Who cares about lab rodents?

Humanities and social sciences help advance "cultures of care" around laboratory animal science and welfare.

The Brazilian COVID-19 vaccination campaign: a modelling analysis of sociodemographic factors on uptake.

Objective: Dose shortages delayed access to COVID-19 vaccination. We aim to characterise inequality in two-dose vaccination by sociodemographic group across Brazil.

Design: This is a cross-sectional study.

Correction: Constructing collective identities and solidarity in premiers' early speeches on COVID-19: a global perspective.

[This corrects the article DOI: 10.1057/s41599-021-00805-x.].

Radically open DBT: Targeting emotional loneliness in Anorexia Nervosa.

This article conceptualizes Anorexia Nervosa (AN) as a prototypical overcontrolled disorder, characterized by low receptivity and openness, low flexible control, pervasive inhibited emotional expressiveness, low emotional awareness, and low social connectedness and intimacy with others. As a result, individuals with AN often report high levels of emotional loneliness. A new evidence-based treatment, Radically Open Dialectical Behavior Therapy (RO-DBT), and its underlying neuroregulatory theory, offer a novel way of understanding how self-starvation and social signaling deficits are used as maladaptive regulation strategies to reduce negative affect.

Systematic evaluation of patient-reported outcome (PRO) protocol content and reporting in UK cancer clinical trials: the EPiC study protocol.

Introduction: Emerging evidence suggests that patient-reported outcome (PRO)-specific information may be omitted in trial protocols and that PRO results are poorly reported, limiting the use of PRO data to inform cancer care. This study aims to evaluate the standards of PRO-specific content in UK cancer trial protocols and their arising publications and to highlight examples of best-practice PRO protocol content and reporting where they occur. The objective of this study is to determine if these early findings are generalisable to UK cancer trials, and if so, how best we can bring about future improvements in clinical trials methodology to enhance the way PROs are assessed, managed and reported.

The Restoration of Passive Rotational Tibio-Femoral Laxity after Anterior Cruciate Ligament Reconstruction.

While the anterior cruciate ligament (ACL) is considered one of the most important ligaments for providing knee joint stability, its influence on rotational laxity is not fully understood and its role in resisting rotation at different flexion angles in vivo remains unknown. In this prospective study, we investigated the relationship between in vivo passive axial rotational laxity and knee flexion angle, as well as how they were altered with ACL injury and reconstruction. A rotometer device was developed to assess knee joint rotational laxity under controlled passive testing.

Biomarker Profiles in Asthma With High vs Low Airway Reversibility and Poor Disease Control.

Background: High bronchodilator reversibility in adult asthma is associated with distinct clinical characteristics. This analysis compares lung function, biomarker profiles, and disease control in patients with high reversibility (HR) and low reversibility (LR) asthma.

Methods: A retrospective analysis was performed with data from two completed clinical trials of similar design.

Long-acting muscarinic antagonist use in adults with asthma: real-life prescribing and outcomes of add-on therapy with tiotropium bromide.

Background: Randomized controlled trials indicate that addition of a long-acting muscarinic antagonist (LAMA) such as tiotropium may improve asthma control and reduce exacerbation risk in patients with poorly controlled asthma, but broader clinical studies are needed to investigate the effectiveness of LAMA in real-life asthma care.

Methods: Medical records of adults with asthma (aged ≥18 years) prescribed tiotropium were obtained from the UK Optimum Patient Care Research Database for the period 2001-2013. Patients diagnosed with chronic obstructive pulmonary disease were excluded, but no other clinical exclusions were applied.

Reliability of a New Radiographic Classification for Developmental Dysplasia of the Hip.

Background: Existing radiographic classification schemes (eg, Tönnis criteria) for DDH quantify the severity of disease based on the position of the ossific nucleus relative to Hilgenreiner's and Perkin's lines. By definition, this method requires the presence of an ossification centre, which can be delayed in appearance and eccentric in location within the femoral head. A new radiographic classification system has been developed by the International Hip Dysplasia Institute (IHDI), which uses the mid-point of the proximal femoral metaphysis as a reference landmark, and can therefore be applied to children of all ages.

