyl acrylate) core-ranitidine HCl loaded poly(acrylamide) shell particles were produced. Influence of inner and outer phases flow rates on particle size, shape, core diameter, shell thickness, and drug release properties was studied.

Microfluidic conceived drug loaded Janus particles in side-by-side capillaries device.

A side-by-side capillaries microfluidic device was developed to fabricate drug loaded poly(acrylamide)/poly(methyl acrylate) Janus particles in the range of 59-240 μm by UV-assisted free radical polymerization. This system was characterized in terms of continuous and dispersed phases flow rates (Qc/Qd), monomer composition of the two compartments, surfactant nature and concentration, outlet tube diameter and UV intensity. These factors were adequately controlled to get different particle shapes ranging from core-shell to bi-compartmental particles.

FOXL2 is a female sex-determining gene in the goat.

The origin of sex reversal in XX goats homozygous for the polled intersex syndrome (PIS) mutation was unclear because of the complexity of the mutation that affects the transcription of both FOXL2 and several long noncoding RNAs (lncRNAs). Accumulating evidence suggested that FOXL2 could be the sole gene of the PIS locus responsible for XX sex reversal, the lncRNAs being involved in transcriptional regulation of FOXL2. In this study, using zinc-finger nuclease-directed mutagenesis, we generated several fetuses, of which one XX individual bears biallelic mutations of FOXL2.

Microfluidics: a focus on improved cancer targeted drug delivery systems.

Pharmaceutical science aims to localize the pharmacological activity of the drug at the site of action. Targeted drug delivery systems can directly deliver the payload to the desired site of action without undesired interaction with normal cells. This is especially important for anticancer drugs to avoid side effects and improve therapeutic response and patient compliance.

Light-triggered self-construction of supramolecular organic nanowires as metallic interconnects.

The construction of soft and processable organic material able to display metallic conduction properties-a large density of freely moving charges-is a major challenge for electronics. Films of doped conjugated polymers are widely used as semiconductor devices, but metallic-type transport in the bulk of such materials remains extremely rare. On the other hand, single-walled carbon nanotubes can exhibit remarkably low contact resistances with related large currents, but are intrinsically very difficult to isolate and process.