International scientific collaboration in HIV and HPV: a network analysis.

Research endeavours require the collaborative effort of an increasing number of individuals. International scientific collaborations are particularly important for HIV and HPV co-infection studies, since the burden of disease is rising in developing countries, but most experts and research funds are found in developed countries, where the prevalence of HIV is low. The objective of our study was to investigate patterns of international scientific collaboration in HIV and HPV research using social network analysis.

Dying with motor neurone disease, what can we learn from family caregivers?

Background: Increasingly, people with neurodegenerative illness are cared for at home until close to death. Yet, discussing the reality of dying remains a social taboo.

Objective: To examine the ways, family caregivers of people living with motor neurone disease (MND) experienced the dying of their relative and to identify how health practitioners can better prepare families for end-of-life care.

Sociodemographic and behavioural characteristics of youth reporting HIV testing in three Caribbean countries.

Objectives: Human Immunodeficiency Virus (HIV) testing is the gateway to treatment and care of HIV infection, however little is known about the HIV testing behaviours among Caribbean youth. The objective of this study was to determine the prevalence of HIV testing and to examine associations of HIV testing with sociodemographic characteristics and risk behaviours.

Methods: Data were used from nationally representative surveys in three Caribbean countries: Guyana AIDS Indicator Survey 2005-2006; Haiti Demographic and Health Survey 2005-2006 and the Dominican Republic Demographic and Health Survey 2007.

Mortality anxiety as a function of intrinsic religiosity and perceived purpose in life.

Fear of dying and death may be universal, but individuals differ in their emotional reactions to dying and death. The present study included a sample of 133 Chinese university students who were Christians. The authors tested a mediation model which posited that intrinsic religiosity, but not extrinsic religiosity, lowered anxiety toward the dying and death of self and someone close through fostering perceived purpose in life.

Promoting older people's voices- the contribution of social work to inter-disciplinary research.

UK government policies over the last decade or more have focussed on giving older people more voice in the design, delivery and assessment of services. Mirroring these trends, there has been a shift towards increased involvement of older people in the research process. Drawing on three research studies, this paper examines the contribution of social work to an inter-disciplinary research agenda designed to promote increased involvement of older people in issues of service quality in primarily health settings.

Synaesthesia: pitch-colour isomorphism in RGB-space?

A new experimental technique found coloured-hearing synaesthetes to possess localised isomorphism between pitch and colour. We found significantly more consistency in synaesthetes' pitch-colour matches than controls, with matches unaffected by musical experience, not facilitated by absolute pitch (AP) and responded to on the basis of pitch alone, without interference from note-name information. Synaesthetes also placed their colour responses to quartertones (notes falling between adjacent semitones) significantly closer to the RGB midpoint of their responses to the semitones lying either side.

Epidemiology of osteoporotic fracture: looking to the future.

This paper reviews the recent literature on candidate genes, anthropometric and environmental factors, and the evolving area of intrauterine fetal programming with regard to the development of osteoporosis.

Independent responses of Pacinian and Non-Pacinian systems with hand-transmitted vibration detected from masked thresholds.

This study was designed to identify psychophysical channels responsible for the detection of hand-transmitted vibration. Perception thresholds for vibration (16, 31.5, 63 and 125 Hz sinusoidal for 600 ms) at the distal phalanx of the middle finger and the whole hand were determined with and without simultaneous masking stimuli (1/3 octave bandwidth Gaussian random vibration centered on either 16 Hz or 125 Hz for 3000 ms, varying in magnitude 0 to 30 dB above threshold).

Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids.

The present study investigated whether consuming dairy products naturally enriched in cis-9, trans-11 (c9,t11) conjugated linoleic acid (CLA) by modification of cattle feed increases the concentration of this isomer in plasma and cellular lipids in healthy men. The study had a double-blind cross-over design. Subjects aged 34-60 years consumed dairy products available from food retailers for 1 week and then either control (0.